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Volume 13
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10.3390/jcm13237127
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Article

Whole Gut Motility Patterns in Patients with Chronic Nausea and Vomiting

by
Mette W. Klinge
1,
Anne Mette Haase
1,*,
Nanna Sutter Rolighed
1,
Klaus Krogh
1,
Mark Scott
2,
Vincent Schlageter
3,
Esben Bolvig Mark
4,
Gursharan Kaur Nandhra
5,
Asbjørn Mohr Drewes
4,6 and
Anders Bergh Loedrup
7
1
Department of Hepatology and Gastroenterology, Aarhus University Hospital, 8200 Aarhus N, Denmark
2
Blizard Institute, Queen Mary University of London, London E1 4NS, UK
3
Motilis Medica SA, 1007 Lausanne, Switzerland
4
Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, 9000 Aalborg, Denmark
5
Clinical Physics, Barts Health NHS Trust, The Royal London Hospital, London E1 1FR, UK
6
Department of Clinical Medicine, Aalborg University, 9220 Aalborg, Denmark
7
Department of Medicine, Section of Gastroenterology and Hepatology, Goedstrup Hospital, 7400 Herning, Denmark
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(23), 7127; https://doi.org/10.3390/jcm13237127
Submission received: 4 August 2024 / Revised: 2 September 2024 / Accepted: 20 November 2024 / Published: 25 November 2024
(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
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Abstract

Background/Objectives: Chronic nausea and vomiting (N/V) disorders are common in clinical practice. Our primary aim was to compare total and segmental gastrointestinal transit times as well as gastric contraction patterns in patients with chronic N/V syndrome to those of healthy volunteers (HVs). In the patient group, our secondary aim was to explore how symptoms and motility patterns were affected by a serotonin HT4 receptor agonist (Prucalopride). Methods: Patients with chronic N/V syndrome and HVs underwent baseline assessment of regional gastrointestinal (GI) motility/transit using the Motilis 3D-Transit system. Patients were then treated with Prucalopride 2 mg daily for 28 days, with the 3D-transit examination repeated within 10–20 days after treatment onset. Two self-administered questionnaires (the Gastrointestinal Symptom Rating Scale [GSRS] and Gastroparesis Cardinal Symptom Index [GCSI]) were used to assess patients’ symptoms. Results: A total of 19 patients (13 F; median age 25 years (IQR 22–39) and 55 HVs (25 F; median age 28 (24–35) were included. At baseline, no differences in regional GI transit times were found between groups. However, patients had a significantly lower gastric contraction amplitude than HVs (9 mmHg (IQR 8–11) vs. 12 (10–15: p < 0.001). In response to Prucalopride treatment, gastric emptying time was reduced from a median of 3.1 h to 1.6 h (p < 0.005). Further, the GCSI was significantly reduced from GCSI 3.0 (IQR 2.3–3.7) at baseline to GCSI 1.9 (IQR 1.3–3.2) with Prucalopride. Conclusions: Patients with chronic N/V syndrome have significantly lower gastric contraction amplitude than HVs and may symptomatically benefit from prokinetics. They do not, however, have evidence of panenteric dysmotility.
Keywords: gastrointestial motility; nausea; vomiting; transit times; dysmotility gastrointestial motility; nausea; vomiting; transit times; dysmotility

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MDPI and ACS Style

Klinge, M.W.; Haase, A.M.; Rolighed, N.S.; Krogh, K.; Scott, M.; Schlageter, V.; Mark, E.B.; Nandhra, G.K.; Drewes, A.M.; Loedrup, A.B. Whole Gut Motility Patterns in Patients with Chronic Nausea and Vomiting. J. Clin. Med. 2024, 13, 7127. https://doi.org/10.3390/jcm13237127

AMA Style

Klinge MW, Haase AM, Rolighed NS, Krogh K, Scott M, Schlageter V, Mark EB, Nandhra GK, Drewes AM, Loedrup AB. Whole Gut Motility Patterns in Patients with Chronic Nausea and Vomiting. Journal of Clinical Medicine. 2024; 13(23):7127. https://doi.org/10.3390/jcm13237127

Chicago/Turabian Style

Klinge, Mette W., Anne Mette Haase, Nanna Sutter Rolighed, Klaus Krogh, Mark Scott, Vincent Schlageter, Esben Bolvig Mark, Gursharan Kaur Nandhra, Asbjørn Mohr Drewes, and Anders Bergh Loedrup. 2024. "Whole Gut Motility Patterns in Patients with Chronic Nausea and Vomiting" Journal of Clinical Medicine 13, no. 23: 7127. https://doi.org/10.3390/jcm13237127

APA Style

Klinge, M. W., Haase, A. M., Rolighed, N. S., Krogh, K., Scott, M., Schlageter, V., Mark, E. B., Nandhra, G. K., Drewes, A. M., & Loedrup, A. B. (2024). Whole Gut Motility Patterns in Patients with Chronic Nausea and Vomiting. Journal of Clinical Medicine, 13(23), 7127. https://doi.org/10.3390/jcm13237127

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