Tumour-Induced Osteomalacia—A Long Way to the Diagnosis Facilitated by [68Ga]Ga-DOTATATE PET/CT

Kunikowska, Jolanta; Andryszak, Natalia; Skowrońska-Jóźwiak, Elżbieta; Pełka, Kacper; Zygmunt, Arkadiusz; Lewiński, Andrzej; Ruchała, Marek; Czepczyński, Rafał

doi:10.3390/jcm13061817

Open AccessFeature PaperArticle

Tumour-Induced Osteomalacia—A Long Way to the Diagnosis Facilitated by [⁶⁸Ga]Ga-DOTATATE PET/CT

by

Jolanta Kunikowska

^1,†

,

Natalia Andryszak

^2,*,†

,

Elżbieta Skowrońska-Jóźwiak

^3,4

,

Kacper Pełka

^1,5

,

Arkadiusz Zygmunt

^3,4

,

Andrzej Lewiński

^3,4

,

Marek Ruchała

²

and

Rafał Czepczyński

²

¹

Nuclear Medicine Department, Medical University of Warsaw, 02-091 Warsaw, Poland

²

Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, 61-701 Poznań, Poland

³

Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, 90-419 Łódź, Poland

⁴

Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital–Research Institute, 93-338 Łódź, Poland

⁵

Laboratory of Centre for Preclinical Research, Department of Research Methodology, Medical University of Warsaw, 01-445 Warsaw, Poland

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work and are both considered as the first author.

J. Clin. Med. 2024, 13(6), 1817; https://doi.org/10.3390/jcm13061817

Submission received: 30 January 2024 / Revised: 15 March 2024 / Accepted: 18 March 2024 / Published: 21 March 2024

(This article belongs to the Special Issue From Endocrine Tumors Requiring Surgery to Endocrine Issues of Different Surgical Conditions)

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Abstract

Background: Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome. Detecting the primary tumour in TIO is challenging using conventional imaging methods. This study assesses the efficacy of [⁶⁸Ga]Ga-DOTATATE PET/CT in identifying the primary tumour. Methods: Six patients with suspected TIO underwent [⁶⁸Ga]Ga-DOTATATE PET/CT. The patients’ clinical history and biochemical parameters were analysed. Results: [⁶⁸Ga]Ga-DOTATATE PET/CT successfully identified primary tumours in four patients (femoral bones for two, iliac bone for one, subcutaneous tissue of pubic region for one). Tumour removal led to clinical and laboratory improvement. In one patient, PET/CT showed rib uptake, but the biopsy was negative. One patient showed no tumour lesions on PET/CT despite clinical evidence. Two patients had focal recurrence at the primary tumour site, detected by follow-up PET/CT. Conclusions: [⁶⁸Ga]Ga-DOTATATE PET/CT is a valuable tool for detecting primary tumours in TIO, aiding in accurate diagnosis and guiding surgery, leading to improved outcomes. Further research is needed to validate these findings and explore [⁶⁸Ga]Ga-DOTATATE PET/CT in other paraneoplastic syndromes.

Keywords: tumour-induced osteomalacia (TIO); Ga-DOTATATE; osteogenic osteomalacia; phosphatonins; FGF23

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MDPI and ACS Style

Kunikowska, J.; Andryszak, N.; Skowrońska-Jóźwiak, E.; Pełka, K.; Zygmunt, A.; Lewiński, A.; Ruchała, M.; Czepczyński, R. Tumour-Induced Osteomalacia—A Long Way to the Diagnosis Facilitated by [⁶⁸Ga]Ga-DOTATATE PET/CT. J. Clin. Med. 2024, 13, 1817. https://doi.org/10.3390/jcm13061817

AMA Style

Kunikowska J, Andryszak N, Skowrońska-Jóźwiak E, Pełka K, Zygmunt A, Lewiński A, Ruchała M, Czepczyński R. Tumour-Induced Osteomalacia—A Long Way to the Diagnosis Facilitated by [⁶⁸Ga]Ga-DOTATATE PET/CT. Journal of Clinical Medicine. 2024; 13(6):1817. https://doi.org/10.3390/jcm13061817

Chicago/Turabian Style

Kunikowska, Jolanta, Natalia Andryszak, Elżbieta Skowrońska-Jóźwiak, Kacper Pełka, Arkadiusz Zygmunt, Andrzej Lewiński, Marek Ruchała, and Rafał Czepczyński. 2024. "Tumour-Induced Osteomalacia—A Long Way to the Diagnosis Facilitated by [⁶⁸Ga]Ga-DOTATATE PET/CT" Journal of Clinical Medicine 13, no. 6: 1817. https://doi.org/10.3390/jcm13061817

APA Style

Kunikowska, J., Andryszak, N., Skowrońska-Jóźwiak, E., Pełka, K., Zygmunt, A., Lewiński, A., Ruchała, M., & Czepczyński, R. (2024). Tumour-Induced Osteomalacia—A Long Way to the Diagnosis Facilitated by [⁶⁸Ga]Ga-DOTATATE PET/CT. Journal of Clinical Medicine, 13(6), 1817. https://doi.org/10.3390/jcm13061817

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Tumour-Induced Osteomalacia—A Long Way to the Diagnosis Facilitated by [⁶⁸Ga]Ga-DOTATATE PET/CT

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