2. Materials and Methods
This is a retrospective chart review from August 2011 to June 2023. Data were collected from the Maxillofacial Surgery for Children and Young Adults Division in the Head and Neck Clinic, Regional Specialized Children’s Hospital in Olsztyn, Poland. This study included patients from 1 to 25 years of age. A total of 136 procedures performed on 136 patients with complete medical records were analyzed. Patients were categorized by recipient site anatomical location, and major complications were recorded.
2.1. Procedures and Techniques
The free-flap auto-transplantation procedure began with the resection of pathology, resulting in tissue loss in the recipient site. Next, the flap was harvested from the donor site but remained connected to surrounding tissue by at least one artery and one vein. Simultaneously, the recipient site was surgically dissected to prepare the recipient artery, the facial artery, and vein, predominantly the facial vein, for anastomosis with the vascular pedicle of the free flap. The free flap was brought to the defect area and the vessels of the flap were anastomosed with the vessels of the recipient site, under the control of a microscope. After reconnection, the free flap was sutured to the defect, while the medical team monitored blood flow in the anastomosed vessels to ensure patency. Meanwhile, the donor site was primarily closed.
2.2. Terms
Iatrogenic etiology refers to cases where surgical interventions, initially intended to address a medical condition or trauma, inadvertently result in further complications or damage requiring microvascular free-flap reconstructive surgical intervention.
Lower limb nerve flap refers to a vascularized free flap containing skin, subcutaneous tissue with or without muscles and sural or tibial nerves acquired from the lower limb.
2.3. Data Collection and Statistical Analysis
Data for this study were extracted from electronic health records. A database was established for analysis. Recorded parameters included gender, age, etiology of the condition, recipient and donor sites, as well as postoperative complications.
The statistical analysis was performed using STATGRAPHICS Centurion 19 (StatPoint, Tulsa, OK, USA). The ANOVA test was utilized to determine relationships between age as a continuous variable and recipient site complications, etiology, and total flap loss. The χ2 test of independence was applied to assess relationships among categorical variables, including age groups, gender, recipient site complications, donor site, etiology, and the incidence of total flap loss. Age groups were categorized as follows: less than 5 years, 5 to 10 years, 11 to 15 years, 16 to 20 years, and over 20 years. A threshold of p < 0.05 was set to determine statistical significance.
4. Discussion
This study conducted an extensive examination of maxillofacial microvascular free-flap reconstructions in a pediatric and young adult cohort, yielding significant insights into the success rates and factors influencing outcomes. The observed success rate of 89.71% in our study, while notable, is somewhat lower compared to the success rates typically reported in the existing literature, which often exceed 94% [
1,
3,
4,
5,
9,
10,
11,
12]. In a study by Liu et al. (2018) focusing on pediatric head and neck reconstruction, a higher success rate of 95.6% was reported [
1]. However, it is essential to highlight the differences in the distribution of recipient sites between the two studies. Our research found the maxilla (55 out of 136 cases) and mandible (55 cases) to be the most common recipient sites, with the maxilla having the highest incidence of total flap loss. Notably, the success rate for mandibular reconstructions in our study was 94.55%, closely aligning with the higher success rates reported in the literature. In contrast, the study by Liu et al. primarily involved mandibular reconstructions (88 out of 135 cases), with only nine cases of maxillary reconstructions. Despite their conclusion of no significant relationship between recipient site and total flap loss, the predominance of mandibular reconstructions in their study, which aligns closely with the higher success rates in our mandibular cases, might partially explain the overall greater results observed in their findings.
In our analysis, we specifically examined the relationship between patient age and the incidence of total flap loss. It has been observed that children under ten years of age might be at a heightened risk of lower success rates in these procedures [
1]. The potential underlying factors attributed to this finding include the reduced diameter of vasculature in younger patients, arterial vasospasms, and heightened complexity in performing surgical techniques on smaller anatomical structures. Regardless of these findings, our data did not demonstrate a significant relationship between patient age and the incidence of total flap loss. Interestingly, this result is consistent with another substantial study involving 102 patients, where a similar lack of relationship between age and surgical success in microvascular reconstructions was observed [
13]. This parallel outcome in a separate large-scale study reinforces the notion that age, while an important consideration, may not be as critical a determinant of flap survival.
We investigated the potential relationship between patient gender and the incidence of total flap loss. Our examination revealed a borderline statistical significance (
p = 0.071), suggesting a tentative yet not statistically validated trend towards a higher risk of total flap loss in female patients. However, given the marginal nature of this finding, it necessitates further investigation with an expanded pediatric sample size to establish a more definitive conclusion. The literature presents varied perspectives on the influence of gender in head and neck reconstructions. For example, Loupatatzi et al. identified female gender as one of the factors associated with increased complications in head and neck cancer reconstructions, alongside pre-operative radiation therapy and extended surgery duration [
14]. In contrast, Rohleder et al. reported no significant gender-related differences in the postoperative outcomes of free-flap reconstructions in the head and neck region [
15]. It is important to note, however, that these studies predominantly involved adult populations, with mean ages notably above the pediatric range, and thereby limiting the applicability of their findings to a younger demographic.
A striking finding was the higher incidence of total flap loss in maxillary reconstructions compared to mandibular ones. Specifically, the maxilla experienced 11 cases of total flap necrosis out of 55 reconstructions, translating to a success rate of 80.36%, markedly lower than the 94.55% rate observed for mandibular reconstructions. This contrast becomes even more pronounced when compared to adult maxillary reconstruction success rates, which typically hover around 95% in the literature [
16,
17]. However, it aligns more closely with recent findings in pediatric patients, such as those reported by Burns et al. (2023), who observed a 23% total flap loss in pediatric maxillary reconstructions [
18].
The absence of any total flap loss instances in reconstructions involving soft tissues, orbital regions, and facial nerves is noteworthy. The results are consistent with the noted trend that flaps incorporating bone have a nearly five-fold higher failure rate compared to those consisting entirely of soft tissue. This is likely attributable to the fact that in bone defect reconstructions, the positioning of both the flap and its pedicle is dictated by the bony defect, offering limited flexibility for alteration [
19].
Moreover, the findings of our study hold potential utility in empowering both patients and their parents to make more informed decisions regarding free-flap microvascular reconstruction. It is an ethical obligation for physicians to provide comprehensive information to patients, encompassing diagnosis, planned treatment, postoperative complications, and success rates. Agozzino et al.’s study has contributed valuable insights into patient satisfaction and the frequency of legal claims concerning surgical procedures. The research revealed that patients who received both written consent and oral information about procedures exhibited higher satisfaction with surgical treatment compared to those who received written consent alone. Remarkably, 19.6% of individuals receiving both written and oral information reported feeling influenced to varying degrees. Notably, information regarding postoperative complications and success rates received limited attention from physicians. However, when conveyed, such information correlated with increased satisfaction with treatment and reduced patient’s anxiety [
20]. These findings underscore the importance of effective communication, providing reliable data on postoperative complications and success rates in the context of free-flap microvascular reconstructions. This could potentially enhance the satisfaction of patients and their parents while concurrently reducing the incidence of legal claims. Nevertheless, the study is subject to certain limitations. Primarily, it was conducted in general surgery units in Italy, specifically on adult patients capable of legally consenting to surgery. Consequently, the generalizability of these findings to pediatric settings is restricted to patients’ parents. Additionally, the study relied on face-to-face interviews conducted several days after patients had received written consent, introducing a potential risk of recall bias.
In our clinical practice, maxillofacial free-flap reconstructive surgeries are often necessitated by various etiologies, including oncological, traumatic, and congenital factors. These procedures not only address medical needs, such as tumor resections, but also significantly enhance craniofacial function, repair defects, and mitigate facial deformities. However, it is crucial to recognize that these surgeries invariably alter the patient’s facial appearance, underscoring the importance of properly informing both patients and parents about this fact. Parental involvement in decision-making regarding pediatric reconstructive surgery is pivotal, as some advocate for proactive surgical intervention, while others suggest waiting until the child can actively participate in the decision-making process [
21]. Incorporating intervention strategies, such as psychological support before and after surgery, as well as potential corrective cosmetic procedures, enables the effective management of their psychological burdens postoperatively and may help to tone down the negative psychosocial consequences. In particular, for appearance-sensitive adolescents, counseling pre- and postoperatively could be required to prepare them for the resultant changes. This aligns with findings from studies on head and neck reconstructions, which highlight the significant impact on patients’ psychological well-being, especially among vulnerable groups such as women with a history of anxiety or depression [
22,
23]. Similarly, research on patients with tongue cancer undergoing resection procedures emphasizes the variations in quality of life and psychological status, with more extensive surgeries often resulting in worse outcomes [
24]. Therefore, it is critical for healthcare professionals to advocate for patients considering surgery, facilitate informed decision-making, and mitigate emotional and social obstacles by openly discussing potential challenges pre-operatively, developing coping mechanisms, and educating parents and peers to reduce post-surgery psychological distress [
21].
Despite advancements in reconstructive surgery, the management of complications following flap failure remains an area with significant gaps in understanding and exploration [
25]. In our practice, the approach entails the removal of the necrotic tissue flap followed by reoperation. Additionally, thorough discussions with the patient and parents regarding the available options, potential risks, and expected outcomes are deemed essential. Identifying reversible causes for the initial flap failure is also emphasized to reduce risks in subsequent procedures. This approach requires a comprehensive assessment of the patient’s medical status aimed at optimizing their candidacy for potential subsequent interventions, with a specific focus directed towards mitigating any underlying pathological factors implicated in the initial flap failure. Given supportive findings for the efficacy of a second free flap for salvage reconstruction, this approach is preferred whenever feasible. Nonetheless, it is crucial to consider individual patient circumstances, including comorbidities and recipient site characteristics. Ultimately, the objective is to achieve optimal outcomes encompassing cosmesis, function, and complication rates, recognizing the need for a tailored approach to maximize success rates in each case [
25].
The retrospective design of this study necessitated the use of electronic medical records, which introduces the possibility of substantial data loss due to incomplete documentation from the healthcare providers or variations in medical terminology usage. Additionally, crucial information regarding free-flap dimensions and vasculature diameter was unavailable, potentially impacting the outcomes of free-flap microvascular reconstruction, including the risk of flap failure. The recommendations for further studies underscore the pressing need for standardization in both flap selection and perioperative care for pediatric patients undergoing free-flap microvascular reconstruction. Given the scarcity of studies in the literature in this area, it is imperative that future research prioritizes the development of protocols and guidelines aimed at standardizing the selection of appropriate flaps, surgical techniques, and postoperative care measures. By establishing standardized procedures, the potential for enhancing the overall success rate of these reconstructions and improving outcomes for pediatric patients becomes evident. Additionally, there is a critical need for further exploration into the harmonization of perioperative care, particularly in the realm of anesthetic management for pediatric patients undergoing such procedures. The perioperative period significantly influences complication rates and overall outcomes. Therefore, the implementation of standardized protocols for anesthesia, encompassing preoperative assessment, intraoperative monitoring, and postoperative pain management, is essential for mitigating postoperative complications effectively. Enhanced coordination and consistency in perioperative care have the potential to augment the success rate of reconstructions and contribute to better patient outcomes. Further scientific inquiry of a similar nature is warranted to validate and build upon our findings, ultimately advancing the field and improving patient care practices.