Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly
Abstract
:1. Introduction
2. Mammalian UPR
3. PERK Pathway
4. IRE1α/X Box Protein-1 (XBP-1) Pathway
5. Regulated IRE1-Dependent Decay (RIDD)
6. ATF6
7. ER Stress in the Kidney
8. Renal Cell Systems
9. ER Stress in the Diabetic Rodent Kidney
10. ER Stress in Human Diabetic Kidney Disease
11. The UPR Interacts with a Number of Signaling Cascades
11.1. Inflammation and Immunity
11.2. Mammalian Target of Rapamycin (mTOR)
11.3. Autophagy
12. Modulation of ER Stress
13. Problems with UPR/ER Stress Studies in the Kidney
14. Future Directions and Conclusions
Acknowledgments
Conflicts of Interest
References
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Cunard, R. Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly. J. Clin. Med. 2015, 4, 715-740. https://doi.org/10.3390/jcm4040715
Cunard R. Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly. Journal of Clinical Medicine. 2015; 4(4):715-740. https://doi.org/10.3390/jcm4040715
Chicago/Turabian StyleCunard, Robyn. 2015. "Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly" Journal of Clinical Medicine 4, no. 4: 715-740. https://doi.org/10.3390/jcm4040715