Investigation of the Correlation between Graves’ Ophthalmopathy and CTLA4 Gene Polymorphism
, Wei-Tzu Lin 1, Ai-Ling Hour 6 and Wei-Ting Wang 1
Thanh D. Hoang
Round 1
Reviewer 1 Report
The introduction should have more details. Discussion is too short without any clear conclusions. I did not find clear statements.
This paper is very interesting and well conducted, but in my opinion this paper has low clinical relevance. Thus I suggest another journal focusing on experimental studies.
Author Response
Point 1: The introduction should have more details. Discussion is too short without any clear conclusions. I did not find clear statements. This paper is very interesting and well conducted, but in my opinion this paper has low clinical relevance. Thus I suggest another journal focusing on experimental studies.
Response 1: We appreciated the reviewer’s comment. We have added more details to introduction and discussion. Clear statements were made in conclusions.
Author Response File: 
Author Response.docx
Reviewer 2 Report
A very well written paper. Very interesting!
1-Please reformat the references to be more consistent.
2-Table 2 - need to add the characteristics of the controls.
3-Line 93 - Werner (reference 13), not reference 6.
4-Paragraph 2 of Discussion, reference 21 should be listed before reference 22 (need to re-number).
5-Are there any associations with increased risk of thyroid nodules or thyroid cancers in patients with GD or GO.
6-Table 7: delete d.=1 (3rd paragraph).
Author Response
A very well written paper. Very interesting!
Author reply: We appreciated the reviewer’s comment.
Point 1: Please reformat the references to be more consistent.
Response 1: We have revised them.
Point 2: Table 2 - need to add the characteristics of the controls.
Response 2: We have added and revised them in the study subjects section of experimental section.
Point 3: Line 93 - Werner (reference 13), not reference 6.
Response 3: We have revised them.
Point 4: Paragraph 2 of Discussion, reference 21 should be listed before reference 22 (need to re-number).
Response 4: We have revised them.
Point 5: Are there any associations with increased risk of thyroid nodules or thyroid cancers in patients with GD or GO.
Response 5: Studies have suggested an increased risk of thyroid malignancy in Graves' disease. (Staniforth JU, Erdirimanne S, Eslick GD. Thyroid carcinoma in Graves' disease: A meta-analysis. Int J Surg. 2016 Mar;27:118-25.)
Point 6: Table 7: delete d.=1 (3rd paragraph).
Response 6: We have revised them.
Author Response File: Author Response.docx
