Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans

Gómez-Bañuelos, Eduardo; Mukherjee, Amarshi; Darrah, Erika; Andrade, Felipe

doi:10.3390/jcm8091309

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Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans

by

Eduardo Gómez-Bañuelos

,

Amarshi Mukherjee

,

Erika Darrah

and

Felipe Andrade

^*

Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA

^*

Author to whom correspondence should be addressed.

J. Clin. Med. 2019, 8(9), 1309; https://doi.org/10.3390/jcm8091309

Submission received: 30 July 2019 / Revised: 20 August 2019 / Accepted: 21 August 2019 / Published: 26 August 2019

(This article belongs to the Special Issue Periodontitis: From Dysbiotic Microbial Immune Response to Systemic Inflammation)

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Abstract

Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology characterized by immune-mediated damage of synovial joints and antibodies to citrullinated antigens. Periodontal disease, a bacterial-induced inflammatory disease of the periodontium, is commonly observed in RA and has implicated periodontal pathogens as potential triggers of the disease. In particular, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans have gained interest as microbial candidates involved in RA pathogenesis by inducing the production of citrullinated antigens. Here, we will discuss the clinical and mechanistic evidence surrounding the role of these periodontal bacteria in RA pathogenesis, which highlights a key area for the treatment and preventive interventions in RA.

Keywords: Rheumatoid arthritis; Porphyromonas gingivalis; Aggregatibacter actinomycetemcomitans; periodontitis; periodontal disease; citrullination; peptidylarginine deiminase; ACPA; anti-CCP

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MDPI and ACS Style

Gómez-Bañuelos, E.; Mukherjee, A.; Darrah, E.; Andrade, F. Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. J. Clin. Med. 2019, 8, 1309. https://doi.org/10.3390/jcm8091309

AMA Style

Gómez-Bañuelos E, Mukherjee A, Darrah E, Andrade F. Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. Journal of Clinical Medicine. 2019; 8(9):1309. https://doi.org/10.3390/jcm8091309

Chicago/Turabian Style

Gómez-Bañuelos, Eduardo, Amarshi Mukherjee, Erika Darrah, and Felipe Andrade. 2019. "Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans" Journal of Clinical Medicine 8, no. 9: 1309. https://doi.org/10.3390/jcm8091309

APA Style

Gómez-Bañuelos, E., Mukherjee, A., Darrah, E., & Andrade, F. (2019). Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. Journal of Clinical Medicine, 8(9), 1309. https://doi.org/10.3390/jcm8091309

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans

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