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Article

One-Fifth of Children with Sickle Cell Anemia Show Exercise-Induced Hemoglobin Desaturation: Rate of Perceived Exertion and Role of Blood Rheology

by
Valentine Brousse
1,2,3,*,
Corinne Pondarre
4,
Cecile Arnaud
4,
Annie Kamden
4,
Mariane de Montalembert
1,2,
Benedicte Boutonnat-Faucher
1,
Hélène Bourdeau
5,
Keyne Charlot
6,
David Grévent
7,
Suzanne Verlhac
8,
Lydie da Costa
2,3,5,9 and
Philippe Connes
2,10,11
1
Service de Pédiatrie Générale et Maladies infectieuses, Hôpital Necker Enfants Malades, AP-HP, 75015 Paris, France
2
LABEX GR-Ex, F-75015 Paris, France
3
UMR_S1134, Inserm, Institut National de la transfusion sanguine, 75015 Paris, France
4
Service de Pédiatrie, Centre Intercommunal de Créteil, 94000 Créteil, France
5
Service d’Hématologie Biologique, Hôpital Robert Debré, AP-HP, 75019 Paris, France
6
Unité de Physiologie des Exercices et Activités en Conditions Extrêmes, Département Environnements Opérationnels Institut de Recherche Biomédicale des Armées, 91220 Brétigny-sur-Orge, France
7
Service d’Imagerie Pédiatrique, Hôpital Necker Enfants Malades, AP-HP, F-75015 Paris, France
8
Service de Radiologie, Centre Intercommunal de Créteil, 94000 Créteil, France
9
Paris University, F-75010 Paris, France
10
Equipe «Biologie Vasculaire et du Globule Rouge», Laboratoire LIBM EA7424, Université Claude Bernard Lyon 1, 69100 Villeurbanne, France
11
Institut Universitaire de France, 75015 Paris, France
 
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*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 133; https://doi.org/10.3390/jcm9010133
Submission received: 19 November 2019 / Revised: 18 December 2019 / Accepted: 28 December 2019 / Published: 3 January 2020
(This article belongs to the Special Issue Sickle Cell Anemia: From Genetic Epidemiology to New Therapeutic Strategies)
Review Reports Versions Notes

Abstract

Perceived exertion is an important self-limiting factor influencing functional capacity in patients with sickle cell anemia (SCA). Exercise-related hemoglobin desaturation (EHD) may occur during a six-minute walking test (6MWT) and could influence the perceived rate of exertion. The aims of this study were (1) to compare the 6MWT responses (heart rate, perceived rate of exertion, and distance covered) between SCA children with and without EHD, and (2) to test the associations between EHD and several biological/physiological parameters. Nine of 51 SCA children (18%) at steady state (mean age 11.9 ± 3.8 years) exhibited EHD at the end of the 6MWT. The rate of perceived exertion increased with exercise in the two groups, but reached higher values in the EHD group. Heart rate and performance during the 6MWT did not differ between the two groups. The magnitude of change in SpO2 during the 6MWT was independently associated with the red blood cell (RBC) deformability and RBC aggregates strength. This study demonstrates that SCA children with EHD during a 6MWT have a higher rate of perceived exertion than non-EHD children despite a similar physiological demand, and that abnormal RBC rheology determinants appear to be significant contributors.
Keywords: sickle cell disease; hypoxemia; six-minute walk test; children sickle cell disease; hypoxemia; six-minute walk test; children

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MDPI and ACS Style

Brousse, V.; Pondarre, C.; Arnaud, C.; Kamden, A.; de Montalembert, M.; Boutonnat-Faucher, B.; Bourdeau, H.; Charlot, K.; Grévent, D.; Verlhac, S.; et al. One-Fifth of Children with Sickle Cell Anemia Show Exercise-Induced Hemoglobin Desaturation: Rate of Perceived Exertion and Role of Blood Rheology. J. Clin. Med. 2020, 9, 133. https://doi.org/10.3390/jcm9010133

AMA Style

Brousse V, Pondarre C, Arnaud C, Kamden A, de Montalembert M, Boutonnat-Faucher B, Bourdeau H, Charlot K, Grévent D, Verlhac S, et al. One-Fifth of Children with Sickle Cell Anemia Show Exercise-Induced Hemoglobin Desaturation: Rate of Perceived Exertion and Role of Blood Rheology. Journal of Clinical Medicine. 2020; 9(1):133. https://doi.org/10.3390/jcm9010133

Chicago/Turabian Style

Brousse, Valentine, Corinne Pondarre, Cecile Arnaud, Annie Kamden, Mariane de Montalembert, Benedicte Boutonnat-Faucher, Hélène Bourdeau, Keyne Charlot, David Grévent, Suzanne Verlhac, and et al. 2020. "One-Fifth of Children with Sickle Cell Anemia Show Exercise-Induced Hemoglobin Desaturation: Rate of Perceived Exertion and Role of Blood Rheology" Journal of Clinical Medicine 9, no. 1: 133. https://doi.org/10.3390/jcm9010133

APA Style

Brousse, V., Pondarre, C., Arnaud, C., Kamden, A., de Montalembert, M., Boutonnat-Faucher, B., Bourdeau, H., Charlot, K., Grévent, D., Verlhac, S., da Costa, L., & Connes, P. (2020). One-Fifth of Children with Sickle Cell Anemia Show Exercise-Induced Hemoglobin Desaturation: Rate of Perceived Exertion and Role of Blood Rheology. Journal of Clinical Medicine, 9(1), 133. https://doi.org/10.3390/jcm9010133

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