Aging Is Positively Associated with Peri-Sinus Lymphatic Space Volume: Assessment Using 3T Black-Blood MRI
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Image Acquisition
2.3. Image Analyses
2.4. Segmentation of Dura-Associated Lymphatics
2.5. Brain Volume Analysis
2.6. Statistical Analyses
3. Results
3.1. Participant Characteristics
3.2. Aging and Its Association with Normalized Peri-Sinus Lymphatic Volume
3.3. Differences Regarding Effects of Aging on Normalized Peri-Sinus Lymphatic Volume Based on Sex
3.4. Interrater Reliability of Peri-Sinus Lymphatic Space Volume Measurements
4. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Variable | Total Patients n = 165 | Non-Elderly n = 93 | Elderly n = 72 | p Value |
---|---|---|---|---|
Sex (M:F) | 91:74 | 45:48 | 46: 26 | 0.058 |
Age (y) | 62.1 ± 10.9 | 54.6 ± 7.7 | 71.8 ± 5.2 | <0.001 |
Underlying disease | 0.028 | |||
Lung cancer | 115 (69.7%) | 57 (61.3%) | 58 (80.6%) | |
Breast cancer | 20 (12.1%) | 16 (17.2%) | 4 (5.6%) | |
Other | 20 (12.1%) | 12 (12.9%) | 8 (11.1%) | |
None | 10 (6.1%) | 8 (8.6%) | 2 (2.8%) | |
Hypertension | 48 (29.1%) | 15 (16.1%) | 33 (45.8%) | <0.001 |
Diabetes mellitus | 36 (21.8%) | 17 (18.3%) | 19 (26.4%) | 0.144 |
Previous chemotherapy | 61 (37.0%) | 31 (33.3%) | 30 (41.7%) | 0.271 |
Total Fazekas score | 2.1 ± 1.4 | 1.5 ± 0.9 | 2.9 ± 1.6 | <0.001 |
ePVS-BG (+) | 18 (10.9%) | 3 (3.2%)18 | 15 (20.8%) | <0.001 |
ePVS-CSO (+) | 60 (36.4%) | 21 (22.6%) | 39 (54.9%) | <0.001 |
Intracranial volume (cm3) | 1401.1 ± 131.2 | 1402.0 ± 140.3 | 1399.9 ± 119.3 | 0.918 |
Normalized dural lymphatic volume (mm3) | 4028.0 ± 1529.8 | 3726.5 ± 1513.9 | 4417.6 ± 1470.6 | 0.004 |
Variables | Univariate | Multivariate | ||
---|---|---|---|---|
β Coefficient | p-Value | β Coefficient | p-Value | |
Age | 34.0 (12.9–55.1) | 0.002 | 28.4 (5.7–51.2) | 0.015 |
Male sex | 1158.1 (719.0–1597.3) | <0.001 | 672.4 (109.9–1234.9) | 0.019 |
DM | 197.9 (−372.3 to 768.3) | 0.494 | - | - |
HTN | 469.3 (−44.9 to 983.5) | 0.073 | −2.8 (−517.6 to 512.0) | 0.991 |
ePVS-CSO (+) | 510.2 (26.8–993.6) | 0.039 | 0.415 (−490.1 to 491.0) | 0.999 |
ePVS-BG (+) | 522.5 (−229.8 to 1274.8) | 0.172 | - | - |
Intracranial volume (cm3) | 3.9 (2.2–5.6) | <0.001 | 2.3 (0.16–4.4) | 0.035 |
Brain metastasis | −86.3 (−570.4 to 397.4) | 0.724 | - | - |
Cancer type | ||||
None | - | - | - | - |
Lung cancer | −67.4 (−1052.4 to 917.6) | 0.893 | - | - |
Other cancer | −715.1 (−1771.4 to 341.2) | 0.183 | - | - |
Previous Chemotherapy | −313.5 (−799.7 to 172.8) | 0.205 | - | - |
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Park, M.; Kim, J.W.; Ahn, S.J.; Cha, Y.J.; Suh, S.H. Aging Is Positively Associated with Peri-Sinus Lymphatic Space Volume: Assessment Using 3T Black-Blood MRI. J. Clin. Med. 2020, 9, 3353. https://doi.org/10.3390/jcm9103353
Park M, Kim JW, Ahn SJ, Cha YJ, Suh SH. Aging Is Positively Associated with Peri-Sinus Lymphatic Space Volume: Assessment Using 3T Black-Blood MRI. Journal of Clinical Medicine. 2020; 9(10):3353. https://doi.org/10.3390/jcm9103353
Chicago/Turabian StylePark, Mina, Jin Woo Kim, Sung Jun Ahn, Yoon Jin Cha, and Sang Hyun Suh. 2020. "Aging Is Positively Associated with Peri-Sinus Lymphatic Space Volume: Assessment Using 3T Black-Blood MRI" Journal of Clinical Medicine 9, no. 10: 3353. https://doi.org/10.3390/jcm9103353