Incidence of Melanoma in Catalonia, Spain, Is Rapidly Increasing in the Elderly Population. A Multicentric Cohort Study
Abstract
:1. Introduction
2. Material and Methods
3. Results
4. Discussion
Strengths and Limitations
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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2008–2009 (N = 1543) | 2010–2011 (N = 1500) | 2012–2013 (N = 1696) | 2014–2015 (N = 1906) | 2016–2017 (N = 2108) | Total (N = 8753) | p Value | |
---|---|---|---|---|---|---|---|
Gender | 0.496 | ||||||
Female | 789 (51.1%) | 751 (50.1%) | 897 (52.9%) | 971 (50.9%) | 1060 (50.3%) | 4468 (51.0%) | |
Male | 754 (48.9%) | 749 (49.9%) | 799 (47.1%) | 935 (49.1%) | 1048 (49.7%) | 4285 (49.0%) | |
Age | <0.001 | ||||||
Mean (SD) | 58.2 (17.3) | 59.6 (17.3) | 60.4 (17.3) | 61.9 (17.0) | 63.3 (17.1) | 60.9 (17.3) | |
Staging | <0.001 | ||||||
In situ | 466 (30.2%) | 476 (31.7%) | 524 (30.9%) | 638 (33.5%) | 792 (37.6%) | 2896 (33.1%) | |
invasive | 1077 (69.8%) | 1024 (68.3%) | 1172 (69.1%) | 1268 (66.5%) | 1316 (62.4%) | 5857 (66.9%) | |
Breslow index | 0.219 | ||||||
Mean (SD) | 2.2 (6.0) | 2.4 (4.5) | 2.4 (3.6) | 2.2 (4.1) | 2.1 (3.2) | 2.3 (4.3) | |
Tumour Location | 0.001 | ||||||
Trunk | 551 (41.4%) | 527 (40.2%) | 573 (38.8%) | 740 (43.1%) | 888 (45.1%) | 3279 (42.0%) | |
Head and neck | 278 (20.9%) | 302 (23.1%) | 310 (21.0%) | 371 (21.6%) | 412 (20.9%) | 1673 (21.4%) | |
Lower limbs | 254 (19.1%) | 231 (17.6%) | 280 (18.9%) | 268 (15.6%) | 298 (15.1%) | 1331 (17.1%) | |
Upper limbs | 145 (10.9%) | 148 (11.3%) | 190 (12.9%) | 219 (12.8%) | 237 (12.0%) | 939 (12.0%) | |
Acral | 97 (7.3%) | 85 (6.5%) | 107 (7.2%) | 92 (5.4%) | 107 (5.4%) | 488 (6.3%) | |
Mucosa | 7 (0.5%) | 17 (1.3%) | 18 (1.2%) | 27 (1.6%) | 27 (1.4%) | 96 (1.2%) | |
Missing values | 211 | 190 | 218 | 189 | 139 | 947 | |
Histological subtype | <0.001 | ||||||
SSM | 871 (63.9%) | 806 (61.7%) | 884 (60.2%) | 965 (59.5%) | 1011 (55.1%) | 4537 (59.7%) | |
LMM | 190 (13.9%) | 183 (14.0%) | 227 (15.5%) | 306 (18.9%) | 414 (22.6%) | 1320 (17.4%) | |
Nodular | 180 (13.2%) | 176 (13.5%) | 193 (13.1%) | 180 (11.1%) | 189 (10.3%) | 918 (12.1%) | |
Acral lentiginous | 65 (4.8%) | 51 (3.9%) | 85 (5.8%) | 73 (4.5%) | 74 (4.0%) | 348 (4.6%) | |
Mucosal | 4 (0.3%) | 13 (1.0%) | 11 (0.7%) | 16 (1.0%) | 20 (1.1%) | 64 (0.8%) | |
Desmoplastic | 10 (0.7%) | 14 (1.1%) | 10 (0.7%) | 8 (0.5%) | 15 (0.8%) | 57 (0.8%) | |
Spitzoid | 3 (0.2%) | 1 (0.1%) | 8 (0.5%) | 11 (0.7%) | 21 (1.1%) | 44 (0.6%) | |
Nevoid | 3 (0.2%) | 1 (0.1%) | 1 (0.1%) | 4 (0.2%) | 8 (0.4%) | 17 (0.2%) | |
Other | 37 (2.7%) | 62 (4.7%) | 50 (3.4%) | 60 (3.7%) | 82 (4.5%) | 291 (3.8%) | |
Missing values | 180 | 193 | 227 | 283 | 274 | 1157 |
Year | Population | Cases | Crude Rate | ASIR | 95% CI |
---|---|---|---|---|---|
Melanoma (Including In Situ Melanoma) | |||||
2008 | 7,298,313 | 792 | 10.85 | 11.56 | [11.38–11.75] |
2009 | 7,416,605 | 751 | 10.13 | 10.80 | [10.62–10.97] |
2010 | 7,462,044 | 727 | 9.74 | 10.35 | [10.18–10.52] |
2011 | 7,501,853 | 773 | 10.30 | 10.88 | [10.7–11.06] |
2012 | 7,515,398 | 809 | 10.76 | 11.25 | [11.07–11.43] |
2013 | 7,478,968 | 887 | 11.86 | 12.30 | [12.11–12.49] |
2014 | 7,433,894 | 887 | 11.93 | 12.23 | [12.05–12.43] |
2015 | 7,424,754 | 1019 | 13.72 | 13.86 | [13.65–14.06] |
2016 | 7,448,332 | 1064 | 14.29 | 14.34 | [14.14–14.55] |
2017 | 7,496,276 | 1044 | 13.93 | 13.78 | [13.57–13.98] |
Invasive melanoma | |||||
2008 | 7,298,313 | 560 | 7.67 | 8.19 | [8.04–8.35] |
2009 | 7,416,605 | 517 | 6.97 | 7.38 | [7.23–7.52] |
2010 | 7,462,044 | 481 | 6.45 | 6.83 | [6.7–6.98] |
2011 | 7,501,853 | 543 | 7.24 | 7.64 | [7.49–7.79] |
2012 | 7,515,398 | 556 | 7.40 | 7.73 | [7.58–7.88] |
2013 | 7,478,968 | 616 | 8.24 | 8.57 | [8.41–8.73] |
2014 | 7,433,894 | 585 | 7.87 | 8.04 | [7.89–8.2] |
2015 | 7,424,754 | 683 | 9.20 | 9.23 | [9.06–9.4] |
2016 | 7,448,332 | 698 | 9.37 | 9.32 | [9.16–9.49] |
2017 | 7,496,276 | 618 | 8.24 | 8.08 | [7.92–8.24] |
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Podlipnik, S.; Carrera, C.; Boada, A.; Richarz, N.; Marcoval, J.; Ferreres, J.R.; Bodet, D.; Martí, R.M.; Segura, S.; Sabat, M.; et al. Incidence of Melanoma in Catalonia, Spain, Is Rapidly Increasing in the Elderly Population. A Multicentric Cohort Study. J. Clin. Med. 2020, 9, 3396. https://doi.org/10.3390/jcm9113396
Podlipnik S, Carrera C, Boada A, Richarz N, Marcoval J, Ferreres JR, Bodet D, Martí RM, Segura S, Sabat M, et al. Incidence of Melanoma in Catalonia, Spain, Is Rapidly Increasing in the Elderly Population. A Multicentric Cohort Study. Journal of Clinical Medicine. 2020; 9(11):3396. https://doi.org/10.3390/jcm9113396
Chicago/Turabian StylePodlipnik, Sebastian, Cristina Carrera, Aram Boada, Nina Richarz, Joaquim Marcoval, Josep Ramón Ferreres, Domingo Bodet, Rosa María Martí, Sonia Segura, Mireia Sabat, and et al. 2020. "Incidence of Melanoma in Catalonia, Spain, Is Rapidly Increasing in the Elderly Population. A Multicentric Cohort Study" Journal of Clinical Medicine 9, no. 11: 3396. https://doi.org/10.3390/jcm9113396