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Article

Analysis of Arterial Stiffness and Sexual Function after Adding on PCSK9 Inhibitor Treatment in Male Patients with Familial Hypercholesterolemia: A Single Lipid Center Real-World Experience

by
Roberto Scicali
1,2,*,†,
Giorgio Ivan Russo
3,†,
Marina Di Mauro
3,
Flavia Manuele
1,2,
Grazia Di Marco
1,2,
Antonino Di Pino
1,2,
Viviana Ferrara
1,2,
Agata Maria Rabuazzo
1,2,
Salvatore Piro
1,2,
Giuseppe Morgia
3 and
Francesco Purrello
1,2
1
Department of Clinical and Experimental Medicine, University of Catania, 95100 Catania, Italy
2
Internal Medicine, Garibaldi Hospital, 95122 Catania, Italy
3
Urology Section, Department of Surgery, University of Catania, 95100 Catania, Italy
*
Author to whom correspondence should be addressed.
†
These authors equally contributed to the article.
J. Clin. Med. 2020, 9(11), 3597; https://doi.org/10.3390/jcm9113597
Submission received: 14 October 2020 / Revised: 5 November 2020 / Accepted: 6 November 2020 / Published: 8 November 2020
(This article belongs to the Special Issue Pharmacological Lipid Strategies for Cardiovascular Disease Prevention)
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Abstract

Familial hypercholesterolemia (FH) subjects have high low-density lipoprotein cholesterol (LDL-C) and may be at high risk of erectile dysfunction and atherosclerotic cardiovascular diseases. We evaluated the effect of PCSK9-i on sexual function evaluated by the Male Sexual Health Questionnaire (MSHQ) and the International Index of Erectile Function (IIEF-5) questionnaire and on pulse wave velocity (PWV) in FH male subjects. In this prospective observational study, we evaluated 30 FH male patients on high-intensity statins plus ezetimibe and with an LDL-C off-target. All patients added PCSK9-i treatment and obtained clinical assessment at baseline and after six months of PCSK9-i. As expected, LDL-C significantly decreased after adding-on PCSK9-i (−48.73%, p < 0.001). MSHQ and PWV significantly improved after adding-on PCSK9-i (for MSHQ 93.63 ± 6.28 vs. 105.41 ± 5.86, p < 0.05; for PWV 9.86 ± 1.51 vs. 7.7 ± 1.42, p < 0.05); no significant change of IIEF-5 was found. Finally, a simple regression showed that ∆ MSHQ was significantly associated with ∆ LDL-C and ∆ PWV (p value for both <0.05). In conclusion, PCSK9-i therapy significantly improves lipid profile, PWV, and sexual function in FH male patients; our results support the favorable function of PCSK9-i on these parameters.
Keywords: familial hypercholesterolemia; PCSK9 inhibitors; arterial stiffness; sexual function; cardiovascular risk familial hypercholesterolemia; PCSK9 inhibitors; arterial stiffness; sexual function; cardiovascular risk

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MDPI and ACS Style

Scicali, R.; Russo, G.I.; Di Mauro, M.; Manuele, F.; Di Marco, G.; Di Pino, A.; Ferrara, V.; Rabuazzo, A.M.; Piro, S.; Morgia, G.; et al. Analysis of Arterial Stiffness and Sexual Function after Adding on PCSK9 Inhibitor Treatment in Male Patients with Familial Hypercholesterolemia: A Single Lipid Center Real-World Experience. J. Clin. Med. 2020, 9, 3597. https://doi.org/10.3390/jcm9113597

AMA Style

Scicali R, Russo GI, Di Mauro M, Manuele F, Di Marco G, Di Pino A, Ferrara V, Rabuazzo AM, Piro S, Morgia G, et al. Analysis of Arterial Stiffness and Sexual Function after Adding on PCSK9 Inhibitor Treatment in Male Patients with Familial Hypercholesterolemia: A Single Lipid Center Real-World Experience. Journal of Clinical Medicine. 2020; 9(11):3597. https://doi.org/10.3390/jcm9113597

Chicago/Turabian Style

Scicali, Roberto, Giorgio Ivan Russo, Marina Di Mauro, Flavia Manuele, Grazia Di Marco, Antonino Di Pino, Viviana Ferrara, Agata Maria Rabuazzo, Salvatore Piro, Giuseppe Morgia, and et al. 2020. "Analysis of Arterial Stiffness and Sexual Function after Adding on PCSK9 Inhibitor Treatment in Male Patients with Familial Hypercholesterolemia: A Single Lipid Center Real-World Experience" Journal of Clinical Medicine 9, no. 11: 3597. https://doi.org/10.3390/jcm9113597

APA Style

Scicali, R., Russo, G. I., Di Mauro, M., Manuele, F., Di Marco, G., Di Pino, A., Ferrara, V., Rabuazzo, A. M., Piro, S., Morgia, G., & Purrello, F. (2020). Analysis of Arterial Stiffness and Sexual Function after Adding on PCSK9 Inhibitor Treatment in Male Patients with Familial Hypercholesterolemia: A Single Lipid Center Real-World Experience. Journal of Clinical Medicine, 9(11), 3597. https://doi.org/10.3390/jcm9113597

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