Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients for the Treatment of Severe Aortic Stenosis
Abstract
:1. Introduction
2. Methods
2.1. Search Strategy and Study Selection
2.2. Data Abstraction, Validity Assessment and Analysis
2.3. Statistical Analysis
3. Results
3.1. Search Results
3.2. Study Characteristics
3.3. Study Outcomes
4. Discussion
5. Limitations
6. Conclusions
Supplementary Materials
Author Contributions
Conflicts of Interest
References
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Study | Year | Location | N | Study Design | Primary Endpoint | Mortality Reported | Valve Type | Randomization | Follow-Up (Years) |
---|---|---|---|---|---|---|---|---|---|
NOTION | 2015 | Multicenter | 280 | RCT | Death from any cause, stroke, or myocardial infarction | Yes | CoreValve (Medtronic) | TAVR vs. SAVR | 1 |
ELRT | 2019 | Multicenter | 1403 | RCT | Death from any cause or disabling stroke | Yes | CoreValve, Evolut R, or Evolut PRO (Medtronic) | TAVR vs. SAVR | 1 |
PARTNER 3 | 2019 | Multicenter | 950 | RCT | death from any cause, stroke, or rehospitalization | Yes | Sapien 3 (Edwards) | TAVR vs. SAVR | 1 |
NOTION 2015 | ELRT 2019 | PARTNER 3 2019 | ||||
---|---|---|---|---|---|---|
TAVR | SAVR | TAVR | SAVR | TAVR | SAVR | |
N of patients, n | 145 | 135 | 725 | 678 | 496 | 454 |
Age, yrs | 79.2 | 79 | 74.1 | 73.6 | 73.3 | 73.6 |
Male, % | 53.8 | 52.6 | 64 | 66.2 | 67.5 | 71.1 |
Creatinine > 2 mg/dL, % | 1.4 | 0.7 | 0.4 | 0.1 | 0.2 | 0.2 |
Peripheral vascular disease, % | 4.1 | 6.7 | 7.5 | 8.3 | 6.9 | 7.3 |
Diabetes, % | 17.9 | 20.7 | 31.4 | 30.5 | 31.2 | 30.2 |
Chronic lung disease, % | 11.7 | 11.9 | 15 | 18 | 5.1 | 6.2 |
Prior Stroke, % | 16.6 | 16.3 | 10.2 | 11.8 | 3.4 | 5.1 |
Prior MI, % | 5.5 | 4.4 | 6.6 | 4.9 | 5.7 | 5.8 |
Prior AF, % | 27.8 | 25.6 | 15.4 | 14.5 | 15.7 | 18.8 |
STS score, % | 2.9 | 3.1 | 1.9 | 1.9 | 1.9 | 1.9 |
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Polimeni, A.; Sorrentino, S.; De Rosa, S.; Spaccarotella, C.; Mongiardo, A.; Sabatino, J.; Indolfi, C. Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients for the Treatment of Severe Aortic Stenosis. J. Clin. Med. 2020, 9, 439. https://doi.org/10.3390/jcm9020439
Polimeni A, Sorrentino S, De Rosa S, Spaccarotella C, Mongiardo A, Sabatino J, Indolfi C. Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients for the Treatment of Severe Aortic Stenosis. Journal of Clinical Medicine. 2020; 9(2):439. https://doi.org/10.3390/jcm9020439
Chicago/Turabian StylePolimeni, Alberto, Sabato Sorrentino, Salvatore De Rosa, Carmen Spaccarotella, Annalisa Mongiardo, Jolanda Sabatino, and Ciro Indolfi. 2020. "Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients for the Treatment of Severe Aortic Stenosis" Journal of Clinical Medicine 9, no. 2: 439. https://doi.org/10.3390/jcm9020439