Urine Proteomic Study in OAB Patients—Preliminary Report
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Parameter | OAB Group (n = 8) | Control Group (n = 8) | p Value |
---|---|---|---|
Age (years) | 57.4 | 62.0 | 0.08 |
BMI (kg/m2) | 24.1 | 25.2 | 0.69 |
Parity (n) | 1.9 | 1.5 | 0.44 |
Experiment 1 (ExpOABK_01) | ||||||
No. | Protein | q Value | Ratio | Fold Change | Peptides | Description |
1 | P25311 | 0.0002 | 1.46 | 1.46 | 40 | Zinc-alpha-2-glycoprotein |
2 | P12830 | 0.0002 | 1.45 | 1.45 | 28 | Cadherin-1 |
3 | P06396 | 0.0002 | 1.37 | 1.37 | 30 | Gelsolin |
4 | P02760 | 0.0009 | 1.15 | 1.15 | 50 | Protein AMBP |
5 | P41222 | 0.00391 | 1.21 | 1.21 | 53 | Prostaglandin-H2 D-isomerase |
6 | P08246 | 0.00397 | 0.43 | 2.35 | 4 | Neutrophil elastase |
7 | Q9Y279 | 0.00465 | 2.17 | 2.17 | 4 | V-set and immunoglobulin domain-containing protein 4 |
8 | P19320 | 0.00723 | 1.36 | 1.36 | 10 | Vascular cell adhesion molecule 1 |
9 | P0DOX8 | 0.06346 | 1.1 | 1.1 | 32 | Immunoglobulin lambda-1 light chain |
10 | Q5T013 | 0.02613 | 1.25 | 1.25 | 18 | Putative hydroxypyruvate isomerase |
11 | P01619 | 0.02754 | 1.19 | 1.19 | 9 | Immunoglobulin kappa variable 3–20 |
Experiment 2 (ExpOABK_02) | ||||||
No. | Protein | q Value | Ratio | Fold Change | Peptides | Description |
1 | P98160 | 0.00018 | 0.76 | 1.32 | 60 | Basement membrane-specific heparan sulfate proteoglycan core protein |
2 | Q9HCU0 | 0.00018 | 0.49 | 2.05 | 5 | Endosialin |
3 | P02787 | 0.00018 | 1.4 | 1.4 | 47 | Serotransferrin |
4 | P00738 | 0.00018 | 2.07 | 2.07 | 13 | Haptoglobin |
5 | P20742 | 0.00029 | 1.36 | 1.36 | 43 | Pregnancy zone protein |
6 | P0DOX7 | 0.00172 | 1.23 | 1.23 | 34 | Immunoglobulin kappa light chain |
7 | P06870 | 0.00652 | 0.53 | 1.87 | 7 | Kallikrein-1 |
8 | P05155 | 0.00704 | 0.75 | 1.34 | 38 | Plasma protease C1 inhibitor |
9 | P04083 | 0.00735 | 1.53 | 1.53 | 15 | Annexin A1 |
10 | O95460 | 0.01472 | 0.47 | 2.11 | 3 | Matrilin-4 |
11 | P02750 | 0.01886 | 1.37 | 1.37 | 25 | Leucine-rich alpha-2-glycoprotein |
12 | P36957 | 0.01934 | 0.34 | 2.97 | 2 | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex. mitochondrial |
13 | P13647 | 0.01991 | 0.56 | 1.78 | 7 | Keratin. type II cytoskeletal 5 |
14 | P0DOX5 | 0.01992 | 1.33 | 1.33 | 11 | Immunoglobulin gamma-1 heavy chain |
15 | P19320 | 0.02104 | 1.24 | 1.24 | 12 | Vascular cell adhesion molecule 1 |
16 | P01861 | 0.02134 | 1.47 | 1.47 | 9 | Immunoglobulin heavy constant gamma 4 |
17 | Q99715 | 0.03727 | 0.8 | 1.26 | 27 | Collagen alpha-1(XII) chain |
18 | P22105 | 0.03768 | 0.78 | 1.28 | 38 | Tenascin-X |
Sample | Total Queries | Queries | Peptides | Proteins |
---|---|---|---|---|
ExpOABK_01 | 1,388,534 | 19,605 | 5529 | 1138 |
ExpOABK_02 | 1,434,226 | 22,496 | 7003 | 1401 |
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Futyma, K.; Nowakowski, Ł.; Ziętek-Strobl, A.; Kamińska, A.; Taoussi, N.; Rechberger, T. Urine Proteomic Study in OAB Patients—Preliminary Report. J. Clin. Med. 2020, 9, 1389. https://doi.org/10.3390/jcm9051389
Futyma K, Nowakowski Ł, Ziętek-Strobl A, Kamińska A, Taoussi N, Rechberger T. Urine Proteomic Study in OAB Patients—Preliminary Report. Journal of Clinical Medicine. 2020; 9(5):1389. https://doi.org/10.3390/jcm9051389
Chicago/Turabian StyleFutyma, Konrad, Łukasz Nowakowski, Alicja Ziętek-Strobl, Aleksandra Kamińska, Nadia Taoussi, and Tomasz Rechberger. 2020. "Urine Proteomic Study in OAB Patients—Preliminary Report" Journal of Clinical Medicine 9, no. 5: 1389. https://doi.org/10.3390/jcm9051389