Effects of Prolonged Type 2 Diabetes on the Inner Retinal Layer and Macular Microvasculature: An Optical Coherence Tomography Angiography Study
Abstract
:1. Introduction
2. Methods
2.1. Patients
2.2. OCT Measurements
2.3. VD Measurement Using OCTA
2.4. Statistical Analysis
3. Results
3.1. Demographics
3.2. GC-IPL Thickness in Each Group
3.3. Superficial Macular VD in Each Group
3.4. Factors Associated with Superficial Macular VD in T2DM Patients
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Normal Controls (n = 97) | DM Group 1 (n = 92) | DM Group 2 (n = 57) | p-Value | |
---|---|---|---|---|
Age (mean ± SE, years) | 63.82 ± 0.44 | 62.43 ± 1.09 | 64.12 ± 1.11 | 0.356 |
Sex (male, %) | 44 (45.4%) | 35 (38.0%) | 28 (49.1%) | 0.371 |
Laterality (right, %) | 55 (56.7%) | 46 (50.0%) | 28 (49.1%) | 0.555 |
BCVA (mean ± SE, logMAR) | −0.019 ± 0.006 | 0.002 ± 0.007 | 0.003 ± 0.007 | 0.027 |
SE (mean ± SE, diopters) | 0.06 ± 0.11 | −0.36 ± 0.14 | 0.07 ± 0.18 | 0.060 |
IOP (mean ± SE, mmHg) | 15.64 ± 0.27 | 15.96 ± 0.32 | 15.47 ± 0.36 | 0.600 |
Axial length (mean ± SE, mm) | 23.57 ± 0.07 | 23.72 ± 0.08 | 23.51 ± 0.11 | 0.196 |
DM duration (mean ± SE, years) | 0 | 3.51 ± 0.29 | 14.61 ± 0.57 | <0.001 |
HbA1C (mean ± SE, %) | N/A | 6.90 ± 0.10 | 7.04 ± 0.12 | 0.397 |
CMT (mean ± SE, μm) | 250.22 ± 1.99 | 246.04 ± 1.93 | 248.49 ± 2.44 | 0.317 |
pRNFL thickness (mean ± SE, μm) | 96.71 ± 0.88 | 94.82 ± 1.07 | 92.49 ± 1.34 | 0.032 |
Control | DM Group 1 | DM Group 2 | p-Value | |
---|---|---|---|---|
Average | 84.58 ± 0.89 | 83.49 ± 0.70 | 79.04 ± 0.96 | <0.001 |
Minimum | 79.61 ± 0.91 | 80.03 ± 0.94 | 73.39 ± 1.70 | <0.001 |
Sector | ||||
Superior | 83.89 ± 0.82 | 84.39 ± 0.71 | 78.98 ± 1.11 | <0.001 |
Superotemporal | 82.13 ± 1.03 | 81.91 ± 0.78 | 78.81 ± 1.03 | 0.014 |
Inferotemporal | 82.89 ± 0.75 | 83.05 ± 0.78 | 79.54 ± 0.99 | 0.008 |
Inferior | 80.88 ± 0.76 | 81.13 ± 0.73 | 77.26 ± 0.88 | 0.001 |
Inferonasal | 83.27 ± 0.79 | 83.61 ± 0.79 | 79.07 ± 1.08 | 0.001 |
Superonasal | 85.73 ± 0.82 | 86.12 ± 0.82 | 80.46 ± 1.45 | <0.001 |
Control | DM Group 1 | DM Group 2 | p-Value | |
---|---|---|---|---|
Full area | 20.32 ± 0.15 | 19.46 ± 0.17 | 18.46 ± 0.23 | <0.001 |
Inner area | 21.70 ± 0.14 | 20.77 ± 0.17 | 19.78 ± 0.24 | <0.001 |
Central area | 9.41 ± 0.28 | 9.34 ± 0.30 | 8.27 ± 0.31 | 0.027 |
Sector | ||||
Superior | 21.58 ± 0.19 | 20.65 ± 0.22 | 19.72 ± 0.30 | <0.001 |
Temporal | 21.62 ± 0.14 | 20.76 ± 0.19 | 20.05 ± 0.23 | <0.001 |
Inferior | 21.74 ± 0.15 | 20.75 ± 0.22 | 19.89 ± 0.30 | <0.001 |
Nasal | 21.83 ± 0.22 | 20.91 ± 0.21 | 19.49 ± 0.39 | <0.001 |
Univariate | Multivariate | |||
---|---|---|---|---|
B (95% CI) | p-Values | B (95% CI) | p-Values | |
Age | −0.01 (−0.03–0.03) | 0.997 | ||
Sex | −0.33 (−0.77–0.11) | 0.138 | ||
DM duration | −0.07 (−0.11–−0.03) | 0.002 | −0.05 (−0.09–−0.01) | 0.037 |
BCVA | −5.13 (−9.69–−0.57) | 0.028 | −5.39 (−9.62–−1.15) | 0.013 |
SE | 0.02 (−0.19–0.23) | 0.825 | ||
IOP | 0.04 (−0.06–0.14) | 0.442 | ||
Axial length | −0.03 (−0.39–0.33) | 0.866 | ||
HbA1C | −0.27 (−0.56–0.02) | 0.069 | −0.06 (−0.35–0.23) | 0.666 |
CMT | 0.01 (−0.02–0.02) | 0.989 | ||
pRNFL | 0.02 (−0.01–0.05) | 0.096 | −0.02 (−0.05–0.01) | 0.226 |
GC-IPL | 0.08 (0.05–0.12) | <0.001 | 0.07 (0.04–0.11) | <0.001 |
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Lee, M.-W.; Lee, W.-H.; Ryu, C.-K.; Kim, T.-Y.; Lim, H.-B.; Lee, Y.-H.; Kim, J.-Y. Effects of Prolonged Type 2 Diabetes on the Inner Retinal Layer and Macular Microvasculature: An Optical Coherence Tomography Angiography Study. J. Clin. Med. 2020, 9, 1849. https://doi.org/10.3390/jcm9061849
Lee M-W, Lee W-H, Ryu C-K, Kim T-Y, Lim H-B, Lee Y-H, Kim J-Y. Effects of Prolonged Type 2 Diabetes on the Inner Retinal Layer and Macular Microvasculature: An Optical Coherence Tomography Angiography Study. Journal of Clinical Medicine. 2020; 9(6):1849. https://doi.org/10.3390/jcm9061849
Chicago/Turabian StyleLee, Min-Woo, Woo-Hyuk Lee, Cheon-Kuk Ryu, Tae-Yeon Kim, Hyung-Bin Lim, Young-Hoon Lee, and Jung-Yeul Kim. 2020. "Effects of Prolonged Type 2 Diabetes on the Inner Retinal Layer and Macular Microvasculature: An Optical Coherence Tomography Angiography Study" Journal of Clinical Medicine 9, no. 6: 1849. https://doi.org/10.3390/jcm9061849
APA StyleLee, M. -W., Lee, W. -H., Ryu, C. -K., Kim, T. -Y., Lim, H. -B., Lee, Y. -H., & Kim, J. -Y. (2020). Effects of Prolonged Type 2 Diabetes on the Inner Retinal Layer and Macular Microvasculature: An Optical Coherence Tomography Angiography Study. Journal of Clinical Medicine, 9(6), 1849. https://doi.org/10.3390/jcm9061849