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Volume 12
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10.3390/agriculture12070947
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Review

The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation

by
Qinyue Lu
1,2,†,
Weicheng Zong
3,†,
Mingyixing Zhang
1,2,
Zhi Chen
1,2,* and
Zhangping Yang
1,2
1
College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
2
Joint International Research Laboratory of Agriculture & Agri-Product Safety, Ministry of Education, Yangzhou University, Yangzhou 225009, China
3
College of Veterinary Medcine, Yangzhou University, Yangzhou 225009, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Agriculture 2022, 12(7), 947; https://doi.org/10.3390/agriculture12070947
Submission received: 21 May 2022 / Revised: 21 June 2022 / Accepted: 29 June 2022 / Published: 30 June 2022
(This article belongs to the Special Issue Breeding, Genetics and Safety Production of Dairy Cattle)
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Abstract

Beta-oxidation(β-oxidation) is an important metabolic process involving multiple steps by which fatty acid molecules are broken down to produce energy. The very long-chain fatty acids (VLCFAs), a type of fatty acid (FA), are usually highly toxic when free in vivo, and their oxidative metabolism depends on the peroxisomal β-oxidation. For a long time, although β-oxidation takes place in both mitochondria and peroxisomes, most studies have been keen to explore the mechanism of β-oxidation in mitochondria while ignoring the importance of peroxisomal β-oxidation. However, current studies indicate that it is hard to provide effective treatment for diseases caused by the disorder of peroxisomal β-oxidation, such as X-ALD, SCOX deficiency, and D-BP deficiency; thus, actions should be taken to solve this problem. Based on existing research results, this review will summarize the importance of peroxisomal β-oxidation and help further learning.
Keywords: peroxisome; very long-chain fatty acids; beta-oxidation peroxisome; very long-chain fatty acids; beta-oxidation

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MDPI and ACS Style

Lu, Q.; Zong, W.; Zhang, M.; Chen, Z.; Yang, Z. The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation. Agriculture 2022, 12, 947. https://doi.org/10.3390/agriculture12070947

AMA Style

Lu Q, Zong W, Zhang M, Chen Z, Yang Z. The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation. Agriculture. 2022; 12(7):947. https://doi.org/10.3390/agriculture12070947

Chicago/Turabian Style

Lu, Qinyue, Weicheng Zong, Mingyixing Zhang, Zhi Chen, and Zhangping Yang. 2022. "The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation" Agriculture 12, no. 7: 947. https://doi.org/10.3390/agriculture12070947

APA Style

Lu, Q., Zong, W., Zhang, M., Chen, Z., & Yang, Z. (2022). The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation. Agriculture, 12(7), 947. https://doi.org/10.3390/agriculture12070947

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