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Article

Bioprinted 3D Bionic Scaffolds with Pancreatic Islets as a New Therapy for Type 1 Diabetes—Analysis of the Results of Preclinical Studies on a Mouse Model

by
Marta Klak
1,2,
Michał Wszoła
1,2,*,
Andrzej Berman
1,2,
Anna Filip
1,
Anna Kosowska
3,
Joanna Olkowska-Truchanowicz
4,
Michał Rachalewski
1,
Grzegorz Tymicki
1,
Tomasz Bryniarski
1,
Marta Kołodziejska
1,
Tomasz Dobrzański
2,
Dominika Ujazdowska
1,
Jarosław Wejman
5,
Izabela Uhrynowska-Tyszkiewicz
4 and
Artur Kamiński
4
1
Foundation of Research and Science Development, 01-793 Warsaw, Poland
2
Polbionica Sp. z o.o., 01-793 Warsaw, Poland
3
Chair and Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warsaw, Poland
4
Department of Transplantology and Central Tissue Bank, Medical University of Warsaw, 02-004 Warsaw, Poland
5
Center for Pathomorphological Diagnostics Sp. z o.o., 01-496 Warsaw, Poland
*
Author to whom correspondence should be addressed.
J. Funct. Biomater. 2023, 14(7), 371; https://doi.org/10.3390/jfb14070371
Submission received: 9 June 2023 / Revised: 7 July 2023 / Accepted: 8 July 2023 / Published: 14 July 2023
(This article belongs to the Section Biomaterials for Tissue Engineering and Regenerative Medicine)
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Abstract

Recently, tissue engineering, including 3D bioprinting of the pancreas, has acquired clinical significance and has become an outstanding potential method of customized treatment for type 1 diabetes mellitus. The study aimed to evaluate the function of 3D-bioprinted pancreatic petals with pancreatic islets in the murine model. A total of 60 NOD-SCID (Nonobese diabetic/severe combined immunodeficiency) mice were used in the study and divided into three groups: control group; IsletTx (porcine islets transplanted under the renal capsule); and 3D bioprint (3D-bioprinted pancreatic petals with islets transplanted under the skin, on dorsal muscles). Glucose, C-peptide concentrations, and histological analyses were performed. In the obtained results, significantly lower mean fasting glucose levels (mg/dL) were observed both in a 3D-bioprint group and in a group with islets transplanted under the renal capsule when compared with untreated animals. Differences were observed in all control points: 7th, 14th, and 28th days post-transplantation (129, 119, 118 vs. 140, 139, 140; p < 0.001). Glucose levels were lower on the 14th and 28th days in a group with bioprinted petals compared to the group with islets transplanted under the renal capsule. Immunohistochemical staining indicated the presence of secreted insulin-living pancreatic islets and neovascularization within 3D-bioprinted pancreatic petals after transplantation. In conclusion, bioprinted bionic petals significantly lowered plasma glucose concentration in studied model species.
Keywords: diabetes; pancreas islets; 3D bioprinting; glucose; xenotransplantation; bionic scaffold diabetes; pancreas islets; 3D bioprinting; glucose; xenotransplantation; bionic scaffold

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MDPI and ACS Style

Klak, M.; Wszoła, M.; Berman, A.; Filip, A.; Kosowska, A.; Olkowska-Truchanowicz, J.; Rachalewski, M.; Tymicki, G.; Bryniarski, T.; Kołodziejska, M.; et al. Bioprinted 3D Bionic Scaffolds with Pancreatic Islets as a New Therapy for Type 1 Diabetes—Analysis of the Results of Preclinical Studies on a Mouse Model. J. Funct. Biomater. 2023, 14, 371. https://doi.org/10.3390/jfb14070371

AMA Style

Klak M, Wszoła M, Berman A, Filip A, Kosowska A, Olkowska-Truchanowicz J, Rachalewski M, Tymicki G, Bryniarski T, Kołodziejska M, et al. Bioprinted 3D Bionic Scaffolds with Pancreatic Islets as a New Therapy for Type 1 Diabetes—Analysis of the Results of Preclinical Studies on a Mouse Model. Journal of Functional Biomaterials. 2023; 14(7):371. https://doi.org/10.3390/jfb14070371

Chicago/Turabian Style

Klak, Marta, Michał Wszoła, Andrzej Berman, Anna Filip, Anna Kosowska, Joanna Olkowska-Truchanowicz, Michał Rachalewski, Grzegorz Tymicki, Tomasz Bryniarski, Marta Kołodziejska, and et al. 2023. "Bioprinted 3D Bionic Scaffolds with Pancreatic Islets as a New Therapy for Type 1 Diabetes—Analysis of the Results of Preclinical Studies on a Mouse Model" Journal of Functional Biomaterials 14, no. 7: 371. https://doi.org/10.3390/jfb14070371

APA Style

Klak, M., Wszoła, M., Berman, A., Filip, A., Kosowska, A., Olkowska-Truchanowicz, J., Rachalewski, M., Tymicki, G., Bryniarski, T., Kołodziejska, M., Dobrzański, T., Ujazdowska, D., Wejman, J., Uhrynowska-Tyszkiewicz, I., & Kamiński, A. (2023). Bioprinted 3D Bionic Scaffolds with Pancreatic Islets as a New Therapy for Type 1 Diabetes—Analysis of the Results of Preclinical Studies on a Mouse Model. Journal of Functional Biomaterials, 14(7), 371. https://doi.org/10.3390/jfb14070371

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