The Effectiveness of the Addition of Platelet-Rich Fibrin to Bovine Xenografts in Sinus and Bone Ridge Augmentation: A Systematic Review
Abstract
:1. Introduction
2. Materials and Methods
2.1. Search Strategy
2.2. Screening and Study Selection
2.3. Article Selection and Data Extraction
2.4. Quality Assessment
3. Results
3.1. Study Selection
3.2. Description of Included Studies
3.3. Analysis of the Risk of Bias
4. Discussion
5. Conclusions
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Pubmed (filters applied: Randomized Control Trial, Clinical trials) | (“Bio-Oss” [Mesh] OR deproteinized bovine bone mineral OR bovine-derived xenograft OR bovine bone OR xenograft OR bone grafts OR bone substitutes) AND (“Platelet-Rich Fibrin” [Mesh] OR fibrin, platelet-rich OR platelet rich fibrin OR leukocyte- and platelet-rich fibrin OR leukocyte and platelet rich fibrin OR l-PRF OR PRF) AND (“Alveolar Ridge Augmentation” [Mesh] OR augmentation, alveolar ridge OR ridge augmentation, alveolar OR mandibular ridge augmentation OR maxillary ridge augmentation OR “Sinus Floor Augmentation” [Mesh] OR augmentation, sinus floor OR maxillary sinus augmentation OR sinus lifting OR maxillary sinus lift OR horizontal ridge augmentation OR vertical ridge augmentation) |
Cochrane library (All text) | Bio-Oss OR deproteinized bovine bone mineral OR bovine-derived xenograft OR bovine bone OR xenograft OR bone grafts OR bone substitutes AND Platelet-Rich Fibrin OR fibrin, platelet rich OR platelet rich fibrin OR leukocyte and platelet rich fibrin OR leukocyte and platelet rich fibrin OR l-PRF OR PRF AND Alveolar Ridge Augmentation OR augmentation, alveolar ridge OR ridge augmentation, alveolar OR mandibular ridge augmentation OR maxillary ridge augmentation OR Sinus Floor Augmentation OR augmentation, sinus floor OR maxillary sinus augmentation OR sinus lifting OR maxillary sinus lift OR horizontal ridge augmentation OR vertical ridge augmentation |
Web of Sciences (All Fields; Articles) | Bio-Oss AND Platelet-Rich Fibrin AND Alveolar Ridge Augmentation OR Sinus Floor Augmentation AND Human Clinical Trials |
Author, Year of Publication, Country | Study Design | Nb. of Patients (Mean Age ± SD | Study Group | Nb. of Implants per Group (n) (Implant References) | Follow-up | X-ray Outcomes | Histomorphometric/Histological Outcomes | Findings |
---|---|---|---|---|---|---|---|---|
Harlos et al., 2022, Brazil [33] | RCT | 36 (53.8 ± 4.6) | G1 (n = 12): DBBM (Bio Oss, Geistlich Pharma AG, Wolhusen, Switzerland) + autogenous bone G2 (GT) (n = 12): DBBM + L-PRF centrifuged at 2700 rpm for 12 min G3 (GC) (n = 12): DBBM alone Patients were treated for one maxillary sinus atrophy (sinus lift) | G1 (n = 24) G2 (n = 24) G3 (n = 24) Implants were placed 8 months after sinus lift (NS) | Clinical and radiographical follow-up at 8 months | (NS) | Histomorphometric evaluation was performed 8 months after sinus lift G1 NFB (39.97 ± 2.50%) RG (31.15 ± 3.39%) PST (28.88 ± 4.88%) G2 NFB (28.60 ± 2.32%) RG (25.41 ± 1.71%) PST (45.99 ± 2.71%) G3 NFB (26.81 ± 1.83%) RG (28.84 ± 3.55%) PST (44.36 ± 2.67%) | A statistically significant difference was found between GT and GCs in RG (p < 0.0001) No statistically significant difference was found between GT and GCs in NFB (p > 0.05) and PST (p > 0.5) |
Işık et al., 2021, Turkey [35] | RCT | 40 (49.99 ± 7.73) | GT (n = 22): DBBM (Bio Oss, Geistlich Pharma AG, Wolhusen, Switzerland) + L-PRF centrifuged at 700 rpm for 3 min + resorbable membrane (Bio-GideTM, Geistlich Pharma AG, Wolhusen, Switzerland) GC (n = 22): DBBM + resorbable membrane Patient were treated for guided GBR in bone deficiency in the mandibular posterior region | GT (n = 50) GC (n = 48) Implants were placed simultaneously with the GBR procedure. Implant diameter was between 3.8 and 4.2 Ø and length was between 10 and 11 mm | Clinical and radiographical follow-up immediately after surgery and at 6 months, 1 year, and 2 years | CBCT after 6 months GT RBW (4.25 ± 0.26 mm) AT measured coronally (1.63 ± 0.21 mm) AT measured medially (2.59 ± 0.34 mm) AT measured apically (3.11 ± 0.36 mm) GC RBW (4.33 ± 0.28 mm) AT measured coronally (1.34 ± 0.14 mm) AT measured medially (2.49 ± 0.24 mm) AT measured apically (2.97 ± 0.24 mm) | (NS) | No statistically significant difference was found between groups in X-ray parameters before RGB in RBW (p = 0.512). A statically significant difference was observed between GT and GC in AT measured coronally, medially, and apically (p < 0.001, p = 0.007, and p = 0.036, respectively) |
Irdem et al., 2021, Turkey [34] | RCT (split-mouth) | 7 (50.57 ± 11.73) | GT (n = 7): DBBM (Bio Oss, Geistlich Pharma AG, Wolhusen, Switzerland) + L-PRF prepared from 9 mL blood sample tubes centrifuged at 2300 rpm for 15 min GC (n = 7): DBBM alone Patients were treated for bilateral maxillary sinus atrophy (sinus lift) | GT (n = 7) GC (n = 7) Implants were placed 4 months after sinus lift (NS) | Clinical and radiographical follow-up at 1 week, 1 month, 4 months, and 2 years | Panoramic X-rays after 4 months GT: RBH (3.77 mm) GC: RBH (3.88 mm) | Histomorphometric evaluation was performed 4 months after sinus lift GT: NFB (45.95%), MB (14.40%), RG (10.32%), FTR (29.31%), osteocalcin score (2.81 ± 0.36) GC: NFB (39.49%), MB (15.66%), RG (15.62%), FTR (28.59%), osteocalcin score (2.70 ± 0.39) | No statistically significant difference was found between groups in histomorphometric and X-ray parameters after sinus augmentation (p > 0.05). No problems were observed in any of the implants during the 2 year follow-up period. |
Picotano et al., 2019, Brazil [37] | RCT (split-mouth) | 12 (54.17 ± 6.95) | GT (n = 6): DBBM (Bio Oss, Geistlich Pharma AG, Wolhusen, Switzerland) + L-PRF centrifuged at 3000 rpm for 10 min + resorbable membrane (Bio-GideTM, Geistlich Pharma AG, Wolhusen, Switzerland) GC (n = 6): DBBM + resorbable membrane Patients were treated for bilateral maxillary sinus atrophy (sinus lift) | GT (n = 19) GC (n = 19) Implants were placed 4 months after the sinus lift for the GT and 8 months after the sinus lift for the GC (NS) | Clinical and radiographical follow-up at 1 week and 4 months in the GT and 8 months in the GC | CBCT GT after 4 months MGV 1.10 ± 0.25 cm3 GC after 8 months MGV 0.91 ± 0.35 cm3 | Histomorphometric evaluation was performed 4 months after sinus lift GT 4 months: NFB (44.58 ± 0.73%), RG (3.59 ± 4.22%), PST (26.60 ± 11.13%) GC 8 months: NFB (30.02 ± 8.42%), RG (13.75 ± 9.99%), PST (30.64 ± 12.46%) | No statistically significant difference was found in histomorphometric parameters after sinus augmentation in the GT (4 months) and GC (8 months) PST (p = 0.376) Statistically significant differences were found in histomorphometric parameters after sinus augmentation in the GT (4 months) and GC (8 months) NFB (p = 0.0087) RG (p = 0.011) No statistically significant difference was found in mean graft volume in GT and GC |
Nizam et al., 2018, Turkey [36] | RCT (split-mouth) | 13 (49.92 ± 10.37) | GT (n = 13): DBBM (Bio Oss, Geistlich Pharma AG, Wolhusen, Switzerland) + L-PRF centrifuged at 4000 rpm for 12 min GC (n = 13): DBBM alone Patients were treated for bilateral maxillary sinus atrophy (sinus lift) | GT (n = 30) GC (n = 28) Implants were placed 6 months after sinus lift Bone level implants [Institut Straumann AG, Basel, Switzerland (test: 11 and control: 11) and Zimmer TSV Implant System, Carlsbad, CA, USA (test: 19 and control: 17)] with diameters between 4.1 and 6.0 Ø and lengths between 10 and 13 mm | Clinical and radiographical follow-up at 6 months and 12 months | Panoramic X-rays after 6 months GT: RBH (2.45 ± 0.79 mm), ABH (13.60 ± 1.09 mm) GC: RBH (2.53 ± 0.61 mm), ABH (13.53 ± 1.20 mm) | Histomorphometric evaluation was performed 6 months after sinus lift GT: NFB (21.38 ± 8.78%), RG (25.95 ± 9.54%) RG in contact with NFB (47.33 ± 12.33%), PST (test; 52.67 ± 12.53%) GC: NFB (21.25 ± 5.59%), RG (32.79 ± 5.89%) RG in contact with NFB (54.04 ± 8.36%), PST (45.96 ± 8.36%) | No statistically significant difference was found between both groups in histomorphometric parameters after sinus augmentation: NFB (p = 0.96), RG (p = 0.06), RG in contact with NFB (p = 0.16) No statistically significant difference was found between groups in X-ray parameters after sinus augmentation No problems were observed in any of the implants during the 12 month follow-up period |
Tatullo et al., 2012, Italy [38] | RCT (split mouth n = 12) | 60 (55.15 ± NS) | GT (n = 36): DBBM (Bio Oss, Geistlich Pharma AG, Wolhusen, Switzerland) + PRF centrifuged 3000 rpm for 10 min GC (n = 24): DBBM alone 48 patients were treated for one maxillary sinus atrophy (sinus lift) and 12 were treated for bilateral maxillary sinus atrophy | Total (n = 120) GT = NS GC = NS | Radiographical follow-up at 6 months after implantation | Histomorphometric evaluation was performed 106 days (T1), 120 days (T2) and 150 (T3) days after sinus lift GT: TB (T1) 22.79% (T2) 26.15% (T3) 37.06% PST (T1) 70.2% (T2) 70.01 (T3) 61.41% GC: TB (T1) 26.44% (T2) 28.7% (T3) 38.97% PST (T1) 68.44% (T2) 68.18% (T3) 58.15% | No statistical analysis was performed | |
Zhang et al., 2012, China [39] | RCT | 10 (44.85 ± NS) | GT (n = 5): DBBM (Bio Oss, Geistlich Pharma AG, Wolhusen, Switzerland) + PRF prepared at 3000 rpm for 13 min GC (n = 5): DBBM alone All patients were treated for unilateral maxillary sinus atrophy (sinus lift) except one patient treated for bilateral maxillary sinus atrophy in the test group | GT (n = 6) GC (n = 5) Implants were placed 6 months after the sinus lift (Replace Nobel Biocare) | Clinical follow-up at 1 week, 1 month, 3 months, and 6 months Radiographical follow-up immediately after the intervention and at 3 months and 6 months | Panoramic X-rays after 6 months (NS) | Histomorphometric evaluation was performed 6 months after sinus lift GT: NFB (18.35 ± 5.62%) RG (19.16 ± 6.89%) RG in contact with NFB (21.45 ± 14.57%) GC: NFB (12.95 ± 5.33%) RG (28.54 ± 12.01%) RG in contact with NFB (18.57 ± 5.39%) | No statistically significant difference was found between groups in histomorphometric parameters after sinus augmentation: NFB (p = 0.138), RG (p = 0.141), RG in contact with NFB (p > 0.05) |
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Idiri, K.; Bandiaky, O.; Soueidan, A.; Verner, C.; Renard, E.; Struillou, X. The Effectiveness of the Addition of Platelet-Rich Fibrin to Bovine Xenografts in Sinus and Bone Ridge Augmentation: A Systematic Review. J. Funct. Biomater. 2023, 14, 389. https://doi.org/10.3390/jfb14070389
Idiri K, Bandiaky O, Soueidan A, Verner C, Renard E, Struillou X. The Effectiveness of the Addition of Platelet-Rich Fibrin to Bovine Xenografts in Sinus and Bone Ridge Augmentation: A Systematic Review. Journal of Functional Biomaterials. 2023; 14(7):389. https://doi.org/10.3390/jfb14070389
Chicago/Turabian StyleIdiri, Katia, Octave Bandiaky, Assem Soueidan, Christian Verner, Emmanuelle Renard, and Xavier Struillou. 2023. "The Effectiveness of the Addition of Platelet-Rich Fibrin to Bovine Xenografts in Sinus and Bone Ridge Augmentation: A Systematic Review" Journal of Functional Biomaterials 14, no. 7: 389. https://doi.org/10.3390/jfb14070389