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Nanomaterials
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Article

Internalization of Metal–Organic Framework Nanoparticles in Human Vascular Cells: Implications for Cardiovascular Disease Therapy

by
Dana E. Al-Ansari
1,†,
Nura A. Mohamed
1,†,
Isra Marei
2,3,
Atef Zekri
4,
Yu Kameno
5,
Robert P. Davies
5,
Paul D. Lickiss
5,
Md Mizanur Rahman
1 and
Haissam Abou-Saleh
1,6,*
1
Department of Biological and Environmental Sciences, Qatar University, Doha 2713, Qatar
2
Department of Pharmacology, Weill Cornell Medicine-Qatar, Doha 24811, Qatar
3
Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK
4
Qatar Energy and Environment Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha 34110, Qatar
5
Department of Chemistry, Imperial College, London, White City Campus, 80 Wood Lane, London W12 0BZ, UK
6
Biomedical Research Center, QU Health, Qatar University, Doha 2713, Qatar
*
Author to whom correspondence should be addressed.
†
Equal contribution.
Nanomaterials 2020, 10(6), 1028; https://doi.org/10.3390/nano10061028
Submission received: 26 April 2020 / Revised: 17 May 2020 / Accepted: 19 May 2020 / Published: 27 May 2020
(This article belongs to the Special Issue Nanomedicine in Drug Delivery)
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Abstract

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Alteration of endothelial cells and the underlying vasculature plays a central role in the pathogenesis of various CVDs. The application of nanoscale materials such as nanoparticles in biomedicine has opened new horizons in the treatment of CVDs. We have previously shown that the iron metal–organic framework nanoparticle, Materials Institut Lavoisier-89 (nanoMIL-89) represents a viable vehicle for future drug delivery of pulmonary arterial hypertension. In this study, we have assessed the cellular uptake of nanoMIL-89 in pulmonary artery endothelial and smooth muscle cells using microscopy imaging techniques. We also tested the cellular responses to nanoMIL-89 using molecular and cellular assays. Microscopic images showed cellular internalization of nanoMIL-89, packaging into endocytic vesicles, and passing to daughter cells during mitosis. Moreover, nanoMIL-89 showed anti-inflammatory activity without any significant cytotoxicity. Our results indicate that nanoMIL-89 formulation may offer promising therapeutic opportunities and set forth a new prototype for drug delivery not only in CVDs, but also for other diseases yet incurable, such as diabetes and cancer.
Keywords: nanomedicine; cardiovascular diseases; metal–organic framework nanoparticles; MIL-89; endothelial cells; smooth muscle cells nanomedicine; cardiovascular diseases; metal–organic framework nanoparticles; MIL-89; endothelial cells; smooth muscle cells

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MDPI and ACS Style

Al-Ansari, D.E.; Mohamed, N.A.; Marei, I.; Zekri, A.; Kameno, Y.; Davies, R.P.; Lickiss, P.D.; Rahman, M.M.; Abou-Saleh, H. Internalization of Metal–Organic Framework Nanoparticles in Human Vascular Cells: Implications for Cardiovascular Disease Therapy. Nanomaterials 2020, 10, 1028. https://doi.org/10.3390/nano10061028

AMA Style

Al-Ansari DE, Mohamed NA, Marei I, Zekri A, Kameno Y, Davies RP, Lickiss PD, Rahman MM, Abou-Saleh H. Internalization of Metal–Organic Framework Nanoparticles in Human Vascular Cells: Implications for Cardiovascular Disease Therapy. Nanomaterials. 2020; 10(6):1028. https://doi.org/10.3390/nano10061028

Chicago/Turabian Style

Al-Ansari, Dana E., Nura A. Mohamed, Isra Marei, Atef Zekri, Yu Kameno, Robert P. Davies, Paul D. Lickiss, Md Mizanur Rahman, and Haissam Abou-Saleh. 2020. "Internalization of Metal–Organic Framework Nanoparticles in Human Vascular Cells: Implications for Cardiovascular Disease Therapy" Nanomaterials 10, no. 6: 1028. https://doi.org/10.3390/nano10061028

APA Style

Al-Ansari, D. E., Mohamed, N. A., Marei, I., Zekri, A., Kameno, Y., Davies, R. P., Lickiss, P. D., Rahman, M. M., & Abou-Saleh, H. (2020). Internalization of Metal–Organic Framework Nanoparticles in Human Vascular Cells: Implications for Cardiovascular Disease Therapy. Nanomaterials, 10(6), 1028. https://doi.org/10.3390/nano10061028

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