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Nanomaterials
Volume 12
Issue 6
10.3390/nano12060990
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Article
Peer-Review Record

Antiviral Properties of Silver Nanoparticles against SARS-CoV-2: Effects of Surface Coating and Particle Size

Nanomaterials 2022, 12(6), 990; https://doi.org/10.3390/nano12060990
by Qinghao He 1,†, Jing Lu 2,†, Nian Liu 3,†, Wenqing Lu 4, Yu Li 1, Chao Shang 2,*, Xiao Li 2,*, Ligang Hu 1,3,5,* and Guibin Jiang 1,3
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Nanomaterials 2022, 12(6), 990; https://doi.org/10.3390/nano12060990
Submission received: 2 February 2022 / Revised: 12 March 2022 / Accepted: 14 March 2022 / Published: 17 March 2022
(This article belongs to the Section Biology and Medicines)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

I consider that the manuscript  Antiviral properties of silver nanoparticles against SARS-CoV-2: Effects of surface coating and particle size  should be consider for publication in Nanomaterials MDPI.

I have suggested some changes in the manuscript, which can be found in the attachment word file.

Questions:

  • The Transmission Electron Microscopy of AgNPs has been included in the manuscript. Is it possible to include some reference or micrography to show the size and shape of the SARS-CoV-2 or more important the effect of nanoparticles?
  • The effect of the particle size of AgNPs has been described in this work. What would happen with the shape of the NPs, would be the same with nanocubes, nanorods, nanostars, etc.?

Best Regards!!!

Comments for author File: Comments.pdf

Author Response

Please see responses in attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

  1. The inroduction is not uptodate.
  2. Fig. 5 D please change the y-axis range in apoptosis curve. 
  3. On my opinion, the application of your nanoparticles as external antimicrobial agent has no correlation with exams on infected cells.    

Author Response

Please see responses in attachment

Author Response File: Author Response.pdf

Reviewer 3 Report

  1. Give the particle and zeta potential image of the formulation.
  2. what is the rationale of experiments.
  3. how much is the IC 50 value.
  4. Add some research article related to the work in introduction section.
  5. Discusion part is poor Need to be revised and elaborated.

Author Response

Please see responses in attachment

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

On, my opinion there is no relevance between the experiments (infected cells) and the research aim (usage of AgNo3 as surface antimicrobal/nasal spray). 

Author Response

see attachment

Author Response File: Author Response.docx

Reviewer 3 Report

accept

Author Response

Thanks for your favorable recommendation.

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