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Nanomaterials
Volume 12
Issue 7
10.3390/nano12071195
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Review
Peer-Review Record

Current Methods in the Study of Nanomaterials for Bone Regeneration

Nanomaterials 2022, 12(7), 1195; https://doi.org/10.3390/nano12071195
by Manabu Tanaka 1,*,†, Makoto Izumiya 2,3,†, Hisao Haniu 2,3,4,*, Katsuya Ueda 2,3, Chuang Ma 2,3, Koki Ueshiba 2,4, Hirokazu Ideta 3,5, Atsushi Sobajima 5,6, Shigeharu Uchiyama 1, Jun Takahashi 5 and Naoto Saito 2
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Nanomaterials 2022, 12(7), 1195; https://doi.org/10.3390/nano12071195
Submission received: 17 February 2022 / Revised: 21 March 2022 / Accepted: 30 March 2022 / Published: 2 April 2022
(This article belongs to the Special Issue Application and Evaluation Method of Nanomaterial in Bone Regenerative Medicine)

Round 1

Reviewer 1 Report

  1. Authors should provide a schematic diagram of autophagy-derived regulation on the differentiation and function of osteoclast, osteoblast, and osteoimmunology
  2. Authors should provide tables and diagrams of the main inorganic nanomaterials used for bone tissue regeneration
  3. Table for the advantages and drawbacks of inorganic nanomaterials.
  4. Explain bone fracture repair processes
  5. Should include an explanation about smart nanomaterials
  6. Include other nanomaterials like polymeric composites, nanotubes, nanofibers etc.
  7. Should explain the chemical and physical properties of nanomaterials
  8. Provide a table for engineering nanomaterials for bone regeneration
  9. Should include challenges and opportunities
  10. Review article should contain at least 3-4 figures and tables with a comparison of previously reported data

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

This reviews deals with current methods in study of nanomaterials for bone regeneration. This is a very interesting topic and should be explored. 

there are several issues with the current form of this paper:

1) it is not clear why this review paper is unique and offer different point of views. The authors should have made it very clear in the text. 

2. the paper reads like a protocol, with very detailed information about cell types and cell culture media components. I do not see the need for this information. 

3. The paper discussed more on the scaffold than bone regeneration. I am not sure if this focus shift is wise if the title is "study of nanomaterials for bone regeneration". 

English is easy to read and helps to follow the text. 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

Accept in present form

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