This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Open AccessArticle
A Biocompatible, Highly Sensitive, and Non-Enzymatic Glucose Electrochemical Sensor Based on a Copper-Cysteamine (Cu-Cy)/Chitosan-Modified Electrode
by
Huan Chen
Huan Chen 1,
Tingting Gu
Tingting Gu
Prof. Tingting Gu is a professor at the School of Chemical Engineering, University of Science and in [...]
Prof. Tingting Gu is a professor at the School of Chemical Engineering, University of Science and Technology Liaoning. She graduated from Shenyang Pharmaceutical University in 1996 with a bachelor’s degree, a master’s degree from Saitama Institute of Technology in Japan in 2003, and a doctoral degree from Saitama Institute of Technology in Japan in 2006. She is a Thousand-level Talent of Liaoning Province’s Hundred Thousand Talents Project, a member of the Liaoning Provincial Teaching Team for “Physical Chemistry”, and the Director of the National First-Class Undergraduate Course “Physical Chemistry”. She is mainly engaged in the research of electrochemical sensors and fuel cells. Her main research directions are research on new electrochemical DNA and enzyme biosensors, research on electrochemical sensors for environmental pollutants, and research on new fuel cells.
1,*,
Longyang Lv
Longyang Lv 1,
Xing Chen
Xing Chen 1,
Qifeng Lu
Qifeng Lu
Dr. Qifeng Lu is an Associate Professor at the School of CHIPS, Xian Jiantong-Liverpool University. [...]
Dr. Qifeng Lu is an Associate Professor at the School of CHIPS, Xian Jiantong-Liverpool University. He received his PhD degree in 2018 from the University of Liverpool. In 2017–2018, Qifeng had a one-year industrial research experience in a leading LED company, Focus Lightings Tech Co., Ltd. He was in the RD department and was responsible for the luminous efficiency improvement of LED chips. From 2018 to 2021, Qifeng joined the Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, and worked as a postdoctoral fellow. He has won the 2023 MINE Young Scientist Award and the 2023 All Round Academic Excellence Award of XJTLU Entrepreneur College (Taicang). His research interests include neuromorphic devices and biosensors.
2,
Amer Kotb
Amer Kotb
Dr. Amer Kotb is an Associate Professor at the School of CHIPS, Xian Jiaotong-Liverpool University. [...]
Dr. Amer Kotb is an Associate Professor at the School of CHIPS, Xian Jiaotong-Liverpool University. He received his MSc and PhD in electronics in 2006 and 2012, respectively. He was a PhD researcher in the Department of Physics at the University of Connecticut in the USA. He is an associate professor in the School of Chips at the XJTLU. He is also a professor of electronics at the University of Fayoum in Egypt. He worked as an associate professor at the Chinese Academy of Sciences from 2017 to 2023. He also worked as an assistant professor and vice head of the Physics Department at Northern Border University in Saudi Arabia from 2012 to 2015. He has won the Talent Young Scientist Program (TYSP) twice (i.e., in 2019 and 2020) and the Chinese Academy of Sciences President’s International Fellowship Initiative (PIFI) three times (i.e., in 2019, 2022, and 2023) supported by the Chinese Government. He was ranked as one of the world’s top 2% scientists by Stafford University for 2020, 2021, 2022, and 2023. His current research activities include investigating and simulating all-optical logic devices using different optical waveguides.
2 and
Wei Chen
Wei Chen
Dr. Wei Chen is the dean of the School of CHIPS at Xi’an Jiaotong-Liverpool University. He his his [...]
Dr. Wei Chen is the dean of the School of CHIPS at Xi’an Jiaotong-Liverpool University. He received his bachelor’s from Jilin University, his master’s at Central South University, and his Ph.D. in chemistry at Peking University. He held the esteemed position of University Distinguished Professor within the Physics department at the University of Texas at Arlington (UTA), Texas, USA. His groundbreaking scientific endeavors have gained widespread recognition, notably drawing attention from CBS in the USA. His eminence within the field was further solidified by his election as a Fellow of the International Association of Advanced Materials and a Fellow of the Royal Society of Chemistry (UK) in 2021. In 2022, he received the IMMA Scientist Award for his exceptional contributions to nanotechnology. His remarkable achievements were acknowledged by his election as a Fellow of the US National Academy of Inventors in 2022 and as a member of the University Academy of Distinguished Scholars in 2023, the highest honor and recognition at UTA. He also served as the Director of the Center for Security Advances Via Applied Nanotechnology (SAVANT) from 2012 to 2018, showcasing his leadership and vision in the field. He used to be the deputy director of the Laboratory of Semiconductor Materials at the Institute of Semiconductors, CAS, and he received the Outstanding Young Scientist Award from CAS.
2,*
1
School of Chemical Engineering, University of Science and Technology Liaoning, Anshan 114051, China
2
School of Chips, XJTLU Entrepreneur College (Taicang), Xi’an Jiaotong-Liverpool University, Taicang, Suzhou 215400, China
*
Authors to whom correspondence should be addressed.
Nanomaterials 2024, 14(17), 1430; https://doi.org/10.3390/nano14171430 (registering DOI)
Submission received: 26 July 2024
/
Revised: 29 August 2024
/
Accepted: 30 August 2024
/
Published: 31 August 2024
Abstract
A biocompatible, highly sensitive, and enzyme-free glucose electrochemical sensor was developed based on a copper-cysteamine (Cu-Cy)-modified electrode. The catalytically active biocompatible material Cu-Cy was immobilized on the electrode surface by the natural polymer chitosan (CTS). The electrochemical characterization and glucose response of the Cu-Cy/CTS/glassy carbon electrode (GCE) were investigated by electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and constant potential amperometry. The significant electrocatalytic activity of Cu-Cy to the oxidation of glucose in an alkaline environment was revealed. Several crucial parameters, including the number of scanning cycles for electrode activation, applied potential, and the contents of Cu-Cy and chitosan, were investigated to understand their impact on the sensor’s response. The proposed sensing platform exhibited linear ranges of 2.7 μM to 1.3 mM and 1.3 mM to 7.7 mM for glucose detection, coupled with high sensitivity (588.28 and 124.42 μA·mM⁻¹·cm⁻²), and commendable selectivity and stability. Moreover, a Cu-Cy/CTS-modified screen-printed electrode (SPE) was further developed for portable direct detection of glucose in real samples.
Share and Cite
MDPI and ACS Style
Chen, H.; Gu, T.; Lv, L.; Chen, X.; Lu, Q.; Kotb, A.; Chen, W.
A Biocompatible, Highly Sensitive, and Non-Enzymatic Glucose Electrochemical Sensor Based on a Copper-Cysteamine (Cu-Cy)/Chitosan-Modified Electrode. Nanomaterials 2024, 14, 1430.
https://doi.org/10.3390/nano14171430
AMA Style
Chen H, Gu T, Lv L, Chen X, Lu Q, Kotb A, Chen W.
A Biocompatible, Highly Sensitive, and Non-Enzymatic Glucose Electrochemical Sensor Based on a Copper-Cysteamine (Cu-Cy)/Chitosan-Modified Electrode. Nanomaterials. 2024; 14(17):1430.
https://doi.org/10.3390/nano14171430
Chicago/Turabian Style
Chen, Huan, Tingting Gu, Longyang Lv, Xing Chen, Qifeng Lu, Amer Kotb, and Wei Chen.
2024. "A Biocompatible, Highly Sensitive, and Non-Enzymatic Glucose Electrochemical Sensor Based on a Copper-Cysteamine (Cu-Cy)/Chitosan-Modified Electrode" Nanomaterials 14, no. 17: 1430.
https://doi.org/10.3390/nano14171430
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details
here.
Article Metrics
Article metric data becomes available approximately 24 hours after publication online.