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Article

A Biocompatible, Highly Sensitive, and Non-Enzymatic Glucose Electrochemical Sensor Based on a Copper-Cysteamine (Cu-Cy)/Chitosan-Modified Electrode

by
Huan Chen
1,
Tingting Gu
1,*,
Longyang Lv
1,
Xing Chen
1,
Qifeng Lu
2,
Amer Kotb
2 and
Wei Chen
2,*
1
School of Chemical Engineering, University of Science and Technology Liaoning, Anshan 114051, China
2
School of Chips, XJTLU Entrepreneur College (Taicang), Xi’an Jiaotong-Liverpool University, Taicang, Suzhou 215400, China
*
Authors to whom correspondence should be addressed.
Nanomaterials 2024, 14(17), 1430; https://doi.org/10.3390/nano14171430 (registering DOI)
Submission received: 26 July 2024 / Revised: 29 August 2024 / Accepted: 30 August 2024 / Published: 31 August 2024
(This article belongs to the Section Biology and Medicines)

Abstract

A biocompatible, highly sensitive, and enzyme-free glucose electrochemical sensor was developed based on a copper-cysteamine (Cu-Cy)-modified electrode. The catalytically active biocompatible material Cu-Cy was immobilized on the electrode surface by the natural polymer chitosan (CTS). The electrochemical characterization and glucose response of the Cu-Cy/CTS/glassy carbon electrode (GCE) were investigated by electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and constant potential amperometry. The significant electrocatalytic activity of Cu-Cy to the oxidation of glucose in an alkaline environment was revealed. Several crucial parameters, including the number of scanning cycles for electrode activation, applied potential, and the contents of Cu-Cy and chitosan, were investigated to understand their impact on the sensor’s response. The proposed sensing platform exhibited linear ranges of 2.7 μM to 1.3 mM and 1.3 mM to 7.7 mM for glucose detection, coupled with high sensitivity (588.28 and 124.42 μA·mM⁻¹·cm⁻²), and commendable selectivity and stability. Moreover, a Cu-Cy/CTS-modified screen-printed electrode (SPE) was further developed for portable direct detection of glucose in real samples.
Keywords: copper-cysteamine (Cu-Cy); electrochemical sensor; glucose; enzyme-free copper-cysteamine (Cu-Cy); electrochemical sensor; glucose; enzyme-free

Share and Cite

MDPI and ACS Style

Chen, H.; Gu, T.; Lv, L.; Chen, X.; Lu, Q.; Kotb, A.; Chen, W. A Biocompatible, Highly Sensitive, and Non-Enzymatic Glucose Electrochemical Sensor Based on a Copper-Cysteamine (Cu-Cy)/Chitosan-Modified Electrode. Nanomaterials 2024, 14, 1430. https://doi.org/10.3390/nano14171430

AMA Style

Chen H, Gu T, Lv L, Chen X, Lu Q, Kotb A, Chen W. A Biocompatible, Highly Sensitive, and Non-Enzymatic Glucose Electrochemical Sensor Based on a Copper-Cysteamine (Cu-Cy)/Chitosan-Modified Electrode. Nanomaterials. 2024; 14(17):1430. https://doi.org/10.3390/nano14171430

Chicago/Turabian Style

Chen, Huan, Tingting Gu, Longyang Lv, Xing Chen, Qifeng Lu, Amer Kotb, and Wei Chen. 2024. "A Biocompatible, Highly Sensitive, and Non-Enzymatic Glucose Electrochemical Sensor Based on a Copper-Cysteamine (Cu-Cy)/Chitosan-Modified Electrode" Nanomaterials 14, no. 17: 1430. https://doi.org/10.3390/nano14171430

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