NIR-II Aggregation-Induced Emission Luminogens for Tumor Phototheranostics
Abstract
:1. Introduction
2. NIR-II FLI-Guided PTT
3. PAI-Guided PTT Based on NIR-II Fluorophores
4. Multimodal Imaging-Guided Synergistic Therapy
4.1. NIR-II FLI-Guided PDT–PTT Synergistic Therapy
4.2. NIR-II FLI–PAI–PTI Trimodal-Guided Synergistic PDT–PTT
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Name | Chemical Structure | λAbs/λem (nm) | Extinction Coefficient | QY | Photothermal Conversion |
---|---|---|---|---|---|
BPBBT | | ≈705/ ≈1020 (in water, NPs) | 0.9 × 104 M−1·cm−1 at 808 nm | 0.145% [a] (NPs) | 27.5% (NPs, 808 nm laser) |
PBPTV | | ≈700/≈960 (in water, NPs) | N.A. | 8.6% [b] (in DCM) | 45.3% (NPs, 808 nm laser) |
DTPA–BBTD | | 752/975 (in THF) | 7.09 L·g−1·cm−1 at 753 nm | 0.151% [a] (NPs) | 13.2% (NPs, 660 nm laser) |
NIRb14 | | 822/1090 (in THF) | N.A | N.A. | 31.2% (NPs, 808 nm laser) |
BITT | | 595/741 (in ethanol) | 3.9 × 104 M−1·cm−1 | 5.8% [b] (aggregate) | 35.76% (660 nm laser) |
TSSI | | 636/992 (in water, NPs) | N.A. | N.A. | 46.0% (NPs, 660 nm laser) |
TSSAM | | 595/1022 (in DMSO) | N.A. | 0.034% [a] (NPs) | 40.1% (NPs, 660 nm laser) |
TTT-4 | | 568/830 (in DMSO) | N.A. | 0.8%[b] (aggregate, DMSO:toluene = 19:1) | 39.9% (NPs, 660 nm laser) |
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Tan, Y.; Liu, P.; Li, D.; Wang, D.; Tang, B.Z. NIR-II Aggregation-Induced Emission Luminogens for Tumor Phototheranostics. Biosensors 2022, 12, 46. https://doi.org/10.3390/bios12010046
Tan Y, Liu P, Li D, Wang D, Tang BZ. NIR-II Aggregation-Induced Emission Luminogens for Tumor Phototheranostics. Biosensors. 2022; 12(1):46. https://doi.org/10.3390/bios12010046
Chicago/Turabian StyleTan, Yonghong, Peiying Liu, Danxia Li, Dong Wang, and Ben Zhong Tang. 2022. "NIR-II Aggregation-Induced Emission Luminogens for Tumor Phototheranostics" Biosensors 12, no. 1: 46. https://doi.org/10.3390/bios12010046