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Volume 12
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Article

Fabry-Perot Interferometer Based on a Fiber-Tip Fixed-Supported Bridge for Fast Glucose Concentration Measurement

by
Shuo Tang
1,
Mengqiang Zou
2,3,
Cong Zhao
2,3,
Yihang Jiang
1,
Ribao Chen
1,
Zhourui Xu
1,
Chengbin Yang
1,
Xiaomei Wang
4,
Biqin Dong
5,
Yiping Wang
2,3,
Changrui Liao
2,3,* and
Gaixia Xu
1,*
1
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering Health Science Center, Shenzhen University, Shenzhen 518055, China
2
Shenzhen Key Laboratory of Photonic Devices and Sensing Systems for Internet of Things, Guangdong and Hong Kong Joint Research Centre for Optical Fiber Sensors, Shenzhen University, Shenzhen 518060, China
3
Key Laboratory of Optoelectronic Devices and Systems of the Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
4
Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, Shenzhen Key Laboratory of Synthetic Biology, Department of Physiology, School of Basic Medical Sciences Shenzhen University, Shenzhen 518055, China
5
Department of Civil Engineering, Guangdong Province Key Laboratory of Durability for Marine Civil Engineering, The Key Laboratory on Durability of Civil Engineering in Shenzhen, Shenzhen University, Shenzhen 518060, China
*
Authors to whom correspondence should be addressed.
Biosensors 2022, 12(6), 391; https://doi.org/10.3390/bios12060391
Submission received: 7 May 2022 / Revised: 31 May 2022 / Accepted: 2 June 2022 / Published: 6 June 2022
(This article belongs to the Section Biosensor and Bioelectronic Devices)
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Abstract

Blood glucose concentration is important for metabolic homeostasis in humans and animals. Many diabetic patients need to detect blood glucose daily which burdens community hospitals and family healthcare. Optical fiber sensors are widely used in biomedical detection because of their compact structure, fast response, high sensitivity, low cost, and ease of operation. In this work, we constructed a Fabry-Perot (FP) cavity biosensor for the fast detection of glucose concentration in serum. The femtosecond laser micromachining was applied to fabricate the FP cavity by printing the fiber-tip fixed-supported bridge at the end face of the optical fiber. An additional hemisphere was printed at the center of the outer surface of the bridge to avoid multi-beam interference. The results demonstrated that the proposed biosensor had high refractive index (RI) detection sensitivity, roughly 1039 nm/RIU at a wavelength of 1590 nm, and the detection sensitivity for glucose was around 0.185 nm/ (mg/mL) at a wavelength of 1590 nm. Due to its high sensitivity, compact structure, and fast response, the FP cavity biosensor has great potential to be applied in family healthcare for glucose concentration detection of diabetic patients.
Keywords: optical fiber sensor; Fabry-Perot (FP) cavity biosensor; femtosecond laser micromachining; two-photon polymerization; blood glucose detection optical fiber sensor; Fabry-Perot (FP) cavity biosensor; femtosecond laser micromachining; two-photon polymerization; blood glucose detection

Share and Cite

MDPI and ACS Style

Tang, S.; Zou, M.; Zhao, C.; Jiang, Y.; Chen, R.; Xu, Z.; Yang, C.; Wang, X.; Dong, B.; Wang, Y.; et al. Fabry-Perot Interferometer Based on a Fiber-Tip Fixed-Supported Bridge for Fast Glucose Concentration Measurement. Biosensors 2022, 12, 391. https://doi.org/10.3390/bios12060391

AMA Style

Tang S, Zou M, Zhao C, Jiang Y, Chen R, Xu Z, Yang C, Wang X, Dong B, Wang Y, et al. Fabry-Perot Interferometer Based on a Fiber-Tip Fixed-Supported Bridge for Fast Glucose Concentration Measurement. Biosensors. 2022; 12(6):391. https://doi.org/10.3390/bios12060391

Chicago/Turabian Style

Tang, Shuo, Mengqiang Zou, Cong Zhao, Yihang Jiang, Ribao Chen, Zhourui Xu, Chengbin Yang, Xiaomei Wang, Biqin Dong, Yiping Wang, and et al. 2022. "Fabry-Perot Interferometer Based on a Fiber-Tip Fixed-Supported Bridge for Fast Glucose Concentration Measurement" Biosensors 12, no. 6: 391. https://doi.org/10.3390/bios12060391

APA Style

Tang, S., Zou, M., Zhao, C., Jiang, Y., Chen, R., Xu, Z., Yang, C., Wang, X., Dong, B., Wang, Y., Liao, C., & Xu, G. (2022). Fabry-Perot Interferometer Based on a Fiber-Tip Fixed-Supported Bridge for Fast Glucose Concentration Measurement. Biosensors, 12(6), 391. https://doi.org/10.3390/bios12060391

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