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Biosensors
Volume 13
Issue 3
10.3390/bios13030366
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Article

Ultrasensitive Photoelectrochemical Immunoassay Strategy Based on Bi2S3/Ag2S for the Detection of the Inflammation Marker Procalcitonin

by
Guanhui Zhao
1,
Yingying Wang
2,
Huixin Wang
2,
Guozhen Bai
1,
Nuo Zhang
1,*,
Yaoguang Wang
2,* and
Qin Wei
1
1
Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
2
Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China
*
Authors to whom correspondence should be addressed.
Biosensors 2023, 13(3), 366; https://doi.org/10.3390/bios13030366
Submission received: 28 January 2023 / Revised: 22 February 2023 / Accepted: 8 March 2023 / Published: 10 March 2023
(This article belongs to the Special Issue Application of Nanomaterials for Biosensors)
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Abstract

As an inflammatory marker, procalcitonin (PCT) is more representative than other traditional inflammatory markers. In this work, a highly efficient photoelectrochemical (PEC) immunosensor was constructed based on the photoactive material Bi2S3/Ag2S to realize the sensitive detection of PCT. Bi2S3 was prepared by a hydrothermal method, and Ag2S quantum dots were deposited on the ITO/Bi2S3 surface via in situ reduction. Bi2S3 is a kind of admirable photoelectric semiconductor nanomaterial on account of its moderate bandgap width and low binding rate of photogenerated electron holes, which can effectively convert light energy into electrical energy. Therefore, based on the energy level matching principle of Bi2S3 and Ag2S, a labeled Bi2S3/Ag2S PEC immunosensor was constructed, and the sensitive detection of PCT was successfully established. The linear detection range of the PEC immunosensor was 0.50 pg∙mL−1 to 50 ng∙mL−1, and the minimum detection limit was 0.18 pg∙mL−1. Compared with the traditional PEC strategy, the proposed PEC immunosensor is simple, convenient, and has good anti-interference, sensitivity, and specificity, which could provide a meaningful theoretical basis and reference value for the clinical detection of PCT.
Keywords: photoelectric chemical immunosensor; procalcitonin; semiconductor nanomaterial; Bi2S3; Ag2S photoelectric chemical immunosensor; procalcitonin; semiconductor nanomaterial; Bi2S3; Ag2S

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MDPI and ACS Style

Zhao, G.; Wang, Y.; Wang, H.; Bai, G.; Zhang, N.; Wang, Y.; Wei, Q. Ultrasensitive Photoelectrochemical Immunoassay Strategy Based on Bi2S3/Ag2S for the Detection of the Inflammation Marker Procalcitonin. Biosensors 2023, 13, 366. https://doi.org/10.3390/bios13030366

AMA Style

Zhao G, Wang Y, Wang H, Bai G, Zhang N, Wang Y, Wei Q. Ultrasensitive Photoelectrochemical Immunoassay Strategy Based on Bi2S3/Ag2S for the Detection of the Inflammation Marker Procalcitonin. Biosensors. 2023; 13(3):366. https://doi.org/10.3390/bios13030366

Chicago/Turabian Style

Zhao, Guanhui, Yingying Wang, Huixin Wang, Guozhen Bai, Nuo Zhang, Yaoguang Wang, and Qin Wei. 2023. "Ultrasensitive Photoelectrochemical Immunoassay Strategy Based on Bi2S3/Ag2S for the Detection of the Inflammation Marker Procalcitonin" Biosensors 13, no. 3: 366. https://doi.org/10.3390/bios13030366

APA Style

Zhao, G., Wang, Y., Wang, H., Bai, G., Zhang, N., Wang, Y., & Wei, Q. (2023). Ultrasensitive Photoelectrochemical Immunoassay Strategy Based on Bi2S3/Ag2S for the Detection of the Inflammation Marker Procalcitonin. Biosensors, 13(3), 366. https://doi.org/10.3390/bios13030366

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