Advances in Point-of-Care Testing of microRNAs Based on Portable Instruments and Visual Detection
Abstract
:1. Introduction
2. POCT of miRNAs
2.1. POCT of miRNAs Based on Portable Instruments
2.1.1. miRNA Detection Based on a Personal Glucose Meter
2.1.2. Detection of miRNAs Based on a Thermometer
2.1.3. Detection of miRNAs Based on a Pressure Meter
2.1.4. Detection of miRNAs Based on Portable Fluorometers
2.1.5. Detection of miRNAs Based on a Capillary Force Meter
2.1.6. Detection of miRNAs Based on Smartphones
Methods | miRNA | Detection Limit | Samples | Time | Reference |
---|---|---|---|---|---|
Personal glucose meter | miR-21 | 0.41 nM/ 1 million cells | synthesized miR-21/A549 cell lysates | <2 h | [21] |
miR-21 | 10 fM | synthesized miR-21 | <2 h | [23] | |
miR-21 miRNA205 | 2.4 pM 1.1 pM | synthesized miR-21 synthesized miRNA205 | <3 h | [26] | |
miR-21 | 3.65 nM | synthesized miR-21 clinical serum samples from cancer patients | 2 h | [22] | |
miR-21 | 60 pM 3 × 106 cells/mL | synthesized miR-21 MCF-7, A549 and HeLa cell lysates | <3 h | [24] | |
miR-21 | 68.08 fM | synthesized miR-21 urine samples from DIKI mice | 1.5 h | [25] | |
miRNA-155 | 0.36 fM | synthesized miRNA-155 | >5 h | [27] | |
miR-21, miR-335, miR-155, and miR-122 | 0.325 fmol | synthesized miRNAs extract from HeLa, HepG2, MCF-7, and L02 Cells | 6 h | [28] | |
Thermometer | miR-21 | 7.8 nM | synthesized miR-21 HeLa cell lysate | Not mentioned | [35] |
miRNA-141 | 0.5 pM | synthesized miRNA-141 | >8 h | [36] | |
Pressure meter | miR-21 | 7.6 fM 100 cells | synthesized miR-21 A549, MCF-7, HepG2 and HL-7702 cells | 20 min | [38] |
miR-21 | 10 pM | Serum | 0.5 h | [39] | |
Portable fluorometer | miR-574-5p | 2 ng/μL | RNA extract from 5XFAD mice | >3 h | [40] |
Capillary force meter | miR-21 | 10 nM | Human serum | 1 h | [43] |
miR-21 | MCF-7 cell line | 25 min | [44] | ||
Smartphone | miR-133a | 0.3 pM | synthesized miR-133a in serum | >5 h | [50] |
miRNA-499, miRNA-133a | 10 fM | synthesized miR-133a in serum | 13 h | [51] | |
let-7a | 1.7 fM | synthesized let-7a human serum | 2.75 h | [56] | |
miR-133a, miR-499 | 1 fM | Synthesized miRNAs human serum | - | [52] | |
miR-21, let-7a | fM | Synthesized miRNAs human serum | <2 h | [49] | |
miR-21 | 1.43 pM | Synthesized miR-21 human serum, urine | 0.5 h | [58] | |
miR-224 | 1.6 fM | Synthesized miR-224 human plasma | <4.5 h | [59] | |
miR-21 | 100 fM 500 cells | Synthesized miR-21 MCF-7 and L02 cells | >1 h | [57] |
2.2. Visual Detection of miRNAs Based on Colorimetry
2.2.1. Colorimetric Detection Based on Au-NPs
2.2.2. Colorimetric Method Based on Enzymatic Chromogenic Reactions
Methods | miRNA | Detection Limit | Samples | Time | Reference |
---|---|---|---|---|---|
Colorimetric detection based on Au-NPs | miR-21 miR-155 | 5 ng μL−1 | Plasma | <3 min | [63] |
miR-93 miR-223 | - | Human serum | - | [64] | |
miR-34a miR-210 | 50 ng μL−1 | Urine | <20 min | [66] | |
miR-195 | 40 fM | Human serum | 10 min | [67] | |
miR-210-3p | 10 pM | Urine | 20 min | [68] | |
miR-21 miR-155 | 1 ng μL−1 | Multiple cancerous cell lines and primary fibroblast | <10 min | [69] | |
miR-21 miR-141 | 3 pM | Synthesized miRNA human serum samples | <5 h | [70] | |
miR-137 | 0.5 nM | Plasma | 1 min | [72] | |
miR-146a | 5 nM | Raw cow milk | 20 min | [76] | |
let-7a | 0.13 pM | A549 cells | 50 min | [81] | |
miR-148a | 1.9 nM | Plasma | 5 min | [75] | |
miR-122 | 16 pM | Cancerous cell lines | 2 h | [79] | |
let-7a | 3.13 fM | Human serum | 1 h | [80] | |
miR-203 | 10 pM | MCF-7 cells | - | [82] | |
miR-21 | 0.23 fM | HeLa, MCF-7, AGS cells | 0.5 h | [84] | |
let-7a | 4.176 aM | Synthesized let-7a | 1 h | [83] | |
miR-221-3p | 46 fM | BEL-7404, MDA-MB231, HeLa, and 22Rv1cells | 1 h | [85] | |
miR-143 | 1 fM | Synthesized miR-143 Prostate cancer cell lines VCaP, LNCaP, Du145, and PC-3 | >1.5 h | [87] | |
Colorimetric detection based on enzymatic chromogenic reactions | let-7a | 7.4 fM | Synthesized let-7a | 2.5 h | [92] |
miR-122 | 0.15 aM | Serum | 5 min | [93] | |
miR-21 | 0.2 pM | Serum | 50 min | [94] | |
miR-21 | 1 aM | Serum | <4 h | [95] | |
Let-7a | 34 fM | A549 cells | 4 h | [96] | |
miR-10b | 1 fM | Serum and cell extracts | 20 min | [97] | |
miR-141 | 0.48 nM | Serum | >3 h | [100] | |
miR-21 | 1 pM | Serum | 150 min | [102] | |
miR-141 | 0.5 pM | Prostate cancer cells | 210 min | [104] | |
miR-21 | 90.3 fM | Serum | <1.5 h | [105] | |
miR-21, miR-17 | 1.7 fM | MCF-7 | 80 min | [106] | |
let-7a | 0.1 nM | Serum | 3 min | [108] | |
miR-21 | 44.76 fM | Exosome | 2 h | [111] | |
miR-21, miR-155 | 0.38 nM | Blood | >1 h | [112] | |
miR-21 | 4.5 nM | MCF-7 and serum | 130 min | [113] | |
miR-21 | 5 fM | Plasma sample Cancer cells Tumor tissues | >6.5 h | [109] | |
miR-155 | 0.6 pM | Plasma | 15 min | [115] | |
miR-205, miR-944 | 36.4 fM | Serum | >2 h | [116] | |
miR-155 | 31.8 fM | Serum | 1 h | [117] | |
miR-223 miR-143 | 20 pM | Synthesized miR-223 iPSCs and CMs | 3.5 h | [118] |
3. Conclusions and Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Wang, Z.-Y.; Sun, M.-H.; Zhang, Q.; Li, P.-F.; Wang, K.; Li, X.-M. Advances in Point-of-Care Testing of microRNAs Based on Portable Instruments and Visual Detection. Biosensors 2023, 13, 747. https://doi.org/10.3390/bios13070747
Wang Z-Y, Sun M-H, Zhang Q, Li P-F, Wang K, Li X-M. Advances in Point-of-Care Testing of microRNAs Based on Portable Instruments and Visual Detection. Biosensors. 2023; 13(7):747. https://doi.org/10.3390/bios13070747
Chicago/Turabian StyleWang, Zhong-Yu, Ming-Hui Sun, Qun Zhang, Pei-Feng Li, Kun Wang, and Xin-Min Li. 2023. "Advances in Point-of-Care Testing of microRNAs Based on Portable Instruments and Visual Detection" Biosensors 13, no. 7: 747. https://doi.org/10.3390/bios13070747