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Review

Plasmonic Fluorescence Sensors in Diagnosis of Infectious Diseases

by
Juiena Hasan
and
Sangho Bok
*
Department of Electrical and Computer Engineering, Ritchie School of Engineering and Computer Science, University of Denver, Denver, CO 80208, USA
*
Author to whom correspondence should be addressed.
Biosensors 2024, 14(3), 130; https://doi.org/10.3390/bios14030130
Submission received: 8 January 2024 / Revised: 25 February 2024 / Accepted: 26 February 2024 / Published: 2 March 2024
(This article belongs to the Special Issue Plasmonic Based Biosensors)

Abstract

The increasing demand for rapid, cost-effective, and reliable diagnostic tools in personalized and point-of-care medicine is driving scientists to enhance existing technology platforms and develop new methods for detecting and measuring clinically significant biomarkers. Humanity is confronted with growing risks from emerging and recurring infectious diseases, including the influenza virus, dengue virus (DENV), human immunodeficiency virus (HIV), Ebola virus, tuberculosis, cholera, and, most notably, SARS coronavirus-2 (SARS-CoV-2; COVID-19), among others. Timely diagnosis of infections and effective disease control have always been of paramount importance. Plasmonic-based biosensing holds the potential to address the threat posed by infectious diseases by enabling prompt disease monitoring. In recent years, numerous plasmonic platforms have risen to the challenge of offering on-site strategies to complement traditional diagnostic methods like polymerase chain reaction (PCR) and enzyme-linked immunosorbent assays (ELISA). Disease detection can be accomplished through the utilization of diverse plasmonic phenomena, such as propagating surface plasmon resonance (SPR), localized SPR (LSPR), surface-enhanced Raman scattering (SERS), surface-enhanced fluorescence (SEF), surface-enhanced infrared absorption spectroscopy, and plasmonic fluorescence sensors. This review focuses on diagnostic methods employing plasmonic fluorescence sensors, highlighting their pivotal role in swift disease detection with remarkable sensitivity. It underscores the necessity for continued research to expand the scope and capabilities of plasmonic fluorescence sensors in the field of diagnostics.
Keywords: plasmonics; SPR; LSPR; infectious disease; biosensors; fluorescence plasmonics; SPR; LSPR; infectious disease; biosensors; fluorescence

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MDPI and ACS Style

Hasan, J.; Bok, S. Plasmonic Fluorescence Sensors in Diagnosis of Infectious Diseases. Biosensors 2024, 14, 130. https://doi.org/10.3390/bios14030130

AMA Style

Hasan J, Bok S. Plasmonic Fluorescence Sensors in Diagnosis of Infectious Diseases. Biosensors. 2024; 14(3):130. https://doi.org/10.3390/bios14030130

Chicago/Turabian Style

Hasan, Juiena, and Sangho Bok. 2024. "Plasmonic Fluorescence Sensors in Diagnosis of Infectious Diseases" Biosensors 14, no. 3: 130. https://doi.org/10.3390/bios14030130

APA Style

Hasan, J., & Bok, S. (2024). Plasmonic Fluorescence Sensors in Diagnosis of Infectious Diseases. Biosensors, 14(3), 130. https://doi.org/10.3390/bios14030130

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