Recent Advances in Nanomaterials for Modulation of Stem Cell Differentiation and Its Therapeutic Applications
Abstract
:1. Introduction
2. Metal-Based Stem Cell Differentiation Approaches and Therapeutics
2.1. Autophagy
2.2. ROS Scavenger
3. Carbon-Based Stem Cell Differentiation Approaches and Therapeutics
3.1. Electrical Signals to Enhance Stem Cell Differentiation
3.2. Hydrogel Formation
4. Other Nanomaterials for Stem Cell Differentiation and Therapeutics Applications
4.1. Metal–Organic Framework
4.2. Upconversion Nanoparticles
5. Conclusions and Future Perspectives
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Nanomaterials | Lineages | Cells | Mechanism of Actions | Therapeutic Applications | Ref. |
---|---|---|---|---|---|
AuNPs | Osteogenic differentiation | MSCs | ROS scavenging | Periodontitis | [76] |
CaFO NPs (calcium folate) | Neuronal differentiation | Mouse embryonic-derived NSCs | Decomposition into Ca2+ and folic acid | Alzheimer’s disease | [77] |
SPIO-AuNPs | Neuronal differentiation | PC-12 | Dynamic magnetic field to Ca2+ influx | Alzheimer’s disease | [78] |
AuNPs | Neuronal differentiation | Embryonic-derived NPCs | GFAP barriers from activated astrocytes | Spinal cord injury | [79] |
L/D-Au nanocluster films | Adipogenic/ Osteogenic differentiation | MSCs | Chirality at cluster scale to control cellular behaviors | Functional maintenance in organisms | [80] |
Chitosan-AuNPs | Neuronal differentiation | MSCs | Strengthen MSC colony formation | Neurodegenerative diseases | [81] |
Chiral AuNPs | Neuronal differentiation | Mouse neural NSCs | CPL illumination to direct differentiation | Alzheimer’s disease | [82] |
CeO2 NPs | Osteogenic differentiation | MC3T3-E1 | Activating the Wnt pathway | Bone metabolic disease | [83] |
AgNPs-Ca(OH)2 | Osteogenic differentiation | MSCs | Upregulation of TGF-β1 | Necrosis in immature teeth | [84] |
Nanomaterials | Lineages | Cells | Mechanism of Actions | Therapeutic Applications | Ref. |
---|---|---|---|---|---|
Graphene oxide | Chondrogenic differentiation | MSCs | Activating osmosensitive receptor | Cartilage repair | [109] |
Graphene oxide QDs | Osteogenic differentiation | MSCs | Promoting mitochondrial dynamics | Bone defects | [110] |
3DGp/CNT scaffolds | Osteogenic differentiation | MSCs | Upregulation of BMP pathway | Dental clinical engineering | [111] |
CNTs | Neuronal differentiation | NSCs | Enhancing cellular attachment and communication | Neurological diseases and injuries | [112] |
Carbon nanofibers | Neuronal differentiation | MSCs | Increasing cellular connection | Neural tissue regeneration | [113] |
Silk fibroin/ carbon nanofiber scaffolds | Cardiomyogenic differentiation | iPSCs | Mimicking mechanical/physical properties of cardiac tissue | Heart failure | [114] |
CNTs | Neuronal differentiation | NSCs | Regulating focal adhesion, calcium ion channels/ PI3K-AK pathways | Cortical injury | [115] |
Nanomaterials | Lineages | Cells | Mechanisms | Therapeutic Applications | Ref. |
---|---|---|---|---|---|
Stem cell membrane/ZIF-8 | Osteogenic differentiation | MSCs | Improve the targeted internalization of nanoparticles | Bone regeneration | [139] |
Dexamethasone/ZIF-8 | Osteogenic differentiation | MSCs | Activation of PI3K-Akt signaling pathways | Bone regeneration | [140] |
ZIF-8/GelMA hydrogel | Neuronal differentiation | DPSCs | Activation of MAPK signaling pathway | Spinal cord injury | [141] |
Porous carbon nanozyme/HOFs | Neuronal differentiation | NSCs | Oxidative stress resistance, drug carrier | Alzheimer’s disease | [142] |
Ce/Sr dual-loaded bio-MOF | Osteogenic differentiation | MSCs | Restore mitochondrial dynamics and normalize senescent MSCs | Osteoporotic fracture | [143] |
Zn/Co-MOF/β-TCP scaffolds | Osteogenic/ chondrogenic differentiation | MSCs | ROS scavenging | Osteoarthritis | [144] |
UCNPs-F127@Cur | Glioma stem cells | NIH3T3 | Suppressing the Wnt-β-catenin and Jak-Stat pathways | Glioblastoma | [145] |
PLLA nanofiber | Neural differentiation | NSCs | Piezoelectric charge to topographical stimulation | Neural tissue repair | [146] |
Single-chain atomic crystal | Neural differentiation | ESCs | Supporting adhesion and growth | Neurodegenerative disease | [147] |
Graphene derivatives/CeO2-nanoparticle-containing hydrogels | Neuronal differentiation | NSCs | Self-assembly of graphene oxide sheets incorporating a reducing agent and CeO2 nanoparticles | Neuroregenerative cell therapies | [148] |
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Kim, C.-D.; Koo, K.-M.; Kim, H.-J.; Kim, T.-H. Recent Advances in Nanomaterials for Modulation of Stem Cell Differentiation and Its Therapeutic Applications. Biosensors 2024, 14, 407. https://doi.org/10.3390/bios14080407
Kim C-D, Koo K-M, Kim H-J, Kim T-H. Recent Advances in Nanomaterials for Modulation of Stem Cell Differentiation and Its Therapeutic Applications. Biosensors. 2024; 14(8):407. https://doi.org/10.3390/bios14080407
Chicago/Turabian StyleKim, Chang-Dae, Kyeong-Mo Koo, Hyung-Joo Kim, and Tae-Hyung Kim. 2024. "Recent Advances in Nanomaterials for Modulation of Stem Cell Differentiation and Its Therapeutic Applications" Biosensors 14, no. 8: 407. https://doi.org/10.3390/bios14080407