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Antibiotics
Volume 10
Issue 6
10.3390/antibiotics10060631
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Article
Peer-Review Record

Attenuation of Aeromonas hydrophila Infection in Carassius auratus by YtnP, a N-acyl Homoserine Lactonase from Bacillus licheniformis T-1

Antibiotics 2021, 10(6), 631; https://doi.org/10.3390/antibiotics10060631
by Mengfan Peng 1, Wentao Tong 1, Zhen Zhao 1, Ling Xiao 1, Zhaoyue Wang 1, Xuanming Liu 1, Xuanhao He 1 and Zengfu Song 1,2,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Antibiotics 2021, 10(6), 631; https://doi.org/10.3390/antibiotics10060631
Submission received: 21 February 2021 / Revised: 27 April 2021 / Accepted: 2 May 2021 / Published: 26 May 2021
(This article belongs to the Special Issue Analysis of Virulence Mechanisms of Bacterial Pathogens in Aquaculture)

Round 1

Reviewer 1 Report

The language and grammar used throughout are a significant limitation to readability. Figure 4B illustrates the findings well but could use a bit more clarity on the labelling.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The study on the Attenuation of Aeromonas hydrophila infection in Carassius auratus by YtnP, a N-acyl homoserine lactonase from Bacillus licheniformis T-1 has been carried very methodically by  the authors. They first characterised the YtnP enzyme and cloned it  to produce enough for further studies. These studies clearly showed its role as a quorum quencher which can increase the potency of some antibiotics. More importantly  they showed its potential in reducing biofilm production  by the pathogen which results in a slower infection. Overall I am pleased with the outcomes of the study. However there are too many typographical and grammatical errors which calls for a major editing job to be undertaken.

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 3 Report

The manuscript can be accepted after minor revisions in abstract and introduction. Abstract needs to be short and concise. Introduction should include the prior studies on A. hydrophila.

Author Response

Please see the attachmen

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

The results and materials and methods are improved with results to grammar and formatting, but significant editing of the introduction would add interest and more effectively engage the reader.

Author Response

pleas see the attachement

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