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Article

Antibiotic Prescribing Patterns in Ghana, Uganda, Zambia and Tanzania Hospitals: Results from the Global Point Prevalence Survey (G-PPS) on Antimicrobial Use and Stewardship Interventions Implemented

by
Nikki D’Arcy
1,
Diane Ashiru-Oredope
1,*,
Omotayo Olaoye
1,
Daniel Afriyie
2,
Zainab Akello
3,
Daniel Ankrah
4,
Derrick Mawuena Asima
5,
David C. Banda
6,
Scott Barrett
7,
Claire Brandish
8,
Joseph Brayson
7,
Peter Benedict
9,
Cornelius C. Dodoo
10,
Frances Garraghan
11,
Josephyn Hoyelah, Sr.
12,
Yogini Jani
13,
Freddy Eric Kitutu
14,
Ismail Musoke Kizito
15,
Appiah-Korang Labi
16,
Mariyam Mirfenderesky
17,
Sudaxshina Murdan
18,
Caoimhe Murray
19,
Noah Obeng-Nkrumah
20,
William J’Pathim Olum
21,
Japheth Awuletey Opintan
16,
Edwin Panford-Quainoo
22,
Ines Pauwels
23,
Israel Sefah
24,
Jacqueline Sneddon
25,
Anja St. Clair Jones
26 and
Ann Versporten
23add Show full author list remove Hide full author list
1
Commonwealth Partnerships Programme on Antimicrobial Stewardship, Commonwealth Pharmacists Association, London E1W 1AW, UK
2
Pharmacy Department, Ghana Police Hospital, Accra P.O. Box CT104, Ghana
3
Laro Division, Gulu Regional Referral Hospital, Gulu P.O. Box 166, Uganda
4
Korle-Bu Teaching Hospital, Accra P.O. Box 77, Ghana
5
LEKMA Hospital, P.M. B Teshie, Nungua, Accra P.O. Box CT104, Ghana
6
Department of Pharmacy, University Teaching Hospital, Lusaka P.O. Box 50001, Zambia
7
Pharmacy Department, North Tyneside Hospital, Northumbria Healthcare NHS Foundation Trust, Rake Lane, North Shields NE29 8NH, UK
8
Buckinghamshire Healthcare NHS Trust, Amersham HP7 0JD, UK
9
Kilimanjaro Christian Medical Centre, Moshi P.O. Box 3010, Tanzania
10
School of Pharmacy, University of Health and Allied Sciences, PMB 31, Ho, Ghana
11
Manchester University NHS Foundation Trust, Oxford Road, Manchester M13 9WL, UK
12
St. Mary’s Hospital Lacor, Gulu P.O. Box 180, Uganda
13
Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PG, UK
14
Sustainable Pharmaceutical Systems (SPS) Unit, Pharmacy Department, School of Health Sciences, Makerere University, Kampala P.O. Box 7062, Uganda
15
Entebbe Regional Referral Hospital, Entebbe P.O. Box 29, Uganda
16
Medical Microbiology Department, University of Ghana Medical School, Accra P.O. Box GP 4236, Ghana
17
North Middlesex University Hospital NHS Trust, London N18 1QX, UK
18
UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK
19
St. Francis Hospital, Katete Private Bag 11, Zambia
20
Department of Medical Laboratory Sciences, University of Ghana School of Biomedical and Allied Health Sciences, Accra P.O. Box LG 25, Ghana
21
Jinja Regional Referral Hospital, Jinja P.O. Box 43, Uganda
22
Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
23
Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
24
Department of Pharmacy, Keta Municipal Hospital, Keta-Dzelukope P.O. Box WT82, Ghana
25
Scottish Antimicrobial Prescribing Group, Healthcare Improvement Scotland, Delta House, 50 West Nile Street, Glasgow G1 2NP, UK
26
Brighton and Sussex University Hospitals NHS Trust, Brighton BN1 9PX, UK
 
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*
Author to whom correspondence should be addressed.
Antibiotics 2021, 10(9), 1122; https://doi.org/10.3390/antibiotics10091122
Submission received: 24 July 2021 / Revised: 3 September 2021 / Accepted: 13 September 2021 / Published: 17 September 2021
(This article belongs to the Special Issue Antimicrobial Prescribing and Stewardship, 2nd Volume)
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Abstract

Antimicrobial resistance (AMR) remains an important global public health issue with antimicrobial misuse and overuse being one of the main drivers. The Global Point Prevalence Survey (G-PPS) of Antimicrobial Consumption and Resistance assesses the prevalence and the quality of antimicrobial prescriptions across hospitals globally. G-PPS was carried out at 17 hospitals across Ghana, Uganda, Zambia and Tanzania. The overall prevalence of antimicrobial use was 50% (30–57%), with most antibiotics prescribed belonging to the WHO ‘Access’ and ‘Watch’ categories. No ‘Reserve’ category of antibiotics was prescribed across the study sites while antimicrobials belonging to the ‘Not Recommended’ group were prescribed infrequently. Antimicrobials were most often prescribed for prophylaxis for obstetric or gynaecological surgery, making up between 12 and 18% of total prescriptions across all countries. The most prescribed therapeutic subgroup of antimicrobials was ‘Antibacterials for systemic use’. As a result of the programme, PPS data are now readily available for the first time in the hospitals, strengthening the global commitment to improved antimicrobial surveillance. Antimicrobial stewardship interventions developed included the formation of AMS committees, the provision of training and the preparation of new AMS guidelines. Other common interventions included the presentation of findings to clinicians for increased awareness, and the promotion of a multi-disciplinary approach to successful AMS programmes. Repeat PPS would be necessary to continually monitor the impact of interventions implemented. Broader participation is also encouraged to strengthen the evidence base.
Keywords: antimicrobial resistance; global-pps; antimicrobial surveillance; antibiotics; antimicrobials; antimicrobial stewardship antimicrobial resistance; global-pps; antimicrobial surveillance; antibiotics; antimicrobials; antimicrobial stewardship

Share and Cite

MDPI and ACS Style

D’Arcy, N.; Ashiru-Oredope, D.; Olaoye, O.; Afriyie, D.; Akello, Z.; Ankrah, D.; Asima, D.M.; Banda, D.C.; Barrett, S.; Brandish, C.; et al. Antibiotic Prescribing Patterns in Ghana, Uganda, Zambia and Tanzania Hospitals: Results from the Global Point Prevalence Survey (G-PPS) on Antimicrobial Use and Stewardship Interventions Implemented. Antibiotics 2021, 10, 1122. https://doi.org/10.3390/antibiotics10091122

AMA Style

D’Arcy N, Ashiru-Oredope D, Olaoye O, Afriyie D, Akello Z, Ankrah D, Asima DM, Banda DC, Barrett S, Brandish C, et al. Antibiotic Prescribing Patterns in Ghana, Uganda, Zambia and Tanzania Hospitals: Results from the Global Point Prevalence Survey (G-PPS) on Antimicrobial Use and Stewardship Interventions Implemented. Antibiotics. 2021; 10(9):1122. https://doi.org/10.3390/antibiotics10091122

Chicago/Turabian Style

D’Arcy, Nikki, Diane Ashiru-Oredope, Omotayo Olaoye, Daniel Afriyie, Zainab Akello, Daniel Ankrah, Derrick Mawuena Asima, David C. Banda, Scott Barrett, Claire Brandish, and et al. 2021. "Antibiotic Prescribing Patterns in Ghana, Uganda, Zambia and Tanzania Hospitals: Results from the Global Point Prevalence Survey (G-PPS) on Antimicrobial Use and Stewardship Interventions Implemented" Antibiotics 10, no. 9: 1122. https://doi.org/10.3390/antibiotics10091122

APA Style

D’Arcy, N., Ashiru-Oredope, D., Olaoye, O., Afriyie, D., Akello, Z., Ankrah, D., Asima, D. M., Banda, D. C., Barrett, S., Brandish, C., Brayson, J., Benedict, P., Dodoo, C. C., Garraghan, F., Hoyelah, J., Sr., Jani, Y., Kitutu, F. E., Kizito, I. M., Labi, A.-K., ... Versporten, A. (2021). Antibiotic Prescribing Patterns in Ghana, Uganda, Zambia and Tanzania Hospitals: Results from the Global Point Prevalence Survey (G-PPS) on Antimicrobial Use and Stewardship Interventions Implemented. Antibiotics, 10(9), 1122. https://doi.org/10.3390/antibiotics10091122

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