In Vitro Activities of Ceftobiprole, Dalbavancin, Tedizolid and Comparators against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus Associated with Skin and Soft Tissue Infections
Abstract
:1. Introduction
2. Results
3. Discussion
4. Material and Methods
4.1. Study Design, Setting and Patient Population
4.2. Bacterial Isolates
4.3. Antimicrobial Susceptibility Testing
4.4. Statistics
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Antibiotic | Antibiotic Class | Mechanism of Action | Type of Activity | Antimicrobial Spectrum | Date of Approval | Reference |
---|---|---|---|---|---|---|
Dalbavancin | Lipoglycopeptide | Inhibits bacterial cell wall synthesis by binding to D-alanyl-D-alanyl residue on growing peptidoglycan | Bactericidal | MSSA, MRSA, VISA, S. pyogenes, S. agalactiae, S. anginosus, S. faecalis vancomycin-susceptible | FDA: May 2014 | [19,20,21] |
Telavancin | Lipoglycopeptide | Inhibits peptidoglycan cell wall synthesis and disrupts bacterial cell membrane integrity | Bactericidal | MSSA, MRSA, hVISA, VISA, S. pyogenes, S. agalactiae, S. anginosus group, PRSP, VSE | FDA: September 2009 | [20] |
Oritavancin | Lipoglycopeptide | Inhibits peptidoglycan cell wall synthesis and disrupts bacterial cell membrane integrity | Bactericidal | MSSA, MRSA, VISA, VRSA, VRE | FDA: August 2014 EMA: March 2015 | [20] |
Ceftaroline | Fifth–generation cephalosporin | Inhibits cell wall synthesis by binding to penicillin-binding proteins (PBPs) | Bactericidal | MSSA, MRSA, VRSA, S. pyo-genes, S. agalactiae, S. pneumoniae, E. faecalis, Gram-negative bacteria (except Pseudomonas and ESBL Enterobacterales) | FDA: October 2010 EMA: August 2012 | [22] |
Cefobiprole | Fifth–generation cephalosporin | Inhibits cell wall synthesis by binding to penicillin-binding proteins (PBPs) | Bactericidal | MSSA, MRSA, ampicillin-susceptible enterococci, PRSP, Gram-negative bacteria (except pathogens producing ESBLs) | EMA: October 2013 | [23] |
Tedizolid | Second- generation oxazolidinone | Inhibits bacterial protein synthesis by binding to the 50 S ribosomal subunit | Bacteriostatic | MSSA, MRSA, CoNS, S. pyogenes, S. agalactiae, S. anginosus group, VSE, VRE | FDA: June 2014 EMA: March 2015 | [24] |
Omadacycline | New-generation Broad-spectrum aminomethylcycline | Inhibits bacterial protein synthesis by binding to the 30 S ribosomal subunit | Bacteriostatic | MSSA, MRSA, PRSP, VSE, VRE | FDA: October 2018 | [25] |
Delafloxacin | New-generation anionic fluoroquinolone | Inhibits the activities of both bacterial topoisomerase IV and DNA gyrase | Bactericidal | MRSA, MSSA, CoNS, S. pyogenes, S. agalactiae, S. anginosus group, S. pneumoniae, E. coli, K. pneumoniae, E. cloacae, P. aeruginosa | FDA: June 2017 | [26] |
Antibiotic | MIC50 | MIC90 | Range | S% |
---|---|---|---|---|
Vancomycin | 1 | 2 | 0.38–2 | 100 |
Daptomycin | 0.5 | 1 | 0.125–1.5 | 98.4 |
Ceftobiprole | 0.38 | 1 | 0.064–1.5 | 100 |
Linezolid | 0.38 | 1 | 0.125–2 | 100 |
Tedizolid | 0.25 | 0.38 | 0.094–0.5 | 100 |
Dalbavancin | 0.064 | 0.094 | 0.008–0.125 | 100 |
Number of Isolates Inhibited at (mg/L) | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Antibiotic | 0.008 | 0.023 | 0.032 | 0.047 | 0.064 | 0.094 | 0.125 | 0.19 | 0.25 | 0.38 | 0.5 | 0.75 | 1 | 1.5 | 2 |
Vancomycin | 2 | 5 | 16 | 43 | 36 | 22 | |||||||||
Daptomycin | 2 | 4 | 24 | 12 | 20 | 12 | 48 | 2 | |||||||
Ceftobiprole | 4 | 5 | 12 | 19 | 28 | 28 | 12 | 4 | 12 | ||||||
Linezolid | 10 | 10 | 36 | 20 | 8 | 4 | 30 | 2 | 4 | ||||||
Tedizolid | 4 | 28 | 28 | 30 | 22 | 12 | |||||||||
Dalbavancin | 2 | 14 | 8 | 30 | 40 | 20 | 10 |
No. | ||
---|---|---|
Resistance to three indicated classes | 26 | |
1 | P-OX, FA, MU | 10 |
2 | P-OX, E, CM | 6 |
3 | P-OX, FA, LE | 4 |
4 | P-OX, GM, FA | 2 |
5 | P-OX, E, MU | 2 |
6 | P-OX, FA, TE | 2 |
Resistance to four indicated classes | 35 | |
7 | P-OX, E, CM, LE | 12 |
8 | P-OX, E, CM, TE | 9 |
9 | P-OX, FA, GM, TE | 8 |
10 | P-OX, CM, FA, MU | 2 |
11 | P-OX, FA, MU, LE | 2 |
12 | P-OX, E, FA, LE | 2 |
Resistance to five indicated classes | 16 | |
13 | P-OX, E, CM, FA, LE | 8 |
14 | P-OX, E, CM, FA, TE | 6 |
15 | P-OX, CM, TE, LE, SXT | 2 |
Resistance to six indicated classes | 12 | |
16 | P-OX, E, CM, FA, LE, TE | 8 |
17 | P-OX, E, CM, FA, LE, MU | 4 |
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Maraki, S.; Mavromanolaki, V.E.; Stafylaki, D.; Iliaki-Giannakoudaki, E.; Hamilos, G. In Vitro Activities of Ceftobiprole, Dalbavancin, Tedizolid and Comparators against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus Associated with Skin and Soft Tissue Infections. Antibiotics 2023, 12, 900. https://doi.org/10.3390/antibiotics12050900
Maraki S, Mavromanolaki VE, Stafylaki D, Iliaki-Giannakoudaki E, Hamilos G. In Vitro Activities of Ceftobiprole, Dalbavancin, Tedizolid and Comparators against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus Associated with Skin and Soft Tissue Infections. Antibiotics. 2023; 12(5):900. https://doi.org/10.3390/antibiotics12050900
Chicago/Turabian StyleMaraki, Sofia, Viktoria Eirini Mavromanolaki, Dimitra Stafylaki, Evangelia Iliaki-Giannakoudaki, and George Hamilos. 2023. "In Vitro Activities of Ceftobiprole, Dalbavancin, Tedizolid and Comparators against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus Associated with Skin and Soft Tissue Infections" Antibiotics 12, no. 5: 900. https://doi.org/10.3390/antibiotics12050900