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Open AccessArticle
Matrix Metalloproteinase 9 (MMP-9) and Interleukin-8 (IL-8) in Gingival Crevicular Fluid After Minimally Invasive Periodontal Surgery With or Without Er:YAG and Nd:YAG Laser Application
by
Ewa Dolińska
Ewa Dolińska 1,*,
Anna Skurska
Anna Skurska 1,2,
Violetta Dymicka-Piekarska
Violetta Dymicka-Piekarska 3,
Robert Milewski
Robert Milewski 4 and
Małgorzata Pietruska
Małgorzata Pietruska 1
1
Department of Periodontal and Oral Mucosa Diseases, Medical University of Bialystok, ul. Waszyngtona 13, 15-269 Bialystok, Poland
2
Department of Integrated Dentistry, Medical University of Bialystok, ul. M. Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland
3
Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, ul. Waszyngtona 15, 15-269 Bialystok, Poland
4
Department of Biostatistics and Medical Informatics, Medical University of Bialystok, ul. Szpitalna 37, 15-295 Bialystok, Poland
*
Author to whom correspondence should be addressed.
Antibiotics 2024, 13(8), 704; https://doi.org/10.3390/antibiotics13080704 (registering DOI)
Submission received: 16 June 2024
/
Revised: 23 July 2024
/
Accepted: 24 July 2024
/
Published: 27 July 2024
Abstract
Background: This study aimed to evaluate alterations in the concentrations of matrix metalloproteinase-9 (MMP-9) and interleukin-8 (IL-8) within gingival crevicular fluid (GCF) extracted from the intrabony periodontal defect site before and after minimally invasive regenerative surgery, with or without supplemental laser application. The surgical procedure was performed using the modified minimally invasive surgical technique (M-MIST). Methods: Thirty-eight patients, each presenting with a single vertical defect, were randomly assigned to either the test (M-MIST + Er:YAG + Nd:YAG) or the control group (M-MIST). IL-8 and MMP-9 levels (primary outcomes of the study) were assessed prior to therapy, after 2 and 4 weeks, and 6 months following the surgical procedure by means of dedicated ELISA kits. Results: Both procedures were clinically effective as evidenced by probing depth (PD) reduction and clinical attachment level (CAL) gain at the 6-month follow-up. No statistical differences were observed in the levels of MMP-9 and IL-8 between the groups at any time point assessed. The changes in the level of MMP-9 and IL-8 over time were not statistically significant in any group. IL-8 was positively correlated with MMP-9 in the control group throughout the study and in the test group 2 weeks and 6 months post-op. Conclusions: Within the limitations of this study, the additional application of Er:YAG + Nd:YAG lasers alongside the M-MIST procedure did not enhance the clinical and biochemical treatment outcomes compared to M-MIST alone.
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MDPI and ACS Style
Dolińska, E.; Skurska, A.; Dymicka-Piekarska, V.; Milewski, R.; Pietruska, M.
Matrix Metalloproteinase 9 (MMP-9) and Interleukin-8 (IL-8) in Gingival Crevicular Fluid After Minimally Invasive Periodontal Surgery With or Without Er:YAG and Nd:YAG Laser Application. Antibiotics 2024, 13, 704.
https://doi.org/10.3390/antibiotics13080704
AMA Style
Dolińska E, Skurska A, Dymicka-Piekarska V, Milewski R, Pietruska M.
Matrix Metalloproteinase 9 (MMP-9) and Interleukin-8 (IL-8) in Gingival Crevicular Fluid After Minimally Invasive Periodontal Surgery With or Without Er:YAG and Nd:YAG Laser Application. Antibiotics. 2024; 13(8):704.
https://doi.org/10.3390/antibiotics13080704
Chicago/Turabian Style
Dolińska, Ewa, Anna Skurska, Violetta Dymicka-Piekarska, Robert Milewski, and Małgorzata Pietruska.
2024. "Matrix Metalloproteinase 9 (MMP-9) and Interleukin-8 (IL-8) in Gingival Crevicular Fluid After Minimally Invasive Periodontal Surgery With or Without Er:YAG and Nd:YAG Laser Application" Antibiotics 13, no. 8: 704.
https://doi.org/10.3390/antibiotics13080704
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