Novel Antimicrobial Agents Based on Zinc-Doped Hydroxyapatite Loaded with Tetracycline
Abstract
:1. Introduction
2. Results and Discussions
3. Materials and Methods
3.1. Materials
3.2. Development of Zinc-Doped Hydroxyapatite Enriched with Tetracycline
3.3. X-ray Diffraction (XRD)
3.4. Fourier Transform Infrared Spectroscopy (FTIR)
3.5. X-ray Photoelectron Spectroscopy (XPS)
3.6. Transmission Electron Microscopy (TEM)
3.7. Scanning Electron Microscopy (SEM)
3.8. Hemolysis Assay
3.9. MTT Assay
3.10. Lactate Dehydrogenase (LDH) Release Measurement
3.11. In Vitro Antimicrobial Activity
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sample | Ca | P | O | Zn | N | Cl |
---|---|---|---|---|---|---|
ZnHAp | 16.9 | 10.68 | 71.49 | 0.93 | - | - |
ZnHApTe | 20.18 | 12.65 | 51.6 | 0.92 | 0.95 | 13.7 |
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Iconaru, S.L.; Predoi, D.; Ciobanu, C.S.; Negrila, C.C.; Trusca, R.; Raaen, S.; Rokosz, K.; Ghegoiu, L.; Badea, M.L.; Cimpeanu, C. Novel Antimicrobial Agents Based on Zinc-Doped Hydroxyapatite Loaded with Tetracycline. Antibiotics 2024, 13, 803. https://doi.org/10.3390/antibiotics13090803
Iconaru SL, Predoi D, Ciobanu CS, Negrila CC, Trusca R, Raaen S, Rokosz K, Ghegoiu L, Badea ML, Cimpeanu C. Novel Antimicrobial Agents Based on Zinc-Doped Hydroxyapatite Loaded with Tetracycline. Antibiotics. 2024; 13(9):803. https://doi.org/10.3390/antibiotics13090803
Chicago/Turabian StyleIconaru, Simona Liliana, Daniela Predoi, Carmen Steluta Ciobanu, Catalin Constantin Negrila, Roxana Trusca, Steinar Raaen, Krzysztof Rokosz, Liliana Ghegoiu, Monica Luminita Badea, and Carmen Cimpeanu. 2024. "Novel Antimicrobial Agents Based on Zinc-Doped Hydroxyapatite Loaded with Tetracycline" Antibiotics 13, no. 9: 803. https://doi.org/10.3390/antibiotics13090803