Is Taurolidine Irrigation Effective in Preventing Surgical Site Infection during Fracture Surgery?
Abstract
:1. Introduction
2. Results
2.1. Patient Demographics
2.2. Infection Outcomes
2.3. Infection Analysis and Taurolidine Irrigation Impact
3. Discussion
4. Materials and Methods
4.1. Surgical Procedures
4.2. Postoperative Antibiotics and Major Infection Management
4.3. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameter | Taurolidine Irrigation Group | NS Irrigation Group | p-Value | |
---|---|---|---|---|
No. subjects (Male/Female) | 328 | 360 | ||
Laterality (Right/Left) | 153/175 | 188/172 | 0.148 | |
Age at operation (years) | 47.4 ± 17.1 | 45.4 ± 16.2 | 0.117 | |
Fracture classification | ||||
Single malleolar | 198 | 198 | ||
Bimalleolar | 38 | 34 | ||
Trimalleolar | 92 | 128 | ||
Open fracture | 11 | 4 | 0.065 | |
OP time (min) | 42.5 ± 14.7 | 41.8 ± 24.9 | 0.658 | |
DM patients | 26 | 13 | 0.020 | |
Minor infection | 11 (3.4%) | 35 (9.7%) | <0.001 | |
Major infection | 4 (1.2%) | 0 (0%) | 0.051 |
Variable | Subgroup | N | Case N | Univariable Analysis | Multivariable Analysis | ||
---|---|---|---|---|---|---|---|
OR (95% CI) | p-Value | OR (95% CI) | p-Value | ||||
Taurolidine use | 688 | 46 | |||||
NS irrigation | 360 | 35 | Ref. | Ref. | |||
Taurolidine irrigation | 328 | 11 | 0.322 (0.161–0.646) | 0.001 | 0.410 (0.186–0.907) | 0.028 | |
Sex | 688 | 46 | |||||
Male | 364 | 28 | Ref. | ||||
Female | 324 | 18 | 0.706 (0.383–1.302) | 0.265 | 0.741 (0.392–1.401) | 0.356 | |
Age | 688 | 46 | 0.990 (0.974–1.006) | 0.215 | 0.994 (0.977–1.012) | 0.531 | |
OP time | 688 | 46 | 0.979 (0.962–0.997) | 0.019 | 0.990 (0.972–1.008) | 0.281 | |
Open fracture | 688 | 46 | |||||
Open | 14 | 1 | Ref. | Ref. | |||
Closed | 674 | 45 | 0.930 (0.119–7.271) | 0.945 | 0.564 (0.065–4.857) | 0.602 |
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Dakhode, S.Y.; Kim, W.S.; Kim, H.J.; Lee, S.Y. Is Taurolidine Irrigation Effective in Preventing Surgical Site Infection during Fracture Surgery? Antibiotics 2024, 13, 841. https://doi.org/10.3390/antibiotics13090841
Dakhode SY, Kim WS, Kim HJ, Lee SY. Is Taurolidine Irrigation Effective in Preventing Surgical Site Infection during Fracture Surgery? Antibiotics. 2024; 13(9):841. https://doi.org/10.3390/antibiotics13090841
Chicago/Turabian StyleDakhode, Shubham Yashwant, Woo Sub Kim, Hyun Jin Kim, and Seung Yeol Lee. 2024. "Is Taurolidine Irrigation Effective in Preventing Surgical Site Infection during Fracture Surgery?" Antibiotics 13, no. 9: 841. https://doi.org/10.3390/antibiotics13090841