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Antibiotics
Volume 7
Issue 2
10.3390/antibiotics7020046
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Review

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

by
Laís Salomão Arias
1,
Juliano Pelim Pessan
1,
Ana Paula Miranda Vieira
1,
Taynara Maria Toito de Lima
2,
Alberto Carlos Botazzo Delbem
1 and
Douglas Roberto Monteiro
2,*
1
Department of Pediatric Dentistry and Public Health, School of Dentistry, Araçatuba, São Paulo State University (Unesp), 16015-050 Araçatuba/São Paulo, Brazil
2
Graduate Program in Dentistry (GPD-Master’s Degree), University of Western São Paulo (UNOESTE), 19050-920 Presidente Prudente/São Paulo, Brazil
*
Author to whom correspondence should be addressed.
Antibiotics 2018, 7(2), 46; https://doi.org/10.3390/antibiotics7020046
Submission received: 16 April 2018 / Revised: 1 June 2018 / Accepted: 7 June 2018 / Published: 9 June 2018
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Abstract

Medical applications and biotechnological advances, including magnetic resonance imaging, cell separation and detection, tissue repair, magnetic hyperthermia and drug delivery, have strongly benefited from employing iron oxide nanoparticles (IONPs) due to their remarkable properties, such as superparamagnetism, size and possibility of receiving a biocompatible coating. Ongoing research efforts focus on reducing drug concentration, toxicity, and other side effects, while increasing efficacy of IONPs-based treatments. This review highlights the methods of synthesis and presents the most recent reports in the literature regarding advances in drug delivery using IONPs-based systems, as well as their antimicrobial activity against different microorganisms. Furthermore, the toxicity of IONPs alone and constituting nanosystems is also addressed.
Keywords: biotechnology; drug delivery; iron oxide nanoparticles; magnetic nanoparticles biotechnology; drug delivery; iron oxide nanoparticles; magnetic nanoparticles

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MDPI and ACS Style

Arias, L.S.; Pessan, J.P.; Vieira, A.P.M.; Lima, T.M.T.d.; Delbem, A.C.B.; Monteiro, D.R. Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity. Antibiotics 2018, 7, 46. https://doi.org/10.3390/antibiotics7020046

AMA Style

Arias LS, Pessan JP, Vieira APM, Lima TMTd, Delbem ACB, Monteiro DR. Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity. Antibiotics. 2018; 7(2):46. https://doi.org/10.3390/antibiotics7020046

Chicago/Turabian Style

Arias, Laís Salomão, Juliano Pelim Pessan, Ana Paula Miranda Vieira, Taynara Maria Toito de Lima, Alberto Carlos Botazzo Delbem, and Douglas Roberto Monteiro. 2018. "Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity" Antibiotics 7, no. 2: 46. https://doi.org/10.3390/antibiotics7020046

APA Style

Arias, L. S., Pessan, J. P., Vieira, A. P. M., Lima, T. M. T. d., Delbem, A. C. B., & Monteiro, D. R. (2018). Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity. Antibiotics, 7(2), 46. https://doi.org/10.3390/antibiotics7020046

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