Production of β-Lactamase Inhibitors by Streptomyces Species
Abstract
:1. Introduction
2. Antibiotic Resistance
3. Producers of β-Lactamases
4. Inhibitors of β-Lactamases
5. Producers of β-Lactamases Inhibitors
5.1. Natural Microorganisms
5.2. Genetically-Modified Microorganisms
6. Production of β-Lactamase Inhibitors
6.1. Biosynthesis of Clavulanic Acid
6.2. Production Process
6.2.1. Carbon Sources
6.2.2. Nitrogen Sources
6.2.3. Amino Acids as Supplements in Basal Medium
6.2.4. Salts in Basal Medium
6.2.5. Effect of pH
6.2.6. Extractive Fermentation of Clavulanic Acid
7. β-Lactamase Inhibitors in Clinical Practice
8. Commercial Use
9. Future Perspectives
10. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Functional Group According Bush, Jacoby, and Medeiros * | Ambler Class * | Hydrolyzed β-Lactam Antibiotics | |
---|---|---|---|
1 | C | Cephalosporins, benzylpenicillin, cephamycins | |
1e | C | Ceftazidime and often other oxyimino-β-lactams | |
2 | 2a | A | Benzylpenicillin |
2b | A | Benzylpenicillin and cephalosporins | |
2be | A | Cefotaxime, ceftazidime, ceftriaxone, cefepime, aztreonam | |
2br | A | Resistance to clavulanic acid, sulbactam, and tazobactam | |
2ber | A | Oxyimino-β-lactams combined with resistance to clavulanic acid, sulbactam, and tazobactam | |
2c | A | Carbenicillin | |
2ce | A | Carbenicillin, cefepime, and cefpirome | |
2d | D | Cloxacillin or oxacillin | |
2de | D | Cloxacillin or oxacillin, and oxyimino-β-lactams | |
2df | D | Cloxacillin or oxacillin and carbapenems | |
2e | A | Cephalosporins inhibited by clavulanic acid | |
2f | A | Carbapenems, oxyimino-β-lactams, cephamycins | |
3 | B | Carbapenems | |
4 | Unknown | Carbapenems |
Genetic Method | Secondary Metabolite |
---|---|
Protoplast fusion | Penicillin G, cephalosporin C, cephamycin C, clavulanic acid, indolizomycin, rifamycins |
Metabolic engineering | Antibiotics (penicillin G, cephalosporin C, cephamycin C, clavulanic acid, semisynthetic cephalosporins) |
Transposition | Daptomycin, tylosin |
Combinatorial biosynthesis | Erythromycins, tetracenomycins, tylosin, spiramycins |
Genome mining | Echinosporamicin-type antibiotics, antifungal compounds (ECO-02301), and so on |
β–Lactamase Inhibitor | β–Lactam Antibiotic | Development Status | References |
---|---|---|---|
Clavulanic acid | Amoxicillin | Approved by FDA, EMA | [139] |
Sulbactam | Ampicillin | Approved by FDA, EMA | [140] |
ETX2514 | Phase 1 trials completed in 2017 | [34] | |
Tazobactam | Piperacillin | Approved by FDA, EMA | [141] |
Ceftolozane | Approved in 2014 by FDA and in 2015 by EMA | [34,142,143,144,145,146] | |
Cefepime | Used in Asia | [147] | |
Avibactam | Ceftazidime | Approved in 2015 by FDA and in 2016 by EMA | [34,148,149,150,151,152,153,154,155,156,157,158,159] |
Aztreonam | Phase 2 in progress | [149,153,160,161] | |
Ceftaroline | Phase 2 in progress | [149,159,162,163] | |
Relebactam (MK7655) | Imipenem (+ cilastatin) | Phase 3, cUTI (in progress) Phase 2 cIAI (completed) | [164,165] |
Vaborbactam (RPX7009) | Meropenem | Approved in 2017 by FDA | [34,166] |
AAI101 | Cefepime | Phase 2 initiated in 2017 | [34,167,168] |
RG6080 (OP0595, FPI-1459) | Unknown | Phase 1 complete | [165] |
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Viana Marques, D.D.A.; Machado, S.E.F.; Ebinuma, V.C.S.; Duarte, C.D.A.L.; Converti, A.; Porto, A.L.F. Production of β-Lactamase Inhibitors by Streptomyces Species. Antibiotics 2018, 7, 61. https://doi.org/10.3390/antibiotics7030061
Viana Marques DDA, Machado SEF, Ebinuma VCS, Duarte CDAL, Converti A, Porto ALF. Production of β-Lactamase Inhibitors by Streptomyces Species. Antibiotics. 2018; 7(3):61. https://doi.org/10.3390/antibiotics7030061
Chicago/Turabian StyleViana Marques, Daniela De Araújo, Suellen Emilliany Feitosa Machado, Valéria Carvalho Santos Ebinuma, Carolina De Albuquerque Lima Duarte, Attilio Converti, and Ana Lúcia Figueiredo Porto. 2018. "Production of β-Lactamase Inhibitors by Streptomyces Species" Antibiotics 7, no. 3: 61. https://doi.org/10.3390/antibiotics7030061
APA StyleViana Marques, D. D. A., Machado, S. E. F., Ebinuma, V. C. S., Duarte, C. D. A. L., Converti, A., & Porto, A. L. F. (2018). Production of β-Lactamase Inhibitors by Streptomyces Species. Antibiotics, 7(3), 61. https://doi.org/10.3390/antibiotics7030061