Antibiotic Discovery: Where Have We Come from, Where Do We Go?
Abstract
:1. Introduction—The Desperate Need for New Antibiotics
2. The Birth of Antimicrobial Chemotherapy
3. Towards the Golden Era: Waksman Platform
4. Onto the Medicinal Chemistry Era: Semi-Synthesis
5. From the Ground Up: Fully Synthetic Antibiotics
6. Advent of Genomics: Target-Based Screening
7. Reverse Genomics: Revival of Cell-Based Screening
8. Post-Genomics: Transcriptomics, Proteomics and Lipidomics
9. Post-Genomics: From Metabolomics towards Meta-omics
10. Conclusions
Supplementary Materials
Supplementary File 1Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Subclasses | Examples of Marketed Antibiotics |
---|---|
Penicillins | Penicillin G, Penicillin V, Ampicillin, Amoxicillin, Bacampicillin, Cloxacillinm, Floxacillin, Mezlocillin, Nafcillin, Oxacillin, Methicillin a, Dicloxacillin a, Carbenicillin b, Idanyl b, Piperacillin b, Ticarcillin b |
Cephalosporins | Cefalothin c, Cephradinea c, Cefadroxyl c, Cefazolin c, Cephalexin c, Cefuroxine d, Cefaclor d, Cefotetam d, Cefmetazole d, Cefonicid d, Cefixime e, Ceftibuten e, Cefizoxime e, Ceftriaxone e, Cefamandol e, Cefoperazone e, Cefotaxime e, Proxetil e, Cefprozil e, Ceftazidime e, Cefuroxime Axetil e, Cefpodexime e, Cefepime f, Ceftobiprole g |
Other Minor Subclasses | Flomoxef h, Latamoxef h, Cefoxitin i, Loracarbef j, Imipenem j, Meropenem j, Panipenem j, Aztreonam k, Carumonam k |
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Ribeiro da Cunha, B.; Fonseca, L.P.; Calado, C.R.C. Antibiotic Discovery: Where Have We Come from, Where Do We Go? Antibiotics 2019, 8, 45. https://doi.org/10.3390/antibiotics8020045
Ribeiro da Cunha B, Fonseca LP, Calado CRC. Antibiotic Discovery: Where Have We Come from, Where Do We Go? Antibiotics. 2019; 8(2):45. https://doi.org/10.3390/antibiotics8020045
Chicago/Turabian StyleRibeiro da Cunha, Bernardo, Luís P. Fonseca, and Cecília R. C. Calado. 2019. "Antibiotic Discovery: Where Have We Come from, Where Do We Go?" Antibiotics 8, no. 2: 45. https://doi.org/10.3390/antibiotics8020045
APA StyleRibeiro da Cunha, B., Fonseca, L. P., & Calado, C. R. C. (2019). Antibiotic Discovery: Where Have We Come from, Where Do We Go? Antibiotics, 8(2), 45. https://doi.org/10.3390/antibiotics8020045