Strategies to Combat Multidrug-Resistant and Persistent Infectious Diseases
Abstract
:1. Introduction
2. New Anti-Infectious Treatments against MDR and Persistent Bacteria
2.1. Antimicrobial Peptides (AMPs)
2.2. Anti-Virulence Compounds
2.3. Phage Therapy Alone or in Combination with Antibiotics to Treat MDR and Persistent Bacteria
2.4. New Molecules
3. Repurposing Treatments against MDR and Persistent Bacteria
3.1. Anti-Inflammatories as Antibacterial Agents
3.2. Anti-Psychotics
3.3. Anti-Helminthic Drugs
3.4. Anti-Cancerous Drugs as Antibacterials
3.5. Statins
4. Discussion
5. Conclusions
Funding
Conflicts of Interest
References
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Name of Drug | Type of Drug | Active against | Mechanism of Action | Reference |
---|---|---|---|---|
P5 and P9 | AMPs | MRSA | Inhibition of biofilm, disruption of membrane integrity, downregulation of virulence genes | [32] |
Cationic peptides | Inhibition of TCS vanRS | VRE | Restoration of vancomycin activity | [33] |
Inhibitors of AcrAB–TolC | Inhibition of AcrAB–TolC | MDR Escherichia coli | Restoration of antibiotic activity, induction of spontaneous mutations, inhibition of DNA mismatch repair system | [37] |
Cocktail of 9 lytic phages | Lytic phages | MDR Acinetobacter baumannii | Lysis of MDR A. baumannii cells | [43] |
Ab105-2phiΔCI | Engineered phage | MDR A. baumannii | Lysis of MDR A. baumannii cells, synergy with carbapenems | [49] |
LysAB2 | Endolysin from a phage | MRSA | Bactericidal activity against MRSA, A. baumannii, and E. coli | [54] |
Cbf-K16 | AMP anti-inflammatory | Clarithromycin and amoxicillin-resistant Helicobacter pylori SS1 | Inhibition of IL-8, downregulation of virulence and adhesion genes | [61] |
5-Fluorouracil and 6-thioguanine | Anti-cancerous | A. baumannii | Pirimidin and purin analogues | [73] |
Gallium | Anti-cancerous | MDR ESKAPE | Competition with Fe+3 | [76] |
Clomiphene | Anti-cancerous (SERM) | MRSA | Inhibition of UPPS, synergy with β-lactams | [79] |
Simvastatin | Statin | MRSA skin infections | Anti-biofilm activity against staphylococcal biofilms in vivo | [84] |
Name of Drug | Type of Drug | Active against | Mechanism of Action | Reference (PMID) |
---|---|---|---|---|
P2* (Defensin-like peptide) | Permeabilizer | Staphylococcus aureus | Binding to DNA, biofilm inhibition | [31] |
BF8* | QS inhibitor | E. coli | Disruption of E. coli biofilm, restoration of ofloxacin activity | [34] |
ADEP4 | ClpP activator | S. aureus | Degradation of hundreds of proteins | [35] |
M64 | QS inhibitor | Pseudomonas aeruginosa | Inhibition of PqsR, down-regulation of virulence genes | [36] |
Cocktail of 6 lytic phages | Lytic phages | Recurrent P. aeruginosa | Lysis of P. aeruginosa bacterial cells | [44] |
phi11 endolysin | Endolysin from a phage | S. aureus | Disruption of S. aureus biofilms and bactericidal activity | [50] |
CHAP(K) | Endolysin from a phage | S. aureus | Removal of staphylococcal biofilms | [51] |
PlyC | Endolysin from a phage | Streptococcus spp. | Removal of streptococcal biofilms | [52] |
PlyE146 | Endolysin from a phage | E. coli, P. aeruginosa, and A. baumannii | Disruption of E. coli, P. aeruginosa and A. baumannii biofilms | [53] |
CD437* and CD1530* | Retinoids (analogues of vitamin A) | S. aureus | Membrane disruption | [55] |
Cisplatin | Anti-cancerous | E. coli K-12, S. aureus, P. aeruginosa | Forms intra-strand DNA crosslinks | [78] |
Mitomycin C | Anti-cancerous | Broad range of persisters | Forms inter-strand DNA crosslinks | [78] |
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Pacios, O.; Blasco, L.; Bleriot, I.; Fernandez-Garcia, L.; González Bardanca, M.; Ambroa, A.; López, M.; Bou, G.; Tomás, M. Strategies to Combat Multidrug-Resistant and Persistent Infectious Diseases. Antibiotics 2020, 9, 65. https://doi.org/10.3390/antibiotics9020065
Pacios O, Blasco L, Bleriot I, Fernandez-Garcia L, González Bardanca M, Ambroa A, López M, Bou G, Tomás M. Strategies to Combat Multidrug-Resistant and Persistent Infectious Diseases. Antibiotics. 2020; 9(2):65. https://doi.org/10.3390/antibiotics9020065
Chicago/Turabian StylePacios, Olga, Lucia Blasco, Inès Bleriot, Laura Fernandez-Garcia, Mónica González Bardanca, Antón Ambroa, María López, German Bou, and Maria Tomás. 2020. "Strategies to Combat Multidrug-Resistant and Persistent Infectious Diseases" Antibiotics 9, no. 2: 65. https://doi.org/10.3390/antibiotics9020065
APA StylePacios, O., Blasco, L., Bleriot, I., Fernandez-Garcia, L., González Bardanca, M., Ambroa, A., López, M., Bou, G., & Tomás, M. (2020). Strategies to Combat Multidrug-Resistant and Persistent Infectious Diseases. Antibiotics, 9(2), 65. https://doi.org/10.3390/antibiotics9020065