Is Only Clarithromycin Susceptibility Important for the Successful Eradication of Helicobacter pylori?
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Population
2.2. Data Collection
2.3. Isolation of H. pylori Strains and Growth Conditions
2.4. Antimicrobial Susceptibility Testing
2.5. Eradication Therapy for H. pylori
2.6. Statistical Analysis
3. Results
3.1. Flow Chart and Baseline Characteristics
3.2. Results of Antimicrobial Susceptibility Testing
3.3. Eradication Rate for H. pylori
3.4. Comparison between Antimicrobial Susceptibility Testing and Eradication Rate
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
Appendix A
Antimicrobial Susceptibility Testing | Number (%) of Successful Eradications | ||
---|---|---|---|
Clarithromycin | Amoxicillin | Metronidazole | |
S | S | S | 23/24 (95.8) |
S | R | S | 3/3 (100.0) |
S | S | R | 8/9 (88.9) |
S | R | R | 0/0 |
R | S | S | 2/4 (50.0) |
R | R | S | 1/2 (50.0) |
R | S | R | 0/0 |
R | R | R | 0/1 (0.0) |
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Characteristics | All Patients (n = 247) |
---|---|
Age (years, mean ± SD) | 55.4 ± 11.8 |
Male (n, %) | 106 (42.9) |
Height (cm, mean ± SD) | 163.2 ± 8.4 |
Weight (kg, mean ± SD) | 64.1 ± 12.2 |
BMI (kg/m2, mean ± SD) | 23.3 ± 3.4 |
Current smoker (n, %) | 45 (18.2) |
Alcohol history (n, %) | 103 (41.7) |
Diabetes mellitus (n, %) | 50 (20.2) |
Hypertension (n, %) | 24 (9.7) |
RUT, positive (n, %) | 223 (90.3) |
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Kim, Y.M.; Lee, K.H.; Kim, J.-H.; Park, S.Y.; Song, Y.G.; Jeon, S.Y.; Park, H. Is Only Clarithromycin Susceptibility Important for the Successful Eradication of Helicobacter pylori? Antibiotics 2020, 9, 589. https://doi.org/10.3390/antibiotics9090589
Kim YM, Lee KH, Kim J-H, Park SY, Song YG, Jeon SY, Park H. Is Only Clarithromycin Susceptibility Important for the Successful Eradication of Helicobacter pylori? Antibiotics. 2020; 9(9):589. https://doi.org/10.3390/antibiotics9090589
Chicago/Turabian StyleKim, Young Min, Kyoung Hwa Lee, Jie-Hyun Kim, Soon Young Park, Young Goo Song, Se Yeon Jeon, and Hyojin Park. 2020. "Is Only Clarithromycin Susceptibility Important for the Successful Eradication of Helicobacter pylori?" Antibiotics 9, no. 9: 589. https://doi.org/10.3390/antibiotics9090589