Coated Biodegradable Zinc Lithium Alloys: Development and Characterization of Co-Doped Strontium Copper Tricalcium Phosphate Coating for Antimicrobial Applications
Abstract
:1. Introduction
2. Materials and Methods
2.1. Zn-Li Alloy Preparation
2.2. Synthesis of Bulk Target Material—Double Substituted Sr- and Cu- Tricalcium Phosphate (SrCu-TCP)
2.3. Pulsed Laser Deposition of Coatings
2.4. Physico-Chemical Characterization of Coatings
2.5. Microbiology Tests
2.6. Statistical Analysis
3. Results and Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Peak Number | β-TCP 2θ Peak Position (°) | SrCu-TCP 2θ Peak Position (°) | Δ2θ | hkl Miller Index [64] | R.I.% |
---|---|---|---|---|---|
1 | 13.52 | 13.56 | 0.04 | 1 0 4 | 16 |
2 | 16.88 | 16.92 | 0.04 | 1 1 0 | 20 |
3 | 21.76 | 21.80 | 0.04 | 0 2 4 | 16 |
4 | 25.68 | 25.68 | 0.00 | 1 0 10 | 25 |
5 | 26.40 | 26.52 | 0.12 | 1 2 2 | 10 |
6 | 27.72 | 27.80 | 0.08 | 2 1 4 | 55 |
7 | 29.56 | 29.68 | 0.12 | 3 0 0 | 16 |
8 | 30.96 | 31.00 | 0.04 | 0 2 10 | 100 |
9 | 32.36 | 32.48 | 0.12 | 1 2 8 | 20 |
10 | 34.28 | 34.44 | 0.16 | 2 2 0 | 65 |
11 | 35.04 | 35.22 | 0.18 | 2 2 3 | 8 |
12 | 35.52 | 35.60 | 0.08 | 2 1 10 | 12 |
13 | 37.24 | 37.40 | 0.16 | 1 2 11 | 10 |
14 | 39.76 | 39.76 | 0.00 | 1 0 16 | 10 |
15 | 41.00 | 41.18 | 0.18 | 4 0 4 | 14 |
16 | 41.60 | 41.68 | 0.08 | 3 0 12 | 12 |
17 | 46.88 | 47.08 | 0.20 | 4 0 10 | 20 |
18 | 47.88 | 48.12 | 0.24 | 2 3 8 | 16 |
19 | 48.28 | 48.52 | 0.24 | 4 1 6 | 14 |
20 | 52.92 | 52.92 | 0.00 | 2 0 20 | 25 |
21 | 59.48 | 59.68 | 0.20 | 5 1 7 | 12 |
Mode | TCP Target (cm−1) | SrCu-TCP Target (cm−1) | Band Shift (cm−1) |
---|---|---|---|
ν3 | 1120 | 1125 | 5 |
ν1 | 1042 | 1027 | −15 |
ν4 | 605 | 590 | 15 |
ν4 | 549 | 554 | −6 |
Sr, wt% | Cu, wt% | ||||
---|---|---|---|---|---|
EDX (Coatings) | AAS (Targets) | Theoretical Value, in Ca2.5Sr0.25Cu0.25(PO4)2 Powder | EDX (Coatings) | AAS (Targets) | Theoretical Value, in Ca2.5Sr0.25Cu0.25(PO4)2 Powder |
6.54 ± 0.33 | 6.68 ± 0.05 | 6.71 | 4.10 ± 0.18 | 4.78 ± 0.05 | 4.84 |
OD 600 nm | SD | % Growth | % Inhibition | |
---|---|---|---|---|
S. aureus | ||||
CTR+ | 1.009 | 0.03 | 100.0 | 0.0 |
TCP | 0.980 | 0.05 | 97.1 | 2.9 |
SrCu-TCP | 0.695 | 0.04 | 68.9 | 31.1 |
P. aeruginosa | ||||
CTR+ | 0.984 | 0.03 | 100.0 | 0.0 |
TCP | 0.983 | 0.09 | 99.9 | 0.1 |
SrCu-TCP | 0.753 | 0.08 | 76.5 | 23.5 |
E. coli | ||||
CTR+ | 1.204 | 0.17 | 100.0 | 0.0 |
TCP | 1.179 | 0.11 | 97.9 | 2.1 |
SrCu-TCP | 0.858 | 0.21 | 71.3 | 28.7 |
E. faecalis | ||||
CTR+ | 0.995 | 0.17 | 100.0 | 0.0 |
TCP | 0.973 | 0.07 | 97.8 | 2.2 |
SrCu-TCP | 0.643 | 0.21 | 64.7 | 35.3 |
C. albicans | ||||
CTR+ | 0.810 | 0.15 | 100.0 | 0.0 |
TCP | 0.792 | 0.09 | 97.8 | 2.2 |
SrCu-TCP | 0.611 | 0.12 | 75.4 | 24.6 |
% Inhibition | ||||||
---|---|---|---|---|---|---|
Sample | S. aureus | P. aeruginosa | E. coli | E. faecalis | C. albicans | Reference |
SrCu-TCP (coating) | 31.1 | 23.5 | 28.7 | 35.3 | 24.6 | present study |
SrCu-TCP (powder) | 92.0 | 95.5 | 64.9 | 96.3 | 70.9 | [57] |
SrMn-TCP (coating) | 12.2 | 9.4 | 9.0 | 9.7 | 50.0 | [44] |
SrMn-TCP (powder) | 57.8 | 92.9 | 19.0 | 67.4 | 41.9 | [57] |
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Rau, J.V.; De Bonis, A.; Curcio, M.; Barbaro, K.; Fosca, M.; Fadeeva, I.V.; Cardoso, G.C.; Teghil, R.; Slonskaya, T.K.; Zheng, Y. Coated Biodegradable Zinc Lithium Alloys: Development and Characterization of Co-Doped Strontium Copper Tricalcium Phosphate Coating for Antimicrobial Applications. Coatings 2024, 14, 1073. https://doi.org/10.3390/coatings14081073
Rau JV, De Bonis A, Curcio M, Barbaro K, Fosca M, Fadeeva IV, Cardoso GC, Teghil R, Slonskaya TK, Zheng Y. Coated Biodegradable Zinc Lithium Alloys: Development and Characterization of Co-Doped Strontium Copper Tricalcium Phosphate Coating for Antimicrobial Applications. Coatings. 2024; 14(8):1073. https://doi.org/10.3390/coatings14081073
Chicago/Turabian StyleRau, Julietta V., Angela De Bonis, Mariangela Curcio, Katia Barbaro, Marco Fosca, Inna V. Fadeeva, Giovana Collombaro Cardoso, Roberto Teghil, Tatiana K. Slonskaya, and Yufeng Zheng. 2024. "Coated Biodegradable Zinc Lithium Alloys: Development and Characterization of Co-Doped Strontium Copper Tricalcium Phosphate Coating for Antimicrobial Applications" Coatings 14, no. 8: 1073. https://doi.org/10.3390/coatings14081073