Magnetic Resonance Assessment of Ejection Fraction Versus Echocardiography for Cardioverter-Defibrillator Implantation Eligibility
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design and Setting
- related to echocardiography (comorbidities altering the quality of echocardiography):
- obesity;
- emphysema;
- specific to CMR:
- claustrophobia;
- metallic prosthetic implants;
- known allergy to the contrast agents;
- related to patient conditions:
- uncontrolled arrhythmias;
- pregnancy or lactation;
- high-grade valve diseases or shunts;
- a cardiac resynchronization or a cardiac revascularization procedure that happened between 2DE and CMR examinations.
2.2. Echocardiography
2.3. Cardiovascular Magnetic Resonance—Acquisition and Analysis
2.4. Statistical Analysis
3. Results
3.1. Baseline Patient Characteristics
3.2. Agreement between CMR and Echocardiography Measurements
3.3. The Specific Value of EF Agreement between CMR and Cardiac Echography and Its Implication in ICD Eligibility
4. Discussion
4.1. Quantitative Measurements Agreement
4.2. Qualitative EF Measurements’ Agreement and ICD Eligibility Implications
4.3. Comparison with Other Studies
4.4. Discussion about Future of Diagnostic Method Roles in ICD Eligibility
4.5. Generalisability
4.6. Limitations
4.7. Study Strengths
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristic | Number (%) (n = 166) |
---|---|
Age (years), mean (SD) | 46.35 (16.16) |
Males, n (%) | 119/166 (71.69) |
BMI (kg/m2), median (IQR) | 25.72 (23.35–29.36) |
BSA, median (IQR) | 1.95 (1.82–2.08) |
Heart disease, n (%) | |
Dilatative cardiomyopathy | 102/166 (61.45) |
Hypertrophic cardiomyopathy | 21/166 (12.65) |
Myocarditis | 34/166 (20.48) |
Fibrosis | 9/166 (5.42) |
Clinical symptoms | 121/152 (79.61) |
NYHA class | 1: 43/141 (30.5) |
2: 41/141 (29.08) | |
3: 56/141 (39.72) | |
4: 1/141 (0.71) | |
High blood pressure | 43/148 (29.05) |
Smoker, n (%) | 67/156 (42.95) |
Diabetes, n (%) | 32/156 (20.51) |
LVEF CMR, median (IQR) | 40.6 (25.2–56.15) |
LVEF echography, median (IQR) | 42 (29.5–55) |
EDV-LV CMR, median (IQR) | 207.25 (157.48–278.75) |
EDV-LV echography, median (IQR) | 150 (108–201) |
ESV-LV CMR, median (IQR) | 127 (66.62–201.4) |
ESV-LV echography, median (IQR) | 86 (52–132) |
IVS CMR, median (IQR) | 10 (9–11) |
IVS echography, median (IQR) | 11 (9–12) |
Bias * (95% CI) | Limits of Agreement *, lb~ub (95% CI) | Bias BA (95% CI) | Limits of Agreement BA, lb~ub (95% CI) | |
---|---|---|---|---|
EDV LV | 61.7 (95% CI 49.6–76.5) | −51.8 (95% CI −57.2–−36.5)~204.2 (95% CI 166.6–230.1) | 68.3 (58.2–78.4) | −59.4 (−69.5–−49.3)~196 (185.9–206.2) |
ESV LV | 32.3 (95% CI 24.7–39.6) | −44.3 (95% CI −69.2–−20)~176 (95% CI 157.9–195.7) | 47.3 (38.4–56.3) | −65.3 (−74.2–−56.3)~159.9 (151–168.9) |
EF | −0.9 (95% CI−3.2–1.3) | −20.4 (95% CI −23.7–−17.1)~19.6 (95% CI 15.5–24.7) | −0.7 (−2.3–0.9) | −20.5 (−22.2–−18.9)~19.1 (17.5–20.7) |
CMR EF | |||
---|---|---|---|
Echography EF (all subjects) | >=35% n (% of total) | <35% n (% of total) | Total |
>=35% | 84 (55.6) | 12 (7.9) | 96 |
<35% | 4 (2.6) | 51 (33.8) | 55 |
Total | 88 | 63 | 151 * |
Echography EF (CMR EF < 50%) | >=35% | <35% | Total |
>=35% | 20 (23.0) | 12 (13.8) | 32 |
<35% | 4 (4.6) | 51 (58.6) | 55 |
Total | 24 | 63 | 87 * |
Echography EF (all subjects) | >=30% | <30% | Total |
>=30% | 96 (63.6) | 17 (11.3) | 113 |
< 30% | 5 (3.3) | 33 (21.9) | 38 |
Total | 101 | 50 | 151 * |
Echography EF (CMR EF < 35%) | >=30% | <30% | Total |
>=30% | 10 (15.9) | 17 (27.0) | 27 |
<30% | 3 (4.8) | 33 (52.4) | 38 |
Total | 13 | 50 | 151 * |
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Schiau, C.; Leucuța, D.-C.; Dudea, S.M.; Manole, S. Magnetic Resonance Assessment of Ejection Fraction Versus Echocardiography for Cardioverter-Defibrillator Implantation Eligibility. Biology 2021, 10, 1108. https://doi.org/10.3390/biology10111108
Schiau C, Leucuța D-C, Dudea SM, Manole S. Magnetic Resonance Assessment of Ejection Fraction Versus Echocardiography for Cardioverter-Defibrillator Implantation Eligibility. Biology. 2021; 10(11):1108. https://doi.org/10.3390/biology10111108
Chicago/Turabian StyleSchiau, Călin, Daniel-Corneliu Leucuța, Sorin Marian Dudea, and Simona Manole. 2021. "Magnetic Resonance Assessment of Ejection Fraction Versus Echocardiography for Cardioverter-Defibrillator Implantation Eligibility" Biology 10, no. 11: 1108. https://doi.org/10.3390/biology10111108
APA StyleSchiau, C., Leucuța, D. -C., Dudea, S. M., & Manole, S. (2021). Magnetic Resonance Assessment of Ejection Fraction Versus Echocardiography for Cardioverter-Defibrillator Implantation Eligibility. Biology, 10(11), 1108. https://doi.org/10.3390/biology10111108