Modeling Post-Scratching Locomotion with Two Rhythm Generators and a Shared Pattern Formation
by
Jesus A. Tapia
1, 
Argelia Reid
2,
John Reid
2,
Saul M. Dominguez-Nicolas
3 and
Elias Manjarrez
2,* 1
Facultad de Ciencias Biológicas, Benemérita Universidad Autónoma de Puebla, Blvd, Valsequillo y Av. San Claudio, Ed. BIO 1, Puebla Pue 72570, Mexico
2
Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, Col. San Manuel, Apartado Postal 406, Puebla Pue 72570, Mexico
3
Centro de Investigación en Micro y Nanotecnología, Universidad Veracruzana, Calzada Ruiz Cortines 455 Boca del Rio, Veracruz 94294, Mexico
*
Author to whom correspondence should be addressed.
Biology 2021, 10(7), 663; https://doi.org/10.3390/biology10070663
Submission received: 6 June 2021
/
Revised: 9 July 2021
/
Accepted: 9 July 2021
/
Published: 14 July 2021
(This article belongs to the Special Issue Information Processing in Neuronal Circuits and Systems)
Simple Summary
Post-scratching locomotion in cats refers to the spontaneous occurrence of an episode of locomotion generated after an event of scratching. This phenomenon suggests the potential existence of shared neurons in the spinal cord mediating the transition from one rhythmic motor task to another. Here, we examine this possibility with a mathematical model, reproducing the experimental observations. Our findings reveal a possible mechanism in which the central nervous system could share neuronal circuits from two central pattern generators to produce a sequence of different rhythmic motor actions.
Abstract
This study aimed to present a model of post-scratching locomotion with two intermixed central pattern generator (CPG) networks, one for scratching and another for locomotion. We hypothesized that the rhythm generator layers for each CPG are different, with the condition that both CPGs share their supraspinal circuits and their motor outputs at the level of their pattern formation networks. We show that the model reproduces the post-scratching locomotion latency of 6.2 ± 3.5 s, and the mean cycle durations for scratching and post-scratching locomotion of 0.3 ± 0.09 s and 1.7 ± 0.6 s, respectively, which were observed in a previous experimental study. Our findings show how the transition of two rhythmic movements could be mediated by information exchanged between their CPG circuits through routes converging in a common pattern formation layer. This integrated organization may provide flexible and effective connectivity despite the rigidity of the anatomical connections in the spinal cord circuitry.
