The TRPV6 Calcium Channel and Its Relationship with Cancer

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

please see attached file

Comments for author File: Comments.pdf

Comments on the Quality of English Language

I would suggest that the authors have the manuscript revised by a native speaker.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

Comments and Suggestions for Authors

This is a straightforward review of a topic of current interest.  The manuscript does focus on the material described in the title and abstract.  The manuscript reds reasonably well.  However, there are a number of editorial problems.

Introduction:

The uncited statement that calcium is the most common in in the body is a ludicrous statement.

The body gets its calcium from the diet, not from "dietary requirements".

Main text:

The parts of Figure 1 are not labelled A, B, and C in the figure itself.  The source of the data used to generate the figures should be cited in the Figure caption.

I could not find the abbreviation for calmodulin was ever identified.  The abbreviation also varies between "CaM" and "cam".  Subsequently, I found numerous abbreviations that were never defined.  A reviewer unfamiliar with the field would find much of the last half of the manuscript uninterpretable.

The charges on ions should be superscripts.

Overall, this could be a good review article; however, the authors need to be much more careful in editing.

Comments on the Quality of English Language

The English grammar is good enough not to distract the reader.  However, some finer points of English grammar are occasionally incorrect.  Verb tense changes within some paragraphs, for example. Font size changes in some places in the manuscript.

How recent is "recent"?  Some research described as recent is a decade old.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

Comments and Suggestions for Authors

revisions are satisfactory for publication

Author Response

Please see the attachment

Author Response File: Author Response.docx