Prostaglandin E2 and Cancer: Insight into Tumor Progression and Immunity
Abstract
:Simple Summary
Abstract
1. Introduction
2. Prostaglandin E2 Biosynthesis and Functions
3. Prostaglandin E2 and Cancer
4. Molecular Mechanisms Linking PGE2 and Tumor Progression
PGE2 and Angiogenesis
5. PGE2 and Its Roles in the Regulation of the Tumor Microenvironment
5.1. PGE2 and Myeloid-Derived Suppressor Cells
5.1.1. PGE2 and MDSCs Differentiation
5.1.2. PGE2 and MDSCs Recruitment
5.1.3. PGE2 and MDSCs Activation
5.1.4. PGE2, MDSCs, and Resistance to Immunotherapy
5.2. PGE2 and Tumor-Associated Macrophages
5.2.1. Role of PGE2 in Controlling Macrophage Polarization
5.2.2. Role of PGE2 in Controlling Macrophage Migration
5.3. PGE2 and Dendritic Cells
5.3.1. PGE2 and DC Differentiation
5.3.2. PGE2 and DC Migration
5.4. PGE2 and Natural Killer Cells
PGE2 and NK Activity
5.5. PGE2 and T-Cells
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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NSAID | Cancer | References |
---|---|---|
Aspirin | Colorectal cancer | [3,18,32,33,34,35,36,37,38,39,40,41,42,43,44,45] |
Breast cancer | [17,41,46,47,48,49,50,51] | |
Head and neck squamous cell carcinoma | [52,53,54,55,56,57,58,59,60] | |
Lung cancer | [3,37,38,43,61] | |
Prostate cancer | [3,62] | |
Ovarian cancer | [37,63,64,65] | |
Gastric cancer | [3,37,66,67,68,69,70] | |
Coxib | Breast cancer | [31,71,72,73,74,75,76] |
Colon cancer | [31,76,77,78,79] | |
Prostate cancer | [31,76] | |
Lung cancer | [31,76,80,81,82,83] |
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Finetti, F.; Travelli, C.; Ercoli, J.; Colombo, G.; Buoso, E.; Trabalzini, L. Prostaglandin E2 and Cancer: Insight into Tumor Progression and Immunity. Biology 2020, 9, 434. https://doi.org/10.3390/biology9120434
Finetti F, Travelli C, Ercoli J, Colombo G, Buoso E, Trabalzini L. Prostaglandin E2 and Cancer: Insight into Tumor Progression and Immunity. Biology. 2020; 9(12):434. https://doi.org/10.3390/biology9120434
Chicago/Turabian StyleFinetti, Federica, Cristina Travelli, Jasmine Ercoli, Giorgia Colombo, Erica Buoso, and Lorenza Trabalzini. 2020. "Prostaglandin E2 and Cancer: Insight into Tumor Progression and Immunity" Biology 9, no. 12: 434. https://doi.org/10.3390/biology9120434