The Efficacy of the Novel TSPO Ligands 2-Cl-MGV-1 and 2,4-Di-Cl-MGV-1 Compared to the Classical TSPO Ligand PK 11195 to Counteract the Release of Chemokines from LPS-Stimulated BV-2 Microglial Cells
Abstract
:1. Introduction
2. Methods
2.1. BV-2 Microglial Cells
2.2. LPS Exposure
2.3. TSPO Ligands Treatment
2.4. Trypan Blue Staining for Cell Counting
2.5. Enzyme-Linked Immunosorbent Assay (ELISA)
2.6. Statistical Analyses
3. Results
3.1. CCL2 (MCP1)
3.2. CCL3 (MIP1α)
3.3. CCL5 (RANTES)
3.4. CCL8 (MCP2)
3.5. IL-2 Cytokine
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Monga, S.; Weizman, A.; Gavish, M. The Efficacy of the Novel TSPO Ligands 2-Cl-MGV-1 and 2,4-Di-Cl-MGV-1 Compared to the Classical TSPO Ligand PK 11195 to Counteract the Release of Chemokines from LPS-Stimulated BV-2 Microglial Cells. Biology 2020, 9, 291. https://doi.org/10.3390/biology9090291
Monga S, Weizman A, Gavish M. The Efficacy of the Novel TSPO Ligands 2-Cl-MGV-1 and 2,4-Di-Cl-MGV-1 Compared to the Classical TSPO Ligand PK 11195 to Counteract the Release of Chemokines from LPS-Stimulated BV-2 Microglial Cells. Biology. 2020; 9(9):291. https://doi.org/10.3390/biology9090291
Chicago/Turabian StyleMonga, Sheelu, Abraham Weizman, and Moshe Gavish. 2020. "The Efficacy of the Novel TSPO Ligands 2-Cl-MGV-1 and 2,4-Di-Cl-MGV-1 Compared to the Classical TSPO Ligand PK 11195 to Counteract the Release of Chemokines from LPS-Stimulated BV-2 Microglial Cells" Biology 9, no. 9: 291. https://doi.org/10.3390/biology9090291
APA StyleMonga, S., Weizman, A., & Gavish, M. (2020). The Efficacy of the Novel TSPO Ligands 2-Cl-MGV-1 and 2,4-Di-Cl-MGV-1 Compared to the Classical TSPO Ligand PK 11195 to Counteract the Release of Chemokines from LPS-Stimulated BV-2 Microglial Cells. Biology, 9(9), 291. https://doi.org/10.3390/biology9090291