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Article

Exploring the Potential Anti-Inflammatory and Wound-Healing Proprieties of Cepaea hortensis Snail Mucin

by
Fatima Errajouani
1,2,
Hanane Bakrim
3,
Sohaib Hourfane
4,
Adnane Louajri
1,
João Miguel Rocha
5,6,7,
Noureddine El Aouad
4,* and
Amin Laglaoui
3
1
Biosciences, Environment and Health Laboratory, Faculty of Sciences—Tetouan, University Abdelmalek Essaâdi, Tetouan 93000, Morocco
2
Central Pharmacy University Hospital Center Mohamed VI, Route de Rabat KM 17 BP 398, Geznaya, Tanger 90100, Morocco
3
Biotechnology and Biomolecules Engineering Research Team (BBERT), Faculty of Science and Technology—Tangier, University Abdelmalik Essaâdi, Tetouan 93000, Morocco
4
Laboratory of Life and Health Sciences, Faculty of Medicine and Pharmacy, Route de Rabat km 15 Gzenaya BP 365 Tanger, University Abdelmalek Essaâdi, Tetouan 9300, Morocco
5
Universidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
6
LEPABE—Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto (FEUP), Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal
7
AliCE—Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto (FEUP), Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal
*
Author to whom correspondence should be addressed.
Cosmetics 2023, 10(6), 170; https://doi.org/10.3390/cosmetics10060170
Submission received: 18 October 2023 / Revised: 4 December 2023 / Accepted: 7 December 2023 / Published: 14 December 2023
(This article belongs to the Special Issue Aromatic and Medicinal Plants as Source of Bioactive Natural Compounds with Cosmetic Applications—Volume 2)
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Abstract

Long before its popularization as a skincare ingredient, snail slime was reported to have a variety of health-promoting attributes. Its medicinal use involved the treatment of ailments, such as anthrax, hernias, stomach pain, chest pain, as well as tuberculosis. The main aim of this study was to investigate the anti-inflammatory and wound-healing properties of snail slime from Cepaea hortensis (Müller, 1774) (brown garden snail). The slime was extracted by a mild method, and the anti-inflammatory characteristics were determined by croton-oil-induced mouse-ear edema. The histological study showed that the snail slime exerts its action at the level of inflammatory mediators, explaining the drastic decrease of edema (59% in comparison to the 47% of indomethacin). The daily application of 50 µL (15 mg/kg) of snail slime on excision wounds in rabbits proved to induce an almost full tissue repair after 24 days of treatment (87.80–92.7% wound closure in width and length, respectively). Analysis of the slime’s safety aspect allowed affirming the nontoxicity of snail slime on both the skin and eyes.
Keywords: snail slime; anti-inflammatory; wound healing; toxicity; edema; pharmacological properties snail slime; anti-inflammatory; wound healing; toxicity; edema; pharmacological properties

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MDPI and ACS Style

Errajouani, F.; Bakrim, H.; Hourfane, S.; Louajri, A.; Rocha, J.M.; El Aouad, N.; Laglaoui, A. Exploring the Potential Anti-Inflammatory and Wound-Healing Proprieties of Cepaea hortensis Snail Mucin. Cosmetics 2023, 10, 170. https://doi.org/10.3390/cosmetics10060170

AMA Style

Errajouani F, Bakrim H, Hourfane S, Louajri A, Rocha JM, El Aouad N, Laglaoui A. Exploring the Potential Anti-Inflammatory and Wound-Healing Proprieties of Cepaea hortensis Snail Mucin. Cosmetics. 2023; 10(6):170. https://doi.org/10.3390/cosmetics10060170

Chicago/Turabian Style

Errajouani, Fatima, Hanane Bakrim, Sohaib Hourfane, Adnane Louajri, João Miguel Rocha, Noureddine El Aouad, and Amin Laglaoui. 2023. "Exploring the Potential Anti-Inflammatory and Wound-Healing Proprieties of Cepaea hortensis Snail Mucin" Cosmetics 10, no. 6: 170. https://doi.org/10.3390/cosmetics10060170

APA Style

Errajouani, F., Bakrim, H., Hourfane, S., Louajri, A., Rocha, J. M., El Aouad, N., & Laglaoui, A. (2023). Exploring the Potential Anti-Inflammatory and Wound-Healing Proprieties of Cepaea hortensis Snail Mucin. Cosmetics, 10(6), 170. https://doi.org/10.3390/cosmetics10060170

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