Journal Description
Cosmetics
Cosmetics
is an international, scientific, peer-reviewed, open access journal on the science and technology of cosmetics published bimonthly online by MDPI.
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within Scopus, ESCI (Web of Science), CAPlus / SciFinder, and other databases.
- Journal Rank: JCR - Q2 (Dermatology) / CiteScore - Q1 (Surgery)
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 18 days after submission; acceptance to publication is undertaken in 6.6 days (median values for papers published in this journal in the second half of 2023).
- Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.
Impact Factor:
3.4 (2023)
Latest Articles
Artificial Intelligence in Plastic Surgery: Advancements, Applications, and Future
Cosmetics 2024, 11(4), 109; https://doi.org/10.3390/cosmetics11040109 - 27 Jun 2024
Abstract
Artificial intelligence (AI) is revolutionizing plastic surgery through its remarkable advancements in various domains such as image analysis, robotic assistance, predictive analytics, and augmented reality. Predictive analytics, powered by AI, harnesses patient data to predict surgical outcomes, minimize risks, and tailor treatment plans,
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Artificial intelligence (AI) is revolutionizing plastic surgery through its remarkable advancements in various domains such as image analysis, robotic assistance, predictive analytics, and augmented reality. Predictive analytics, powered by AI, harnesses patient data to predict surgical outcomes, minimize risks, and tailor treatment plans, thereby optimizing patient care and safety. Augmented reality and virtual reality technology are also reshaping the cosmetic surgery landscape, providing immersive experiences for preoperative imaging, intraoperative guidance, and advanced skills through simulation. Looking ahead, the future of AI in plastic surgery holds great promise, including personalized medicine, bioprinting of tissues and organs, and continuous learning through iterative improvement algorithms based on real-world surgical experience. However, amid these transformational advances, ethical considerations and regulatory frameworks must evolve to ensure the responsible deployment of AI, protect patient privacy, minimize errors and algorithmic deviation, and uphold standards of fairness and transparency. Our study aims to explore the role of AI in the field of plastic surgery with the potential for the future in mind. In summary, AI is considered a beacon of innovation in plastic surgery, enhancing surgical precision, enhancing patient outcomes, and heralding a future where interventions rely on personalized technology that will redefine the boundaries of aesthetic and regenerative medicine.
Full article
Open AccessReview
Examining How Diet and Lifestyle Influence Skin Appearance through a Common Risk Factor: Excess Iron—A Comprehensive Review
by
Tianshu Yang, Lungchi Chen and Xi Huang
Cosmetics 2024, 11(4), 108; https://doi.org/10.3390/cosmetics11040108 - 27 Jun 2024
Abstract
In the contemporary era, youthful and healthy skin is a pivotal determinant of beauty. Choices pertaining to one’s dietary and lifestyle practices wield substantial influence over skin health. Currently, the focal point of attention lies in strategies that delay skin aging and maintain
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In the contemporary era, youthful and healthy skin is a pivotal determinant of beauty. Choices pertaining to one’s dietary and lifestyle practices wield substantial influence over skin health. Currently, the focal point of attention lies in strategies that delay skin aging and maintain skin quality. Remarkably, the skin, the body’s largest organ, serves as the primary defense barrier against external elements. Skin aging encompasses intrinsic and extrinsic categories, both susceptible to genetic, lifestyle, and environmental factors. Given the strides in science and technology, the pursuit of effective and safe interventions for skin aging assumes paramount importance. Thus, this review delves into the intricate relationship between diet, lifestyle, and skin aging, culminating in an exploration of the crucial role played by excess iron in this intricate nexus. Understanding these dynamics holds promise for advancing our knowledge of skincare and the quest for timeless vitality.
Full article
(This article belongs to the Special Issue Chinese American Cosmetic Professional Association (CACPA)—a Collaborative and Inclusive Platform for Research and Education of Cosmetic and Personal Care Products)
Open AccessArticle
Extending the Physical Functionality of Bioactive Blends of Astrocaryum Pulp and Kernel Oils from Guyana
by
Laziz Bouzidi, Shaveshwar Deonarine, Navindra Soodoo, R. J. Neil Emery, Sanela Martic and Suresh S. Narine
Cosmetics 2024, 11(4), 107; https://doi.org/10.3390/cosmetics11040107 - 26 Jun 2024
Abstract
Natural lipids with nutritional or therapeutic benefits that also provide desired texture, melting and organoleptic appeal (mouthfeel, skin feel) are difficult to procure for the food and cosmetics industries. Natural Astrocaryum pulp oil (AVP) and kernel fat (AVK) from Guyana were blended without
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Natural lipids with nutritional or therapeutic benefits that also provide desired texture, melting and organoleptic appeal (mouthfeel, skin feel) are difficult to procure for the food and cosmetics industries. Natural Astrocaryum pulp oil (AVP) and kernel fat (AVK) from Guyana were blended without further modification to study the potential of extending the physical functionality of the blends beyond that of crude AVK and AVP. An evaluation of non-lipid components by ESI-MS indicated twenty-four (24) bioactive molecules, mainly carotenoids (90%), polyphenols (9%) and sterols (1%) in AVP, indicating important health and therapeutic benefits. Only trace-to-negligible amounts of these compounds were detected in AVK. The thermal transition phase behavior, solid fat content (SFC), microstructure and textural properties of five AVP/AVL blends were used to construct phase diagrams of the AVK/AVP binary system. Binary phase diagrams constructed from the cooling and heating DSC thermograms of the mixtures and description of the liquidus line indicated a mixing behavior close to ideal with a tendency for order, with no phase separation. Melting onsets, solid fat content and measurements of solid-like texture all predictively increased with increasing AVK content. The descriptive decay parameters obtained for SFC, crystal size, hardness, firmness and spreadability were similar and predictive and indicate the way the binary system structure approaches that of a liquid or a functional solid. The bioactive content of the blends was accurately calculated; the work provides a blueprint for the blending of AVP and AVK to deliver targeted bioactive content, stability, spreadability, texture, melting profile, organoleptic appeal and solid content. SFCs at 20 °C ranged from 9.1% to 39.1%, melting onset from −17.5 °C to 27.8 °C, hardness from 0.1 N to 3.5 N and spreadability from 3.3 N·s to 147.1 N·s; indicating a useful dynamic range of physical properties suitable for bioactive oils to bioactive butters.
Full article
(This article belongs to the Special Issue Application of Plant-Based Molecules and Materials in Cosmetics)
Open AccessArticle
The Influence of Physical Characteristics of Wet Wipe Fabrics on the Microbial Biomass Accumulation
by
Noa Ziklo, Idit Yuli, Maayan Bibi and Paul Salama
Cosmetics 2024, 11(4), 106; https://doi.org/10.3390/cosmetics11040106 - 26 Jun 2024
Abstract
The physicochemical properties of nonwoven wet wipe fabrics have a strong influence on the ability of microorganisms to attach and multiply, until a biofilm is formed. Cellulose-based fabrics, being biodegradable, represent a major contamination risk. In addition, having a hydrophilic nature, they provide
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The physicochemical properties of nonwoven wet wipe fabrics have a strong influence on the ability of microorganisms to attach and multiply, until a biofilm is formed. Cellulose-based fabrics, being biodegradable, represent a major contamination risk. In addition, having a hydrophilic nature, they provide a good platform for microorganisms attachment. To optimize biodegradable wet wipes antimicrobial quality, it is crucial to assess the impact of physicochemical properties, e.g., density, pore size, fiber diameter, contact angle and surface charge. Here, we investigated the physical characteristics of commonly used nonwoven fabrics from both synthetic (Polyethylene terephthalate, PET) and natural components (wood pulp and viscose), to evaluate their effect on microbial contamination. We found that the hydrophobicity of the fabric had varying influence on attachment, depending on the microbial strain. However, the geometry, as well as the fabric pore size greatly affected attachment regardless of the microbial strain, in which a larger pore size resulted in lower accumulation of microbial biomass. Our study gives insight into the characteristics of wet wipes that can affect the preservation efficacy and microbial contamination risk, in one of the biggest segments in the personal care industry.
Full article
Open AccessArticle
The Inhibition of Oxidative Stress-Mediated Cell Apoptosis by the Caspase Inhibitor (S)-3-((S)-2-(6-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-oxoisoindolin-2-yl)butanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic Acid in Human Dermal Papilla Cells
by
Bomi Park, Daeun Kim, Yurim Lee, Seihyun Choi, HeeDong Park, Sanghwa Lee and Jaesung Hwang
Cosmetics 2024, 11(4), 105; https://doi.org/10.3390/cosmetics11040105 - 22 Jun 2024
Abstract
Alopecia is traditionally viewed as androgen-dependent, but emerging evidence has implicated oxidative stress in the pathogenesis of hair loss. Current treatments for alopecia have limited efficacy, leading to the need for new therapies. Human dermal papilla cells (hDPCs) play a pivotal role in
[...] Read more.
Alopecia is traditionally viewed as androgen-dependent, but emerging evidence has implicated oxidative stress in the pathogenesis of hair loss. Current treatments for alopecia have limited efficacy, leading to the need for new therapies. Human dermal papilla cells (hDPCs) play a pivotal role in hair follicle (HF) development and hair growth regulation. In this study, we investigated the potential of (S)-3-((S)-2-(6-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-oxoisoindolin-2-yl)butanamido)-4-oxo-5-(2,3,5,6 tetrafluorophenoxy) pentanoic acid (THPA), a pan-caspase inhibitor, to reduce ROS-induced cellular damage and apoptosis in hDPCs. Our study revealed that THPA effectively suppressed hydrogen peroxide-induced apoptosis while also attenuating activated caspase signaling. Additionally, THPA restored the down-regulated expression of β-catenin, a key mediator of the Wnt/β-catenin pathway, in hDPCs exposed to hydrogen peroxide. Furthermore, significant alterations in Akt/mTOR/p70S6K signaling were observed following THPA treatment. Notably, THPA treatment led to a reduction in the expression of Dickkopf-1 (DKK-1), an inhibitor of the Wnt/β-catenin pathway implicated in hair follicle regression. Moreover, THPA treatment decreased the expression of the cell senescence markers p21 and p16, suggesting a potential role in preserving hDPC function and delaying hair follicle regression. Collectively, our findings highlight the therapeutic potential of THPA in preventing hair loss by protecting hDPCs against oxidative stress damage.
Full article
(This article belongs to the Special Issue Current and Future Trends in Cosmetics Research: The 10th Anniversary of Cosmetics)
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Open AccessArticle
Development of an Antioxidant, Anti-Aging, and Photoprotective Phytocosmetic from Discarded Agave sisalana Perrine Roots
by
Guilherme dos Santos Mazo, Julia Amanda Rodrigues Fracasso, Luísa Taynara Silvério da Costa, Valdecir Farias Ximenes, Natália Alves Zoppe, Amanda Martins Viel, Lucas Pires Guarnier, Beatriz de Castro Silva, Luan Victor Coelho de Almeida and Lucinéia dos Santos
Cosmetics 2024, 11(3), 104; https://doi.org/10.3390/cosmetics11030104 - 20 Jun 2024
Abstract
The primary source of hard fiber globally is Agave sisalana Perrine, also known as sisal. In areas where sisal is grown, the roots of the plant are usually left in the field after it has stopped producing, which leads to soil degradation and
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The primary source of hard fiber globally is Agave sisalana Perrine, also known as sisal. In areas where sisal is grown, the roots of the plant are usually left in the field after it has stopped producing, which leads to soil degradation and decreased sisal productivity. It is, therefore, critical to find alternatives to reuse this waste. This study explores the potential use of sisal waste in the cosmetic industry by incorporating a hydroethanolic extract (HER) into a cream–gel formulation, taking advantage of the plant’s recognized ethnopharmacological value. The study involves analyzing the extract’s phytochemical composition (flavonoids) and evaluating its cytotoxicity. Subsequently, the antioxidant and antiglycation activities of the extract and cream–gel are evaluated, as well as ex vivo ocular toxicity, photoprotective activity, and preliminary stability analyses. The HER extract showed a flavonoid composition (catechin, kaempferol, isorhamnetin, and chrysin) and maintained cell viability above 70% throughout all time points analyzed in the MTT assay. Furthermore, the extract and the formulation demonstrated proven antioxidant and antiglycation activities. The cream–gel’s UVB and UVA protection effectiveness with the HER was comparable to that of synthetic UVB/UVA sunscreens, with the samples proving nonirritating and stable. In conclusion, the extract has a significant presence of flavonoids, and the cream–gel developed with it did not present cytotoxicity and met the stability requirements, indicating phytocosmetic potential with antioxidant, antiglycation, and photoprotective properties.
Full article
(This article belongs to the Special Issue Natural Sources for Cosmetic Ingredients: Challenges and Innovations)
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Open AccessArticle
Establishing the Inhibition of the Serine Protease Plasmin as a Skin Anti-Aging Pathway
by
Remo Campiche, Dominik Imfeld, Chennakesava Cuddapah, Leithe Budel and Mathias Gempeler
Cosmetics 2024, 11(3), 103; https://doi.org/10.3390/cosmetics11030103 - 19 Jun 2024
Abstract
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Plasmin is a serine protease induced by UV-irradiation in skin that contributes to inflammation. We showed that plasmin is upregulated in photo-exposed facial skin and that this correlates with increased transepidermal water loss (TEWL). Plasmin activity upregulates downstream pathways such as pro-inflammatory cytokines
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Plasmin is a serine protease induced by UV-irradiation in skin that contributes to inflammation. We showed that plasmin is upregulated in photo-exposed facial skin and that this correlates with increased transepidermal water loss (TEWL). Plasmin activity upregulates downstream pathways such as pro-inflammatory cytokines and matrix-metalloproteinases (MMPs). In addition, the plasminogen system modulates cutaneous melanogenesis. In this study, we investigated potential skin-aging effects of plasmin with a dual inhibitor of plasmin and its activator urokinase (uPA). We established a range of in vitro and ex vivo assays to investigate inflammation, MMP-9 activation, and collagen modulation, and the melanogenesis modulation activity of plasmin. A specific plasmin inhibitor, Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (ABSHA), was used in these assays to downregulate these effects. We found that ABSHA was able to down-regulate UV-irradiation-induced MMP-9 expression, and subsequent collagen IV degradation, ex vivo. In addition, the increased melanin synthesis in epidermal melanocytes was reduced significantly by ABSHA. Furthermore, dermal fibroblasts treated with the plasmin inhibitor showed increased collagen I synthesis. We further investigated these effects in a two-month, monocentric, placebo-controlled human study on female Chinese volunteers. We found a significant increase in collagen density by ultrasound measurement and an increase in elasticity by cutometer assessment in the group using a formulation consisting of a 10 ppm ABSHA solution. This resulted in decreased wrinkle volumes on both the forehead and crow’s feet as shown by Primos CR. Looking at age spots, there was a decrease in overall ITA° and melanin density as well as in the total age spot area. Our results establish plasmin as a skin-aging enzyme. Using specific inhibitors against plasmin shows promise against age-induced skin conditions.
Full article
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Open AccessArticle
Exploring the Use of Natural Ingredients for the Protection of Textured Hair from Ultraviolet Radiation: An In Vitro Study
by
Ewa Markiewicz and Olusola C. Idowu
Cosmetics 2024, 11(3), 102; https://doi.org/10.3390/cosmetics11030102 - 19 Jun 2024
Abstract
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Human hair is characterized by significant diversity, which is dictated by the individual genetic makeup. It is estimated that up to 70% of the world’s population has textured hair, with a significant proportion also living in areas with high exposure to ultraviolet radiation
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Human hair is characterized by significant diversity, which is dictated by the individual genetic makeup. It is estimated that up to 70% of the world’s population has textured hair, with a significant proportion also living in areas with high exposure to ultraviolet radiation (UVR). This highlights the unique requirements for textured hair care products that can protect hair shafts from the harmful effects of the environment whilst enhancing the natural features of the fibre. In this study, we investigated the UV-protective effects of hair conditioner formulated from active ingredients, mangiferin, ferulic acid and naringin. The analysis of UV-irradiated straight and textured hair was performed by measurements of hair thickness and darkness, the uptake of the fluorescent dye, spectral absorbance of keratin extracts, ATR-FTIR and SEM. We found that textured hair was more sensitive to UVR-induced changes than straight hair, with the primary molecular targets represented by chemical groups in keratins. Pre-treatment of the hair with conditioner had protective effects against structural damage and oxidative stress caused by UVR. These data indicate the importance of the personalized approach to hair research and the formulation of hair care products tailored to the individual demands of textured hair types.
Full article
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Open AccessArticle
Effects of CE Ferulic® Combined with Microneedling in the Treatment of Pigmentary Disorders: A Monocentric, Split Face, Comparative Study
by
Ilaria Proietti, Stefania Guida, Agnieszka Dybala, Alessandra Spagnoli and Concetta Potenza
Cosmetics 2024, 11(3), 101; https://doi.org/10.3390/cosmetics11030101 - 17 Jun 2024
Abstract
Pigmentary disorders of the face present a significant challenge in dermatology, impacting the confidence and well-being of affected individuals. Various approaches have been developed to address these concerns, including microneedling and topical vitamin C products. This study involved 15 participants undergoing three treatment
[...] Read more.
Pigmentary disorders of the face present a significant challenge in dermatology, impacting the confidence and well-being of affected individuals. Various approaches have been developed to address these concerns, including microneedling and topical vitamin C products. This study involved 15 participants undergoing three treatment sessions over 12 weeks, assessing the efficacy of a combined microneedling and CE Ferulic® serum approach. Clinical evaluation and statistical analysis were conducted before and after the intervention. Significant improvement of akin hyperpigmentation was observed, particularly on the side treated with microneedling and CE Ferulic® serum compared to microneedling alone. The integrated treatment protocol demonstrated a synergistic effect in improving skin texture and appearance. Integrated treatment protocols, such as combining microneedling with CE Ferulic® serum, show promise in managing facial hyperpigmentation disorders. Further research with larger cohorts is warranted to validate these findings and optimize treatment strategies, highlighting the potential of combined therapeutic modalities for achieving optimal clinical outcomes in pigmentary disorder management.
Full article
(This article belongs to the Special Issue New Advances in Medical and Cosmetic Dermatology)
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Open AccessArticle
A Split-Face Comparison of Novel Microneedle Patch versus Botulinum Toxin-A and Microneedle Patch for Improvement in Undereye Skin Texture
by
Polen Te, Jitlada Meephansan, Punyaphat Sirithanabadeekul, Purit Pureesrisak, Kittipong Tantisantisom, Sattra Thongma, Yossawat Rayanasukha, Punyanuch Adulyaritthikul and Paisan Khanchaitit
Cosmetics 2024, 11(3), 100; https://doi.org/10.3390/cosmetics11030100 - 17 Jun 2024
Abstract
(1) Background: The emergence of microneedle patch technology and its development as a transdermal drug delivery platform have shown proven results in improving skin texture and appearance. This study was conducted to determine the efficacy of the microneedle patch (MNP)-only cosmesis of undereye
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(1) Background: The emergence of microneedle patch technology and its development as a transdermal drug delivery platform have shown proven results in improving skin texture and appearance. This study was conducted to determine the efficacy of the microneedle patch (MNP)-only cosmesis of undereye skin texture and wrinkles against patch cosmesis with diluted botulinum toxin-A. (2) Methods: A total of 23 Thai females volunteered for this prospective clinical trial. Each participant was treated according to a split-face design, with the application of diluted botulinum toxin-A through MNP technology to the right undereye and a normal saline MNP application to the left undereye. Test areas were recorded at baseline and 2, 4, 8, 12, and 16 weeks after the initial treatment. (3) Results: Botulinum toxin-A was successfully delivered to the skin by MNP technology. After the initial treatment, these novel transdermal drug delivery patches significantly improved infraorbital hollowness at week 8 and wrinkles at week 16. In addition, the skin surface was markedly enhanced, with no adverse effects observed during the trial. (4) Conclusions: Novel MNPs are an effective and safe technology for use in the management of undereye skin aging. Combination treatment with botulinum toxin-A-impregnated devices gave a higher patient satisfaction than MNPs alone.
Full article
(This article belongs to the Special Issue Advanced Delivery Systems for Dermatologic and Dermocosmetics Products)
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Open AccessArticle
Thermophilic Composting as a Means to Evaluate the Biodegradability of Polymers Used in Cosmetic Formulations
by
Timothy W. Gillece, Helen K. Gerardi, Roger L. McMullen, William T. Thompson and Daniel H. Brown
Cosmetics 2024, 11(3), 99; https://doi.org/10.3390/cosmetics11030099 - 16 Jun 2024
Abstract
In the last decade, a growing demand for sustainable cosmetic ingredients has yielded numerous biodegradation protocols. While OECD (Organization for Economic Co-operation and Development) aquatic assays are suitable for water-borne chemicals, it is crucial for the personal care industry to consider the persistence
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In the last decade, a growing demand for sustainable cosmetic ingredients has yielded numerous biodegradation protocols. While OECD (Organization for Economic Co-operation and Development) aquatic assays are suitable for water-borne chemicals, it is crucial for the personal care industry to consider the persistence of plastics in soil, compost, and municipal sludge. Adopting this cradle-to-grave holistic approach would strengthen product appeal while increasing the accuracy and ethical integrity of green product labeling. The aim of our study was to employ quantitative CO2 detection and thermophilic composting protocols specified in ASTM D5338, along with pass level criteria outlined in ASTM D6400, to assess the mineralization of plastics commonly formulated into personal care products. Our results indicate that many cellulose ethers, cationic guars, starches, proteins, and labile polyesters demonstrate satisfactory disintegration, biodegradation, and seed germination rates to secure an ASTM D6400 compostability claim. By contrast, macromolecules designed with carbon–carbon backbones resisted acceptable mineralization in composting experiments, advocating that unadulterated municipal compost lacks the microbial diversity to enzymatically digest many synthetically derived resins. Additionally, polymers that demonstrated acceptable biodegradability in internal and published OECD aquatic studies, including chitosan and polyvinyl alcohol, exhibited limited respiration in local municipal compost; hence, untested correlations between aquatic, soil, and compost testing outcomes should never be assumed.
Full article
(This article belongs to the Collection Editorial Board Members' Collection Series: "Sustainability in Materials and Processes in Cosmetic Science")
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Open AccessCommunication
Skin Care Function of Lactoferrin Was Characterized Using Recombinant Human Epidermal Model
by
Tong Xie, Wu Qiao, Tinghan Jia and Ken Kaku
Cosmetics 2024, 11(3), 98; https://doi.org/10.3390/cosmetics11030098 - 15 Jun 2024
Abstract
The effect of lactoferrin on skin was simulated using a recombinant human epidermal model. The anti-inflammatory and soothing effect of lactoferrin was verified using IL-1α and TSLP Elisa assay. The effects of lactoferrin on the expression of related genes and proteins were detected
[...] Read more.
The effect of lactoferrin on skin was simulated using a recombinant human epidermal model. The anti-inflammatory and soothing effect of lactoferrin was verified using IL-1α and TSLP Elisa assay. The effects of lactoferrin on the expression of related genes and proteins were detected using qPCR and immunofluorescence staining. The results showed that lactoferrin can effectively enhance the Transepidermal Electrical Resistance (TEER) and inhibit the secretion of inflammatory cytokine IL-1α and TSLP. In addition, it was confirmed using qPCR that lactoferrin had high expression levels on AQP3, FLG, IVL, CLDN1 and HAS1 genes. Immunofluorescence staining confirmed that lactoferrin had high fluorescence intensity and expression in AQP3, Filaggrin and Involucrin. The results showed that lactoferrin improved the skin barrier at higher than 1.5 mg/mL. At the same time, it can have anti-inflammatory and moisturizing effects. This study provides a strong basis for the application of lactoferrin in cosmetics and daily chemical products.
Full article
(This article belongs to the Special Issue In Vitro Skin Models for Skin Function Assessment: Applications in Cosmetics and Dermocosmetics)
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Open AccessArticle
Exploring the In Vitro Antioxidant, Anti-Aging, and Cytotoxic Properties of Kaempferia galanga Linn. Rhizome Extracts for Cosmeceutical Formulations
by
Panikchar Wichayapreechar, Ranit Charoenjittichai, Anchalee Prasansuklab, Maria Pilar Vinardell and Wandee Rungseevijitprapa
Cosmetics 2024, 11(3), 97; https://doi.org/10.3390/cosmetics11030097 - 13 Jun 2024
Abstract
Kaempferia galanga Linn. (KG), a member of the family Zingiberaceae, is native to India, and commonly found in China, Indonesia, and Thailand. It has been used as a food condiment, folk medicine, and to relieve skin diseases due to its biological activities. However,
[...] Read more.
Kaempferia galanga Linn. (KG), a member of the family Zingiberaceae, is native to India, and commonly found in China, Indonesia, and Thailand. It has been used as a food condiment, folk medicine, and to relieve skin diseases due to its biological activities. However, its anti-aging effect has not yet been investigated. In this study, the rhizome of Kaempferia galanga Linn was extracted with solvents of different polarities (deionized water, absolute ethanol, ethyl acetate, and hexane). Phytochemical screening assay, total flavonoid and total phenolic contents, antioxidant activity (DPPH•, FRAP, ABTS +• assay), anti-aging activity (anti-collagenase, anti-elastase), and cell cytotoxicity on human dermal fibroblasts were investigated. The outcomes revealed that the extraction in highly polar solvents resulted in a high extract yield. Flavonoids, phenolic, and terpenoid compounds were detected in KG extracts using all extraction solvents. However, deionized water as a solvent exhibited the lowest level of flavonoids and phenolics, as compared to the other solvents. The highest total flavonoid and phenolic contents were achieved through extraction with absolute ethanol and ethyl acetate, respectively. Interestingly, the extract obtained with absolute ethanol exhibited the most potent antioxidant activities (the IC50 value of DPPH• was 0.612 mg/mL, the FRAP value was 62.79 mmol of Fe2+/g of extract, and TEAC value was 9.21 mg TE/g of extract in ABTS+• assay) and anti-aging properties (the percentages of collagenase inhibitory and elastase were 71.83%, and 66.35%, respectively). Regarding cell cytotoxicity, both KG extracts obtained with deionized water and absolute ethanol showed lower toxicity on human dermal fibroblasts compared to those obtained with ethyl acetate and hexane. Ethanol-based KG extract demonstrated a good antioxidant, anti-aging capacity and is considered safe for cosmeceutical products focused on anti-aging applications.
Full article
(This article belongs to the Special Issue Anti-oxidant and Anti-inflammatory Properties of Natural Compounds - 2nd Edition)
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Open AccessSystematic Review
How Do Artificial Intelligence, Social Media Platforms and Photo Editing Applications Influence Cosmetic Surgery Choices—Literature Systematic Review and Prospective Study
by
Malek Benamor, Stefana Luca, Jed Bouguila, Oxana Madalina Grosu, Bianca Maria Avadani, Dan Cristian Moraru and Mihaela Pertea
Cosmetics 2024, 11(3), 96; https://doi.org/10.3390/cosmetics11030096 - 11 Jun 2024
Abstract
Background: In recent years, social media and AI have indirectly taken control of our daily lives. We bring attention to the impact that social networks, photo-editing applications, and artificial intelligence have on potential patients when they are looking for a surgeon for a
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Background: In recent years, social media and AI have indirectly taken control of our daily lives. We bring attention to the impact that social networks, photo-editing applications, and artificial intelligence have on potential patients when they are looking for a surgeon for a possible cosmetic surgery, as well as the criteria they consider in relation to the interest in the use of the internet by surgeons. Methods: A systematic review of the past 10 years (2014–2024) was conducted following the PRISMA structure. PubMed and Google Scholar were searched for articles containing the following terms: plastic/esthetic surgery, social media, AI, filters, dysmorphia. All articles were saved using Zotero software version 6.0.37. We reported a prospective study including a 141 patients applying for esthetic surgical interventions in the time interval between February and October 2021. It also involved 44 esthetic surgeons from Tunisian clinics. The influence of social media was evaluated using questionnaires made based on the literature. Results: Using the keyword search, 71 articles were found. A total of 19 articles were selected for data extraction. It was observed that in the last 3 years, the literature has focused on photo-editing and AI in the cosmetic surgery field. A total of 107 patients chose their surgeon based on a surgeon’s social medias rather than their reputation and their website. Conclusions: The increased advancements of the internet have clearly influenced decision making in the field of cosmetic surgery.
Full article
(This article belongs to the Special Issue Treatment for Anti-aging and Rejuvenation)
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Open AccessArticle
A Mn (II) Quinoline Complex (4QMn) Mitigates Oxidative Damage Induced by Ultraviolet Radiation and Protein Aggregation
by
Marián Merino, Sonia González, Mª Paz Clares, Enrique García-España and José L. Mullor
Cosmetics 2024, 11(3), 95; https://doi.org/10.3390/cosmetics11030095 - 6 Jun 2024
Abstract
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Solar radiation, specifically ultraviolet radiation (UVR), is one of the harmful external factors that affect the integrity of the skin upon sun overexposure. Its detrimental effects include skin aging (photoaging), pigmentation disorders, and skin cancer. Upon UVR exposure, a cascade of different cellular
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Solar radiation, specifically ultraviolet radiation (UVR), is one of the harmful external factors that affect the integrity of the skin upon sun overexposure. Its detrimental effects include skin aging (photoaging), pigmentation disorders, and skin cancer. Upon UVR exposure, a cascade of different cellular responses is initiated, giving rise to inflammatory processes, oxidative stress, protein misfolding, and DNA lesions, among other effects. Therefore, there is a growing need to explore and characterize new compounds for safeguarding the skin from solar radiation-induced damage. In this work, we analyze the antioxidant and anti-inflammatory capacities of the Mn (II) quinone complex (4QMn) in different cellular models and human skin explants. Importantly, our results suggest that 4QMn is able to ameliorate the oxidative damage produced by protein aggregation by reducing ROS levels, mitochondrial ROS (MitoROS), and DNA oxidative damage (8OH-dG) in a protein accumulation model. These findings suggest that the 4QMn compound could mitigate the deleterious effects of different sources of oxidative damage.
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Open AccessArticle
Chemical Profile and Antioxidant and Tyrosinase Inhibitory Activity of Chamaemelum nobile L. Green Extracts
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Luciana Maria Polcaro, Antonietta Cerulli, Francesco Montella, Elena Ciaglia, Milena Masullo and Sonia Piacente
Cosmetics 2024, 11(3), 94; https://doi.org/10.3390/cosmetics11030094 - 6 Jun 2024
Abstract
The request for skin-whitening agents and bioactive principles able to control hyperpigmentation disorders is continuously growing. Chamomile (Matricaria chamomilla) is used as a remedy for skin diseases, but little is known about the ability of Roman chamomile (Chamaemelum nobile)
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The request for skin-whitening agents and bioactive principles able to control hyperpigmentation disorders is continuously growing. Chamomile (Matricaria chamomilla) is used as a remedy for skin diseases, but little is known about the ability of Roman chamomile (Chamaemelum nobile) to act as a skin-whitening agent. With the aim to investigate antioxidant and lightening potential, fresh aerial parts of C. nobile were extracted by maceration, ultrasound-assisted extraction, and solid–liquid dynamic (SLDE-Naviglio) extraction using EtOH/H2O mixtures. Moreover, 32 metabolites (flavonoids, sesquiterpenoids, amides, and polar fatty acids) were identified by liquid chromatography/mass spectrometry. Principal component analysis revealed how the extract EtOH/H2O 50% (Naviglio and long maceration), along with the extract EtOH/H2O 60% (maceration) were richest in flavonoids. All extracts were tested by TEAC and DPPH assays, and to determine their in vitro antioxidant activity, the DHR 123 probe–intracellular ROS assay in HaCaT cells, for some extracts, was performed. Moreover, their ability to exert a whitening effect was tested by analyzing their tyrosinase inhibitory activity. The quantitative determination of apigenin, known as a natural tyrosinase inhibitor, was performed by LC-ESI/QTrap/MS/MS using the multiple reaction monitoring (MRM) method. These results are promising for selecting an extraction method to obtain a sustainable product rich in bioactives.
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(This article belongs to the Special Issue Current and Future Trends in Cosmetics Research: The 10th Anniversary of Cosmetics)
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Open AccessArticle
Electrospray-Mangiferin Nanoparticles Gel: A Promising Agent for Sun and Age Defense
by
Neungreuthai Chomchoei, Pimporn Leelapornpisid, Pratchaya Tipduangta, Jakkapan Sirithunyalug, Busaban Sirithunyalug and Pawitrabhorn Samutrtai
Cosmetics 2024, 11(3), 93; https://doi.org/10.3390/cosmetics11030093 - 5 Jun 2024
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UV irradiation causes skin damage and aging. This study aimed to develop and evaluate a gel formulation loaded with electrospray mangiferin nanoparticles (MNPs) as a double-action product with photoprotective and anti-aging properties. The MNPs were prepared using the electrospraying technique and loaded in
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UV irradiation causes skin damage and aging. This study aimed to develop and evaluate a gel formulation loaded with electrospray mangiferin nanoparticles (MNPs) as a double-action product with photoprotective and anti-aging properties. The MNPs were prepared using the electrospraying technique and loaded in a gel formulation. The MNP formulation was evaluated regarding its physical appearance, viscosity, in vitro sun protection factor (SPF), and in vitro anti-oxidant activity and compared with a formulation containing purified mangiferin (PM) at the same concentration of 0.2% (w/v). Moreover, both formulations were analyzed for their in vitro release and ex vivo skin permeation. The MNP formulation had a considerably higher SPF value than the PM formulation at the same concentration (20.43 ± 0.13 and 12.19 ± 0.27, respectively). The in vitro anti-oxidant activities of the formulations with MNPs and PM were 74.47 ± 2.19% and 80.52 ± 1.05%, respectively. The MNP formulation showed potent photoprotective and anti-oxidation activities with acceptable stability in all parameters under accelerated conditions (4 ± 2 °C 48 h/45 ± 2 °C 48 h for 6 cycles) and after 30 days of storage under various conditions. The release profile data of the MNPs showed a controlled release pattern at 76.97 ± 0.06% at 480 min. Furthermore, after using a Franz diffusion cell for 8 h, the MNP formulation showed the release of 37.01 ± 2.61% and 22.39 ± 1.59% of mangiferin content in the skin layer as stratum corneum and viable epidermis, respectively. Therefore, the overall results demonstrate that electrospray MNPs in a gel formulation are suitable for skin and constitute a promising delivery system for mangiferin in developing cosmetics and cosmeceutical products with good potential.
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Open AccessArticle
The Comparative Efficacy and Safety of 250 μm versus 350 μm Long Microneedle Patch on Under-Eye Skin
by
Apisama Arepagorn, Jitlada Meephansan, Punyaphat Sirithanabadeekul, Kittipong Tantisantisom, Sattra Thongma, Yossawat Rayanasukha, Thitikorn Boonkoom and Paisan Khanchaitit
Cosmetics 2024, 11(3), 92; https://doi.org/10.3390/cosmetics11030092 - 5 Jun 2024
Abstract
Background: Microneedle patch (MNP) technology is now applied for many purposes, including transdermal drug delivery and percutaneous collagen induction in the cosmetic and dermatology fields. Previous research showed that a MNP effectively improved skin appearance, while treatments using larger or deeper microneedles were
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Background: Microneedle patch (MNP) technology is now applied for many purposes, including transdermal drug delivery and percutaneous collagen induction in the cosmetic and dermatology fields. Previous research showed that a MNP effectively improved skin appearance, while treatments using larger or deeper microneedles were not easily tolerated by human subjects. Few studies have compared MNP designs in humans. Study Objective: To compare novel MNP designs with high length and low density versus low length and high density for rejuvenating skin wrinkles under the eyes. Methods: This non-randomized split-face clinical trial was conducted as a double-blind study with 36 Thai female participants. Each participant was treated with two different MNP designs, one on each side of the face. The microneedle lengths were 250 μm with a density of 945 needles/cm2 on the left side of the face under the eye and 350 μm with a density of 482 needles/cm2 on the right side of the face under the eye. The treatments were applied for 12 weeks, with the assessment outcomes evaluated at the baseline and 2, 4, 6, 8, 10, and 12 weeks. Results: The application of these two novel MNP designs successfully rejuvenated under-eye wrinkles with low pain level scores. Increasing the length of the needle or having a 350 μm long MN can better reduce under-eye wrinkles without statistical significance. During the study period, there was an improvement in skin surface roughness in both groups accompanied by a consistent reduction in under-eye skin wrinkles, without statistically significant differences observed between the groups when using the Antera 3D system. However, the 350 μm long MN also slightly increased the pain compared to the shorter needles (250 μm long MN) with a higher density of needles. There were no side effects associated with the two designs. Conclusions: The two novel MNPs gave favorable results as a safe non-invasive treatment for the rejuvenation of skin wrinkles under the eyes. Increasing the number of needles and increasing the length of the needles were both effective in safely reducing under-eye wrinkles without any adverse effects. Additionally, participants could self-apply them at home and were highly satisfied. However, increasing the length of the needles may result in slightly more pain compared to increasing the number of needles.
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(This article belongs to the Special Issue 10th Anniversary of Cosmetics—Recent Advances and Perspectives)
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Open AccessArticle
Towards the Development of a Cream with Antiviral Properties Targeting Both the Influenza A Virus and SARS-CoV-2
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Philippe Mangeot, Kristell Lazou, Aurelia Blin, Valerie Gorzelanczyk, Olivier Jeanneton, Chantal Kurfurst, Karl Pays, Bruno Bavouzet, Carine Nizard, Theophile Ohlmann and Anne-Laure Bulteau
Cosmetics 2024, 11(3), 91; https://doi.org/10.3390/cosmetics11030091 - 4 Jun 2024
Abstract
Objective: Many severe acute respiratory infections are caused by viral pathogens, and viruses are responsible for a large number of deaths worldwide. Among the most common respiratory viruses are the influenza A virus (IAV) and, more recently, the SARS-CoV-2 that emerged in 2019
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Objective: Many severe acute respiratory infections are caused by viral pathogens, and viruses are responsible for a large number of deaths worldwide. Among the most common respiratory viruses are the influenza A virus (IAV) and, more recently, the SARS-CoV-2 that emerged in 2019 and caused the most significant human pandemic of the beginning of the 21st century. Both IAV and SARS-CoV-2 share clinical features and a common transmission route through the emission of viral particles via aerosols and droplets. These penetrate the host after entry from the nose and mouth or an indirect mode of transmission via contact contamination of different media. These facts prompted us to investigate the possibility of designing a soft cream with a virucidal activity targeted against IAV and SARS-CoV-2. Methods: We first investigated the action of chemical compounds known to have antiviral properties such as cyclodextrin, or algae extracts containing sulfated polysaccharides, on cultured cells infected with lentiviral viral particles pseudotyped (VP) with either proteins HA (hemagglutinin) and NA (neuraminidase) from IAV or the G protein from the vesicular stomatitis virus or spike-bearing particles in order to select molecules with antiviral activities in human embryonic kidney (HEK293T) cells. Results: Our results show that some cyclodextrin-containing creams can significantly reduce the stability of HANA- and spike-bearing particles when they are applied prior to challenge with a viral inoculum on skin. Conclusions: We observed some specificities of these creams towards either IAV or SARS-CoV-2, indicating that the neutralization of viral activity is correlated with the mechanism of receptor interaction and entry of these two pathogens.
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(This article belongs to the Special Issue Current and Future Trends in Cosmetics Research: The 10th Anniversary of Cosmetics)
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Open AccessReview
Disturbances in the Skin Homeostasis: Wound Healing, an Undefined Process
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Montserrat Férnandez-Guarino, Jorge Naharro-Rodriguez and Stefano Bacci
Cosmetics 2024, 11(3), 90; https://doi.org/10.3390/cosmetics11030090 - 4 Jun 2024
Abstract
This review was written with the aim of examining the effects that cause an insult, such as a wound, to an organ, such as the skin. Before examining the cellular mechanisms relating to wound healing, the reader is invited to read about the
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This review was written with the aim of examining the effects that cause an insult, such as a wound, to an organ, such as the skin. Before examining the cellular mechanisms relating to wound healing, the reader is invited to read about the structure of the skin as a necessary basis for understanding the final aim of this review. The structure of the skin as a basis for understanding the phenomena relating to wound healing is addressed, taking into account the updated literature that addresses the numerous problems of the skin microenvironment. Starting from this awareness, the paragraphs dedicated to wound healing become complicated when this phenomenon is not implemented and therefore while the problems of chronic wounds, keloids, and hypertrophic scars are addressed, these are pathologies that are still difficult to understand and treat today.
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(This article belongs to the Special Issue 10th Anniversary of Cosmetics—Recent Advances and Perspectives)
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10th Anniversary of Cosmetics—Recent Advances and Perspectives
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Bioactive Compounds From Natural Resources Against Skin Aging
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Active Substances and Bioavailability in Cosmetics
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