Full Face Tailored Treatments Using Hyaluronan Dermal Fillers: Biophysical Characterization for Safe and Effective Approaches
Abstract
:1. Introduction
2. Methods
3. HA Dermal Filler In Vitro Characterization
3.1. Cross-Linking Reaction and Rheological Characteristics of HA Dermal Fillers
3.1.1. BDDE Cross-Linking
3.1.2. Rheology
3.2. Mechanical and Hydrating Ability of HA Dermal Fillers
4. HA Dermal Fillers’ Clinical Application
4.1. Clinical Studies and Regulatory Framework
4.1.1. Regulatory Requirements
4.1.2. Clinical Trials
4.1.3. Tissue Integration and Safety
4.2. HA Dermal Filler Treatments and Clinical Experiences
4.2.1. Volumizing Treatments Using Aliaxin® Dermal Fillers
4.2.2. Contouring Treatments with “Soft” Aliaxin® Dermal Fillers
4.2.3. Treating the Lips Using Aliaxin® Dermal Fillers
5. Conclusions and Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Aliaxin® Hydrogel | Total HA (mg/mL) | MW (kDa) | G′ (Pa) | Tan δ | Cohesivity | Cross-Linking Score | |
---|---|---|---|---|---|---|---|
AEV | 25 | 1000, 2000 | 162 | 0.15 | 5 | 5/5 | [4,11,13] |
AFL | 25 | 500, 1000 | 45 | 0.40 | 5 | 3/5 | [4,16,19] |
AGP | 25 | 1000, 2000 | 95 | 0.23 | 5 | 4/5 | [4,12,19] |
ALV | 25 | 1000, 2000 | 107 | 0.21 | 5 | 4/5 | [17,22] |
ASR | 25 | 500, 1000, 2000 | 39 | 0.51 | 5 | 2/5 | [4,14,19] |
ASV | 25 | 2300 | 295 | 0.12 | 4 | 5/5 | [11,15,19] |
Aliaxin® Hydrogel | Clinical Outcome | References |
---|---|---|
AEV | Volumizing treatment for the mid-face (cheeks and cheekbones), nasolabial folds, and chin | [4,19,45] |
AFL | Hydrating treatment for the lips and marionette lines | [4,19,55,56] |
AGP | Hydrating and soft shaping treatment for nasolabial folds and superficial wrinkles, including the mouth, forehead, and glabellar wrinkles | [4,19,57,58,59] |
ALV | Volumizing treatment for lips | [46,55,60] |
ASR | Hydrating and soft shaping treatment for nasolabial folds and superficial wrinkles, including the mouth, forehead, and glabellar wrinkles | [4,19,61] |
ASV | Volumizing treatment for the mid-face (cheeks and cheekbones), facial contours, very deep wrinkles, nasal imperfections | [23,44,57] |
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Molina, B.; Romano, D.; Zazzaron, M.; Kramer, E.; Cigni, C.; Grimolizzi, F.; Bellia, G. Full Face Tailored Treatments Using Hyaluronan Dermal Fillers: Biophysical Characterization for Safe and Effective Approaches. Cosmetics 2024, 11, 144. https://doi.org/10.3390/cosmetics11040144
Molina B, Romano D, Zazzaron M, Kramer E, Cigni C, Grimolizzi F, Bellia G. Full Face Tailored Treatments Using Hyaluronan Dermal Fillers: Biophysical Characterization for Safe and Effective Approaches. Cosmetics. 2024; 11(4):144. https://doi.org/10.3390/cosmetics11040144
Chicago/Turabian StyleMolina, Beatriz, Domenico Romano, Michela Zazzaron, Eyal Kramer, Clara Cigni, Franco Grimolizzi, and Gilberto Bellia. 2024. "Full Face Tailored Treatments Using Hyaluronan Dermal Fillers: Biophysical Characterization for Safe and Effective Approaches" Cosmetics 11, no. 4: 144. https://doi.org/10.3390/cosmetics11040144