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Cosmetics
Volume 12
Issue 2
10.3390/cosmetics12020034
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Skin Antiaging and Skin Health Benefits of Probiotic Intake Combined with Topical Ectoin and Sodium Hyaluronate: A Randomized, Double-Blind, Placebo-Controlled Trial

by
Vincenzo Nobile
1,*,
Cother Hajat
2,
Enza Cestone
3,
Federica Cascella
1,4 and
Giacomo Santus
5
1
R&D Department, Complife Italia S.r.l., 27028 San Martino Siccomario, PV, Italy
2
Real World Health, London SW1 98EF, UK
3
Clinical Trial Department, Complife Italia, 27028 San Martino Siccomario, PV, Italy
4
Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, NO, Italy
5
ROELMI Holding, 20020 Solaro, MI, Italy
*
Author to whom correspondence should be addressed.
Cosmetics 2025, 12(2), 34; https://doi.org/10.3390/cosmetics12020034 (registering DOI)
Submission received: 3 January 2025 / Revised: 18 February 2025 / Accepted: 20 February 2025 / Published: 22 February 2025
Versions Notes

Abstract

Well-aging strategies include the use of both oral and topic products to nourish the skin from the inside out. A clinical–instrumental study was conducted on 96 Caucasian subjects with mild-to-moderate facial aging to demonstrate the efficacy of probiotic (Lactobacillus plantarum PBS067, Lactobacillus reuteri PBS072, and Lactobacillus rhamnosus LRH020) intake combined with topical ectoin and sodium hyaluronate. The skin sebum content, hydration and moisturization, profilometry (wrinkle depth and skin smoothness), TEWL, elasticity (R0 and R2 parameters), radiance, and pores (size and impurities) were measured after 4 and 8 weeks of product use. These parameters were also integrated through a self-assessment questionnaire to align the measured and the perceived efficacy. One hour after serum application, the wrinkle depth was reduced by 9.2%, while skin hydration increased by 16.6% and skin radiance by 19.1% following cream application. After 4 and 8 weeks of use, both the oral and topical products were shown to respect the skin’s hydrolipid film, effectively improve skin parameters associated with aging, and detoxify the skin from impurities. The mechanism behind these improvements was linked to an enhancement of the skin microbiome. Our findings clearly demonstrate the efficacy of probiotic intake combined with topical ectoin and sodium hyaluronate in enhancing skin health and mitigating the signs of skin aging.
Keywords: skin aging; probiotics; ectoin; sodium hyaluronate; clinical trial skin aging; probiotics; ectoin; sodium hyaluronate; clinical trial

Share and Cite

MDPI and ACS Style

Nobile, V.; Hajat, C.; Cestone, E.; Cascella, F.; Santus, G. Skin Antiaging and Skin Health Benefits of Probiotic Intake Combined with Topical Ectoin and Sodium Hyaluronate: A Randomized, Double-Blind, Placebo-Controlled Trial. Cosmetics 2025, 12, 34. https://doi.org/10.3390/cosmetics12020034

AMA Style

Nobile V, Hajat C, Cestone E, Cascella F, Santus G. Skin Antiaging and Skin Health Benefits of Probiotic Intake Combined with Topical Ectoin and Sodium Hyaluronate: A Randomized, Double-Blind, Placebo-Controlled Trial. Cosmetics. 2025; 12(2):34. https://doi.org/10.3390/cosmetics12020034

Chicago/Turabian Style

Nobile, Vincenzo, Cother Hajat, Enza Cestone, Federica Cascella, and Giacomo Santus. 2025. "Skin Antiaging and Skin Health Benefits of Probiotic Intake Combined with Topical Ectoin and Sodium Hyaluronate: A Randomized, Double-Blind, Placebo-Controlled Trial" Cosmetics 12, no. 2: 34. https://doi.org/10.3390/cosmetics12020034

APA Style

Nobile, V., Hajat, C., Cestone, E., Cascella, F., & Santus, G. (2025). Skin Antiaging and Skin Health Benefits of Probiotic Intake Combined with Topical Ectoin and Sodium Hyaluronate: A Randomized, Double-Blind, Placebo-Controlled Trial. Cosmetics, 12(2), 34. https://doi.org/10.3390/cosmetics12020034

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