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Volume 7
Issue 2
10.3390/cosmetics7020037
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Letter

Anti-Wrinkle Efficacy of Neuropeptide Substance P-Based Hydrogel in Human Volunteers

by
Da Jung Kim
*,
Seul Bi Lee
,
Song Sun Chang
and
Jungsun Lee
Research and Development Institute, Biosolution, Seoul Technopark, 232 Gongneung-ro, Nowon-gu, Seoul 01811, Korea
*
Author to whom correspondence should be addressed.
Cosmetics 2020, 7(2), 37; https://doi.org/10.3390/cosmetics7020037
Submission received: 2 April 2020 / Revised: 19 May 2020 / Accepted: 20 May 2020 / Published: 21 May 2020
(This article belongs to the Special Issue Novel Synthetic Compounds and Natural Products for Pharmaceutical, Personal Care and Cosmetic: Analytical aspects, Structure Elucidation, Bioactivities and Formulation)
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Abstract

This letter is intended to clarify the clinical effectiveness of neuropeptide substance P (SP) in reducing age-related skin wrinkling. This is the first clinical study to evaluate the efficacy of the topical application of SP on wrinkle reduction. For the clinical study, we tested the efficacy of a stable SP formulation known as SP-based hydrogel against skin aging in study participants. We found that this SP-based hydrogel reduced skin aging based on changes observed in several cutaneous parameters.
Keywords: substance P; hydrogel; anti-wrinkle efficacy; clinical study; cosmeceutical substance P; hydrogel; anti-wrinkle efficacy; clinical study; cosmeceutical

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MDPI and ACS Style

Kim, D.J.; Lee, S.B.; Chang, S.S.; Lee, J. Anti-Wrinkle Efficacy of Neuropeptide Substance P-Based Hydrogel in Human Volunteers. Cosmetics 2020, 7, 37. https://doi.org/10.3390/cosmetics7020037

AMA Style

Kim DJ, Lee SB, Chang SS, Lee J. Anti-Wrinkle Efficacy of Neuropeptide Substance P-Based Hydrogel in Human Volunteers. Cosmetics. 2020; 7(2):37. https://doi.org/10.3390/cosmetics7020037

Chicago/Turabian Style

Kim, Da Jung, Seul Bi Lee, Song Sun Chang, and Jungsun Lee. 2020. "Anti-Wrinkle Efficacy of Neuropeptide Substance P-Based Hydrogel in Human Volunteers" Cosmetics 7, no. 2: 37. https://doi.org/10.3390/cosmetics7020037

APA Style

Kim, D. J., Lee, S. B., Chang, S. S., & Lee, J. (2020). Anti-Wrinkle Efficacy of Neuropeptide Substance P-Based Hydrogel in Human Volunteers. Cosmetics, 7(2), 37. https://doi.org/10.3390/cosmetics7020037

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