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Diseases, Volume 10, Issue 2

2022 June - 17 articles

Cover Story: In the occupational setting, workers can be exposed to high levels of allostatic load (chronic stress) and perfluoroalkyl and polyfluoroalkyl substances (PFAS). The interaction of these factors in the occupational setting is unknown. The results of our study show that AL has a strong association with the interaction of some PFAS with different association measures existing across varying occupations. Our study also demonstrates that increased AL is positively associated with different occupation groups and with certain PFAS concentrations. Finally, AL has a strong association with the interaction of some PFAS and occupation with different association measures existing across varying occupations. In summary, interventions are needed to limit exposure to stressors and PFAS in the work environment to promote longevity among the workforce in the US. View this paper
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Articles (17)

  • Article
  • Open Access
3 Citations
3,572 Views
14 Pages

Metals and Metallothionein Expression in Relation to Progression of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka

  • S. H. Nandana P. Gunawickrama,
  • A. Rajith N. Silva,
  • P. G. Chandra L. Nanayakkara,
  • K. B. Suneetha Gunawickrama,
  • J. M. Kithsiri B. Jayasekara and
  • Naduviladath V. Chandrasekharan

Chronic kidney disease of unknown etiology was investigated for metal relations in an endemic area by a cross-sectional study with CKD stages G1, G2, G3a, G3b, G4, G5 (ESRD), and endemic and nonendemic controls (EC and NEC) as groups. Subjects with t...

  • Review
  • Open Access
14 Citations
6,107 Views
21 Pages

Bone marrow, besides the known functions of hematopoiesis, is an active organ of the immune system, functioning as a sanctuary for several mature immune cells. Moreover, evidence suggests that hematopoietic stem cells (the bone marrow’s functio...

  • Article
  • Open Access
4 Citations
3,107 Views
18 Pages

Ensemble Models for Tick Vectors: Standard Surveys Compared with Convenience Samples

  • William H. Kessler,
  • Carrie De Jesus,
  • Samantha M. Wisely and
  • Gregory E. Glass

Ensembles of Species Distribution Models (SDMs) represent the geographic ranges of pathogen vectors by combining alternative analytical approaches and merging information on vector occurrences with more extensive environmental data. Biased collection...

  • Article
  • Open Access
1 Citations
3,672 Views
9 Pages

Neck Circumference as a Screening Tool for Metabolic Syndrome among Lebanese College Students

  • Suzan A. Haidar,
  • Nanne de Vries,
  • Kalliopi-Anna Poulia,
  • Hussein Hassan,
  • Mohammad Rached and
  • Mirey Karavetian

Metabolic syndrome (MetS) is a cluster of symptoms that, when present, increase the risk for cardiovascular disease. There is a need for reliable screening tools that are ethnically sensitive. Two hundred and sixty-six college students were assessed...

  • Review
  • Open Access
24 Citations
4,128 Views
14 Pages

Secondary Mechanisms of Neurotrauma: A Closer Look at the Evidence

  • Sina Aghili-Mehrizi,
  • Eric Williams,
  • Sandra Yan,
  • Matthew Willman,
  • Jonathan Willman and
  • Brandon Lucke-Wold

Traumatic central nervous system injury is a leading cause of neurological injury worldwide. While initial neuroresuscitative efforts are focused on ameliorating the effects of primary injury through patient stabilization, secondary injury in neurotr...

  • Technical Note
  • Open Access
2 Citations
3,076 Views
12 Pages

When a Multidisciplinary Approach Is Life-Saving: A Case Report of Cardiogenic Shock Induced by a Large Pheochromocytoma

  • Raffaele Baio,
  • Tommaso Pagano,
  • Giovanni Molisso,
  • Umberto Di Mauro,
  • Olivier Intilla,
  • Francesco Albano,
  • Fulvio Scarpato,
  • Stefania Giacometti and
  • Roberto Sanseverino

Background: Pheochromocytoma is known for its instantaneous presentation, especially in the younger population. Hemodynamic instability may be the cause of severe complications and impede patients’ ability to undergo surgical treatment. These t...

  • Review
  • Open Access
17 Citations
7,570 Views
35 Pages

Natural Bioactive Products and Alzheimer’s Disease Pathology: Lessons from Caenorhabditis elegans Transgenic Models

  • María D. Navarro-Hortal,
  • Jose M. Romero-Márquez,
  • Safa Osta,
  • Victoria Jiménez-Trigo,
  • Pedro Muñoz-Ollero and
  • Alfonso Varela-López

Alzheimer’s disease (AD) is an age-dependent, progressive disorder affecting millions of people. Currently, the therapeutics for AD only treat the symptoms. Although they have been used to discover new products of interest for this disease, mam...

  • Review
  • Open Access
7 Citations
4,803 Views
9 Pages

The Role of Inflammation in Anal Cancer

  • Amir Selimagic,
  • Ada Dozic,
  • Azra Husic-Selimovic,
  • Nijaz Tucakovic,
  • Amir Cehajic,
  • Anela Subo,
  • Azra Spahic and
  • Nedim Vanis

The aim of this article was to present a summary of the current resources available in the literature regarding the role of inflammation in anal cancer development. Anal cancer is relatively uncommon, accounting for about 2.7% of all reported gastroi...

  • Article
  • Open Access
6 Citations
3,835 Views
12 Pages

29 April 2022

Objective: This study sought to assess the associations between occupation, serum concentrations of selected of Per- and Polyfluoroalkyl Substances (PFAS), and chronic physiological stress, as operationalized by Allostatic Load (AL), among adults age...

  • Article
  • Open Access
5 Citations
3,805 Views
9 Pages

Evaluation of Natural and Vaccine-Induced Anti-SARS-CoV-2 Immunity: A Comparative Study between Different Groups of Volunteers

  • Maria Caterina Schipani,
  • Flaminia Tomassetti,
  • Isabella Polidori,
  • Paola Ricci,
  • Maria Loredana Frassanito,
  • Silva Seraceni,
  • Maria Morello,
  • Eleonora Nicolai,
  • Stefano Aquaro and
  • Graziella Calugi
  • + 2 authors

27 April 2022

(1) Background: The production of anti-SARS-CoV-2 antibodies should help minimize the severity of COVID-19 disease. Our focus was to investigate and compare different vaccination schedules, monitoring circulating S-RBD Ab (antibodies anti—Spike...

  • Brief Report
  • Open Access
3,134 Views
6 Pages

24 April 2022

Checkpoint inhibitor (CPI) therapy has only recently been introduced in the first-line treatment of advanced gastric cancer. However, later line monotherapy CPI efficacy in a subset of patients was presented about four years prior. Here, we present t...

  • Review
  • Open Access
3 Citations
3,558 Views
11 Pages

Therapeutic Advances and Challenges in the Management of HER2-Positive Gastroesophageal Cancers

  • Jeremy Chuang,
  • Samuel Klempner,
  • Kevin Waters,
  • Katelyn Atkins,
  • Joseph Chao,
  • May Cho,
  • Andrew Hendifar,
  • Alexandra Gangi,
  • Miguel Burch and
  • Jun Gong
  • + 1 author

19 April 2022

Gastroesophageal cancer is one of the most common cancers in the world, with a high rate of mortality. While there has been significant progress over the past decade, particularly with the addition of anti-HER2 therapies to platinum-based chemotherap...

  • Article
  • Open Access
7 Citations
4,555 Views
11 Pages

Mean Platelet Volume as a Predictor of COVID-19 Severity: A Prospective Cohort Study in the Highlands of Peru

  • Jhosef Franck Quispe-Pari,
  • Jose Armando Gonzales-Zamora,
  • Judith Munive-Dionisio,
  • Cristhian Castro-Contreras,
  • Abelardo Villar-Astete,
  • Cesar Kong-Paravicino,
  • Pierina Vilcapoma-Balbin and
  • Jorge Hurtado-Alegre

15 April 2022

Introduction: Although 80% of symptomatic individuals with COVID-19 develop mild forms, it is the severe (15%) and critical (5%) forms that have the greatest impact in the hospital setting. Recognizing markers that can predict severe forms is essenti...

  • Case Report
  • Open Access
2 Citations
3,215 Views
6 Pages

Metastatic Anorectal Melanoma Presenting as Seizures: An Infrequent Culprit

  • Joao Galante,
  • Sola Adeleke,
  • Rosemeen Parkar,
  • Nipin Bagla,
  • Albert Edwards,
  • Stergios Boussios and
  • Rakesh Raman

Anorectal malignant melanoma is a rare culprit of malignancies in the anorectal region. With a presentation that mimics the vastly more common colorectal tumours, clinical misdiagnosis and diagnostic delays often occur, contributing to a dismal progn...

  • Review
  • Open Access
27 Citations
24,183 Views
17 Pages

Hyperkalemia in Diabetes Mellitus Setting

  • Kleber Goia-Nishide,
  • Lucas Coregliano-Ring and
  • Érika Bevilaqua Rangel

28 March 2022

Diabetes mellitus is a global health problem that affects 9.3% of the worldwide population and is associated with a series of comorbidities such as heart failure (HF) and chronic kidney disease (CKD). Diabetic patients, especially those with associat...

  • Article
  • Open Access
9 Citations
4,806 Views
13 Pages

Helicobacter pylori in Native Americans in Northern Arizona

  • Fernando P. Monroy,
  • Heidi E. Brown,
  • Priscilla R. Sanderson,
  • Gregory Jarrin,
  • Mimi Mbegbu,
  • Shari Kyman and
  • Robin B. Harris

23 March 2022

Background: In Arizona Helicobacter pylori prevalence of infection among Navajo adults is about 62% and gastric cancer incidence rate is 3–4 times higher than that of the non-Hispanic White population. Aim: The aim of this study was to estimate...

  • Editorial
  • Open Access
2,653 Views
3 Pages

22 March 2022

When you are part of a community, especially a scientific one, you are required to contribute significantly to its welfare, because the community as a whole represents each individual within it and, in turn, determines the wellbeing of the participan...

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Diseases - ISSN 2079-9721