Metastatic Anorectal Melanoma Presenting as Seizures: An Infrequent Culprit

Round 1

Reviewer 1 Report

Author Response

Reviewer 1

Comments and Suggestions for Authors

Congratulations on presenting this case. This is an unusual case but I don't think it needs any clarification in handling or presentation.

Response:

Thank you for your kind wishes and feedback.

Reviewer 2 Report

This clinical case report from Dr. Galante  and colleagues titled “Metastatic Anorectal Melanoma Presenting as Seizures: An In-2 frequent Culprit” is timely and interesting. It serves the two aims of evidencing an often misrecognized cancer disease and sensitizes the readers to the  therapeutic challenge such a complex metastatic disease poses. Text is clear, description appropriate and references are appropriate.  Figures are clear, figure 4 could be improved (see below).

Minor. Figure 4 could be improved by at least removing the blue background, in order to better visualize the cyto-architecture and the Melanin A pos cells.

Author Response

Reviewer 2

Comments and Suggestions for Authors

This clinical case report from Dr. Galante and colleagues titled “Metastatic Anorectal Melanoma Presenting as Seizures: An In-2 frequent Culprit” is timely and interesting. It serves the two aims of evidencing an often misrecognized cancer disease and sensitizes the readers to the therapeutic challenge such a complex metastatic disease poses. Text is clear, description appropriate and references are appropriate. Figures are clear, figure 4 could be improved (see below).

Minor. Figure 4 could be improved by at least removing the blue background, in order to better visualize the cyto-architecture and the Melanin A pos cells.

Response:

Thanks for the kind comments.

We have now edited background as suggested. We hope this is ok.